Results 271 to 280 of about 1,297,479 (340)

Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations. [PDF]

Schizophrenia (Heidelb)
Perkins DO, Jeffries CD, Clark SR, Upthegrove R, Wannan CMJ, Wray NR, Li QS, Do KQ, Walker E, Paul Amminger G, Anticevic A, Cotter D, Ellman LM, Mongan D, Phassouliotis C, Barbee J, Roth S, Billah T, Corcoran C, Calkins ME, Cerrato F, Khadimallah I, Klauser P, Winter-van Rossum I, Nunez AR, Bleggi RS, Martin AR, Bouix S, Pasternak O, Shah JL, Toben C, Wolf DH, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Kahn RS, Kane JM, McGorry PD, Bearden CE, Nelson B, Shenton ME, Woods SW.   +39 more
europepmc   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Analysis of preoperative serum cytokine levels in patients with oral squamous cell carcinoma. [PDF]

Sci Rep
Bao Z, Yi B.
europepmc   +1 more source

Influence of activating stimulus on functional phenotype: interleukin 2 mRNA accumulation differentially induced by ionophore and receptor ligands in subsets of murine T cells.

, 1988
Kathleen L. McGuire, Jennifer Yang, Ellen V. Rothenberg   +2 more
openalex   +1 more source

Erythropoietin‐Stimulated Macrophage‐Derived Extracellular Vesicles in Chitosan Hydrogel Rescue BMSCs Fate by Targeting EGFR to Alleviate Inflammatory Bone Loss in Periodontitis

Advanced Science, EarlyView.
A therapeutic strategy is proposed for periodontitis using extracellular vesicles derived from EPO‐stimulated macrophages (EPO‐EVs). This schema demonstrates how EPO‐EVs enhance the osteogenic activity of mBMSCs in an inflammatory environment by inhibiting EGFR.
Shuchen Liu, Zhuoran Wang, Yuhuan Li, Ziyi Pan, Lei Huang, Jing Cui, Xue Zhang, Mingxi Yang, Yuan Zhang, Daowei Li, Hongchen Sun   +10 more
wiley   +1 more source

Evaluation of Plasma Biomarkers to Understand the Biology and Heterogeneity of Treatment Effect in Lower Tidal Volume Ventilation Facilitated by Extracorporeal CO2 Removal in Acute Hypoxemic Respiratory Failure: A Secondary Analysis of the REST Trial. [PDF]

Crit Care Explor
Boyle AJ, Reddy K, Conlon J, Auzinger G, Bannard-Smith J, Barrett NA, Camporota L, Gillies MA, Jackson C, McDowell C, Patel B, Perkins GD, Szakmány T, Tunnicliffe W, Welters ID, McNamee JJ, McAuley DF, O'Kane CM.   +17 more
europepmc   +1 more source

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities. [PDF]

J Immunother Cancer
Mullins-Dansereau V, Myre ML, Bardoul A, Geoffroy K, Rallo Pita MJ, Béland D, Desaulniers KL, Roy DG, Bourgeois-Daigneault MC.   +8 more
europepmc   +1 more source

An Intelligent and Conductive Hydrogel with Multiresponsive and ROS Scavenging Properties for Infection Prevention and Anti‐Inflammatory Treatment Assisted by Electrical Stimulation for Diabetic Wound

Advanced Science, EarlyView.
This study introduces a novel therapeutic approach that employs a conductive hydrogel (HEPP) responsive to near‐infrared light, pH levels, and reactive oxygen species. Its goal is to enhance the healing environment affected by elevated glucose levels, insufficient oxygen, and bacterial infections in diabetes‐related wounds.
Tao Zhang, Zongwu Meng, Haoyu Yu, Ping Ding, Tianhan Kai   +4 more
wiley   +1 more source

The effect of eight different gene polymorphisms on osteopenia and osteoporosis in the Turkish population. [PDF]

Rev Assoc Med Bras (1992)
Uzun N, Kiziltunc A, Keskin A.
europepmc   +1 more source