Results 311 to 320 of about 1,016,945 (361)
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Annual Review of Immunology, 1993
In the three years since its discovery, the pleiotropic cytokine interleukin-10 (IL-10) has been implicated as an important regulator of the functions of lymphoid and myeloid cells. IL-10's ability to block activation of cytokine synthesis and several accessory cell functions of macrophage renders this cytokine a potent suppressor of the effector ...
K W, Moore +4 more
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In the three years since its discovery, the pleiotropic cytokine interleukin-10 (IL-10) has been implicated as an important regulator of the functions of lymphoid and myeloid cells. IL-10's ability to block activation of cytokine synthesis and several accessory cell functions of macrophage renders this cytokine a potent suppressor of the effector ...
K W, Moore +4 more
openaire +2 more sources
Current Opinion in Immunology, 1992
Despite the short history of interleukin-10, accumulated evidence indicates that this interleukin plays a major role in suppressing immune and inflammatory responses. Yet interleukin-10 also maintains cell viability and acts as a cofactor to promote the growth of lymphoid and myeloid cells in vitro. Here we review the present knowledge on the structure
R, de Waal Malefyt +4 more
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Despite the short history of interleukin-10, accumulated evidence indicates that this interleukin plays a major role in suppressing immune and inflammatory responses. Yet interleukin-10 also maintains cell viability and acts as a cofactor to promote the growth of lymphoid and myeloid cells in vitro. Here we review the present knowledge on the structure
R, de Waal Malefyt +4 more
openaire +2 more sources
Progress in Growth Factor Research, 1992
Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the ...
Dan Berg, Gina Holland, Donna M. Rennick
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Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the ...
Dan Berg, Gina Holland, Donna M. Rennick
openaire +5 more sources
Interleukin-10 and Interleukin-10–Receptor Defects in Inflammatory Bowel Disease
Current Allergy and Asthma Reports, 2012Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other primary immunodeficiencies, IL-10 and IL-10 receptor (
Shah, Neil +3 more
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Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus
Clinical Rheumatology, 2013Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by excessive production of a variety of autoantibodies, accumulation of immune complexes, and multiple organ systems involvement. Interleukin-10 (IL-10) has an important role in the growth, survival, differentiation, and function of B cells.
Dong-Qing Ye +5 more
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Biological properties of interleukin 10
Journal of Clinical Immunology, 1992Interleukin 10 (IL-10) was discovered in 1989 by Mosmann and colleagues as an activity produced by murine type 2 helper T cells which suppressed cytokine production by type 1 helper T cells (1). This activity, initially designated cytokine synthesis inhibitor factor (CSIF), was isolated by expression cloning by Moore and colleagues (2), who ...
M Howard +4 more
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The interleukin-10 family of cytokines
Trends in Immunology, 2002A family of interleukin-10 (IL-10)-related cytokines has emerged, comprising a series of herpesviral and poxviral members and several cellular sequence paralogs, including IL-19, IL-20, IL-22 [IL-10-related T-cell-derived inducible factor (IL-TIF)], IL-24 [melanoma differentiation-associated antigen 7 (MDA-7)] and IL-26 (AK155).
Sabine Wittmann +5 more
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1995
In the 5 years since its discovery, the pleiotropic cytokine IL-10 has been shown to play an important role in the regulation of lymphoid and myeloid cells. IL-10 was detected independently in several laboratories. Fiorentino et al. [1] described a cytokine secreted by ‘type 2’ murine helper T-cell clones which inhibited cytokine production by ‘type 1’
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In the 5 years since its discovery, the pleiotropic cytokine IL-10 has been shown to play an important role in the regulation of lymphoid and myeloid cells. IL-10 was detected independently in several laboratories. Fiorentino et al. [1] described a cytokine secreted by ‘type 2’ murine helper T-cell clones which inhibited cytokine production by ‘type 1’
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A Gly15Arg Mutation in the Interleukin-10 Gene Reduces Secretion of Interleukin-10 in Crohn Disease
Scandinavian Journal of Gastroenterology, 2003Genetic susceptibility, probably involving cytokines and their receptors, plays an important role in inflammatory bowel disease (IBD). In this study we examine the potential role of the interleukin-10 (IL-10) gene as a susceptibility gene in IBD.We studied 17 sib-pairs with either Crohn disease (CD) or ulcerative colitis.
van der Linde, K. +6 more
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BioDrugs, 1997
Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine secreted by several cell types. Most anti-inflammatory effects of IL-10 are caused by its ability to deactivate macrophages and monocytes, whereas its immunosuppressive properties are due to functional inhibition of both antigen-presenting cells and T cells.
Goldman, Michel +2 more
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Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine secreted by several cell types. Most anti-inflammatory effects of IL-10 are caused by its ability to deactivate macrophages and monocytes, whereas its immunosuppressive properties are due to functional inhibition of both antigen-presenting cells and T cells.
Goldman, Michel +2 more
openaire +3 more sources