Results 301 to 310 of about 1,016,945 (361)

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

Macrophages overexpressing interleukin-10 target and prevent atherosclerosis: Regression of plaque formation and reduction in necrotic core. [PDF]

Bioeng Transl Med
Wang M, Zhou S, Hu Y, Tong W, Zhou H, Ma M, Cai X, Zhang Z, Zhang L, Chen Y.   +9 more
europepmc   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation. [PDF]

Life Metab
Ryan TAJ, Zanoni I.
europepmc   +1 more source

Interleukin-10 gives exhausted chimeric antigen receptor (CAR) T cells a second breath. [PDF]

Cancer Commun (Lond)
Heuser-Loy C.
europepmc   +1 more source

Evaluation of PD-1 and interleukin-10-receptor expression by T lymphocytes in malignant and benign pleural effusions. [PDF]

Clin Exp Med
Mosleh B, Hammer B, El-Gazzar A, Kramer M, Ayazseven S, Bernitzky D, Geleff S, Idzko M, Gompelmann D, Hoda MA.   +9 more
europepmc   +1 more source

Protective effect of recombinant interleukin-10 on newborn rat lungs exposed to short-term sublethal hyperoxia. [PDF]

Clin Exp Pediatr
Lee HS, Ryu YJ, Lee MJ.
europepmc   +1 more source

Novel Impact of Colchicine on Interleukin-10 Expression in Acute Myocardial Infarction: An Integrative Approach. [PDF]

J Clin Med
Handari SD, Rohman MS, Sargowo D, Aulanni'am, Nugraha RA, Lestari B, Oceandy D.   +6 more
europepmc   +1 more source

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Interleukin-10 and the Interleukin-10 Receptor

Annual Review of Immunology, 2001
Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses.
Kevin W. Moore, Anne O'Garra, R L Coffman, de Waal Malefyt R   +3 more
openaire   +3 more sources