Results 241 to 250 of about 1,132,369 (355)

Intra-articular Delivery of Recombinant Interleukin-1 Receptor Antagonist Protein (Anakinra) Enhances Graft Function in a Porcine Model of Osteochondral Repair. [PDF]

Am J Sports Med
Stoeckl BD, Flaugh RA, Syed AN, Masada KM, Bernstein ER, Lemmon EA, Jenk AC, Laforest LG, Fogarty NL, Dehghani B, Scanzello CR, Carey JL, Steinberg DR, Mauck RL.   +13 more
europepmc   +1 more source

Analysis of candidate genes of spontaneous arthritis in mice deficient for interleukin-1 receptor antagonist

, 2012
Yanhong Cao, Caijuan Li, Jian Yan, Feng Jiao, Xiaoyun Liu, Karen A. Hasty, John Stuart, Weikuan Gu, Yan Jiao   +8 more
openalex   +2 more sources

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

The role of selected cytokines from the interleukin 1 family in the pathophysiology of morphea. [PDF]

Arch Dermatol Res
Cieplewicz-Guźla P, Kowalczyk MJ, Dańczak-Pazdrowska A, Żaba R, Wegner J, Polańska A.   +5 more
europepmc   +1 more source

The influence of human immunodeficiency virus 1 (HIV-1) in interleukin 24 (IL-24) expression from peripheral blood mononuclear cells

, 2012
Scheilla Teixeira [UNIFESP] Strumillo
openalex   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage. [PDF]

Dis Model Mech
Barrington J, Rivers-Auty J, Strangward P, Tamburrano S, Lénárt N, Swanton T, Lemarchand E, Parry-Jones AR, Dénes Á, Brough D, Allan SM.   +10 more
europepmc   +1 more source

A Novel Polymorphism in the Promoter Region of the Interleukin-4 Gene and Association with Type 1 Diabetes Mellitus

, 2003
智子 大久保, Tomoko Ohkubo
openalex   +1 more source

Interleukin-1 receptor-like proteins synthesized by translation, in vitro, of immunopurified polysomal messenger RNA.

, 1988
Vivek M. Rangnekar, Janet M.D. Plate
openalex   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source