Results 291 to 300 of about 1,297,479 (340)

Engeletin Inhibits Inflammation and Ferroptosis and Attenuates Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation. [PDF]

Acta Cardiol Sin
Yao Y, Ling J, Wang X.
europepmc   +1 more source

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

Advanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang, Chang Shu, Chengwei Xu, Xingjie Zan, Shaoyin Wei, Chenglong Wang, Lianxin Li   +6 more
wiley   +1 more source

Progress in the clinical application of heliox. [PDF]

Med Gas Res
Ke H.
europepmc   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

The influence of dietary choices: investigation of the relationship dietary inflammatory index and fetal growth restriction. [PDF]

BMC Pregnancy Childbirth
Baştemur AG, Gezer İS, Kesikli B, Tanaçan A, Kara Ö, Yazıhan N, Şahin D.   +6 more
europepmc   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

Advanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee, Loi Nguyen Dang, Jinsol Choi, Haesoo Kim, Lyndon Bastatas, Soyeun Park   +5 more
wiley   +1 more source

Diagnostic utility of Th2 cytokines (IL-4, IL-5, IL-10, and IL-13) in pulpal blood for assessing pulpitis severity. [PDF]

BMC Oral Health
Li Q.
europepmc   +1 more source

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Salivary Interleukin-6 and Interleukin-18 Levels and Their Association with Dental Health in Children with Idiopathic Nephrotic Syndrome. [PDF]

Int J Mol Sci
Piekoszewska-Ziętek P, Korytowska-Przybylska N, Pańczyk-Tomaszewska M, Olczak-Kowalczyk D.   +3 more
europepmc   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source