Results 41 to 50 of about 80,902,661 (299)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Serum IL-6 and IL-10 levels are associated with fatal outcomes in patients with SFTS in China

Journal of Infection in Developing Countries
Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate and is a public health concern.
Xiaoyi Liu, Fan Zhang, Jinping Qiao, Wentao He   +3 more
doaj   +1 more source

Interleukin 10 And 18 levels in Essential Hypertensive

Journal of Applied Sciences and Environmental Management, 2019
The mechanism underlying a sustained blood pressure elevation and its sequelae on the inflammatory cascades have not been totally unraveled. This research was, in addition to body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP ...
O.O. Odewusi, H.B. Osadolor
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neuroprotective effects of interleukin 10 in spinal cord injury

Frontiers in Molecular Neuroscience, 2023
Spinal cord injury (SCI) starts with a mechanical and/or bio-chemical insult, followed by a secondary phase, leading progressively to severe collapse of the nerve tissue.
Juan Li, Pei Wang, Ting Zhou, Wenwen Jiang, Hang Wu, Shengqi Zhang, Lingxiao Deng, Hongxing Wang   +7 more
doaj   +1 more source

Progression of periodontal disease and interleukin-10 gene polymorphism

, 2008
Background and Objective: Interleukin-10 is a key immunoregulatory cytokine that may be of significance in the immunopathogenesis of chronic inflammatory diseases such as periodontal disease.
Middleton, P, Palmer, Janet, Taylor, J, Middleton, PG, Hamlet, Stephen, Cullinan, MP, Westerman, Bill, Taylor, JJ, Cullinan, Mary, Westerman, B, Seymour, GJ, Hamlet, SM, Palmer, JE, Faddy, MJ, Faddy, Malcolm, Seymour, G   +15 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Inhaled Interleukin-10 before and after induction of experimental endotoxemia in the rat : effects on the inflammatory response [PDF]

, 2007
To determine the effects of inhaled IL-10 at different doses and different time points on the pulmonary and systemic inflammatory response during endotoxemia, 48 ventilated, anaesthetized rats (mean body weight ± standard deviation, 500 ± 33g) were ...
Nguyen, Ngoc-Thach
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

The correlation between colorectal cancer rates of proliferation and apoptosis and systemic cytokine levels; plus their influence upon survival [PDF]

, 2006
Colorectal cancer development is associated with a shift in host immunity with suppression of the cell-mediated immune system (CMI) and a predominance of humoral immunity (HI).
Kumar, D, A G Heriot, D Kumar, Evans, C, Finlayson, C, Bartlett, JB, Heriot, AG, I Morrison, A G Dalgleish, Morrison, I, Dalgleish, AG, C Evans, J B Bartlett, C Finlayson   +13 more
core   +1 more source