Results 11 to 20 of about 69,016,899 (249)
Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for people with asthma [PDF]
, 2021 Background: Targeting the immunoglobulin E pathway and the interleukin-5 pathway with specific monoclonal antibodies directed against the cytokines or their receptors is effective in patients with severe asthma.Vyas, A., Nair, P., Wang, R., Gallagher, A., Edwards, M., Evans, D.J.W., Sharma, R., Marsden, P.A., Drew, S. +8 morecore +3 more sourcesAnti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for children and adults with asthma [PDF]
, 2018 This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the efficacy and safety of anti-interleukin-13 or anti-interleukin-4 agents, compared with placebo, anti-Immunoglobulin E agents, or anti-interleukin-5 ...Stewart Drew, Evans, David John William, Andrew Gallagher, Parameswaran Nair, Vyas, Aashish, Drew, Stewart, Edwards, Michaela Jane, Rashmi Sharma, Aashish Vyas, Michaela Edwards, Gallagher, A., Paul A Marsden, Nair, Parameswaran, David JW Evans, Sharma, R, Marsden, Paul +15 morecore +3 more sourcesInterleukin-18 [PDF]
, 2003 Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.McInnes, I.B., Robertson, S.E., Gracie, J.A. +2 morecore +1 more sourceInterleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies [PDF]
, 2012 BACKGROUND: Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades.Thomas, GN, Willeit, P, Trip, MD, Willeit, J, Nelson, Christopher P, Samani, NJ, Danesh, J, Psaty, Bruce M., Assimes, Themistocles L., Stringham, Heather M, Kastelein, JJP, Adamovic, Svetlana, Franks, Paul W., Trip, Mieke D, Harris, Tamara B, Meade, TW, Thomas, Graham; id_orcid, Tivesten, A, de Bakker, PIW, Tybjærg-Hansen, Anne, Boehnke, M, de Bakker, Paul IW, Wilson, Anthony G, Trip, Mieke D., Witteman, Jacqueline C. M., Freitag, DF, Sarwar, Nadeem, Gao, P, Gallacher, John Edward, Ljunggren, Osten, Qi, Lu, Hall, Alistair S., Samani, Nilesh J., Karlsson, Magnus, Hofman, Bert, Goodall, AH, Watkins, H, Arbor, Ann, Davey Smith, George, Chambers, John C, Shaffer, Jonathan A, Butterworth, Adam S., Tracy, Russell P, O'Donnell, CJ, Gorman, Donal N., Psaty, Bruce M, Panagiotakos, DB, Wilde, Arthur AM, Best, LG, Di Angelantonio, Emanuele, Sundstrom, J, Butterworth, AS, Emerging Risk Factors Collaboration (Döring, A. ; Meisinger, C.), Cambien, Francois, Gregson, J, Gorman, Donal N, Best, Lyle G., Manson, JE, Rimm, Eric B, Wennberg, P, de Bakker, Paul I. W., Melzer, D, Qi, L, Gillum, Richard F, Kleber, ME, Gallacher, John, Kastelein, John JP, Chasman, DI, Cambien, F, Ridker, Paul M, Salomaa, Veikko, Hall, AS, Benjamin, Emelia J., Chasman, Daniel I, Salonen, JT, Kaptoge, S, Salonen, Jukka T., O'Donnell, Christopher J., Ingelsson, Erik, Benjamin, Emelia J, Freitag, Daniel F, Rader, Daniel J., Tracy, Russell P., Salonen, Jukka T, Saleheen, D, ?, ?, Salomaa, V, Clarke, Robert, Kleber, Marcus E., Chambers, JC, Witteman, Jacqueline C M, Braund, Peter S., Manson, JoAnn E., Boehnke, Michael, Ouwehand, Willem H, Rendon, A, Wilson, Anthony G., Harari, Olivier, Hopewell, Jemma C., Wilson, AG, Tracy, RP, Karlsson, M, Cantin, B, Reilly, Muredach P., Ohlsson, C, Melzer, David, IL6R Genetics Consortium Emerging Risk Factors Collaboration, Meade, Tom W, Benjamin, EJ, Stringham, Heather M., Freitag, Daniel F., Cantin, Bernard, Gregson, John, Chasman, Daniel I., Butterworth, Adam S, Reich, David, Braund, PS, Schunkert, H, Di Angelantonio, E, Ouwehand, WH, Harris, Tamara B., Thomas, G. Neil, Allin, Kristine H., Nelson, CP, Allin, Kristine Højgaard, Best, Lyle G, de Faire, Ulf, Davey-Smith, George, Kooner, Jaspal S, Gudnason, Vilmundur, Rimm, Eric B., Shaffer, Jonathan A., Sundstrom, Johan, Jansson, JO, Erdmann, Jeanette, Steri, M, Kauhanen, J, Holm, H, Samani, Nilesh J, Nordestgaard, BG, Mellstrom, Dan, Rader, Daniel J, Kaptoge, Stephen, Goodall, Alison H., Meade, Tom W., Clarke, R, Shaffer, JA, Ben-Shlomo, Yoav, Wilson, James F, Witteman, JCM, Ridker, PM, Davey-Smith, G, Tivesten, Asa, Koenig, W, Franks, Paul W.,, O'Donnell, Christopher J, Allin, Kristine H, van der Schoot, CE, Reilly, MP, Asselbergs, FW, Nelson, Christopher P., Hung, J, Danesh, John, Witteman, Jacqueline CM, Gudnason, V, Adamovic, S, Holm, Hilma, Kleber, Marcus E, Cushman, M, Ljunggren, Östen,, Erdmann, J, Koenig, Wolfgang, Rimm, EB, Hung, Joseph, Asselbergs, Folkert W., van der Schoot, C. Ellen, Wassertheil-Smoller, S, Kooner, Jaspal S., Panagiotakos, Demosthenes B, Franks, Paul, Willeit, Peter, Nordestgaard, Børge G, Kooner, JS, Chambers, John C., Tybjaerg-Hansen, Anne, Nordestgaard, Borge G., Tybjaerg-Hansen, A, Kauhanen, Jussi, Wilde, Arthur A. M., Gillum, RF, Watkins, Hugh, Mellstrom, D, Thomas, G Neil, Sarwar, N, de Faire, U, Wilde, AAM, Psaty, BM, Ben-Shlomo, Y, Panagiotakos, Demosthenes B., Ljunggren, O, Harris, TB, Sundström, Johan,, Reilly, Muredach P, Wilde, Arthur A M, Asselbergs, Folkert W, Woodward, Mark, Stringham, HM, Harari, O, Saleheen, Danish, Schunkert, Heribert, Hall, Alistair S, Cushman, Mary, Gorman, DN, Gillum, Richard F., Hopewell, Jemma C, Wilson, JF, IL6R Genetics Consortium, Rader, DJ, Wilson, James F., Kastelein, John J. P., Woodward, M, Hopewell, JC, Hofman, Albert, Rendon, Augusto, Wennberg, Patrik, Jansson, John-Olov, Wilhelmsen, L, Reich, D, Manson, JoAnn E, Onat, A, Amouyel, Philippe, Hamsten, A, Ingelsson, E, Franks, Paul W, Willeit, Johann, Onat, Altan, Wilhelmsen, Lars, Assimes, Themistocles L, Gallacher, J, Wassertheil-Smoller, Sylvia, van der Schoot, C Ellen, Assimes, TL, Goodall, Alison H, Franks, PW, Amouyel, P, Steri, Maristella, Ohlsson, Claes, Braund, Peter S, Allin, KH, Hamsten, Anders, Ridker, Paul M., Ouwehand, Willem H., Gao, Pei, Uitterlinden AG, Stark K, Asselbergs FW, Gregson J, Baumert J, Böhm BO, Kleber ME, Butterworth AS, de Jong JS, Yarnell JW, Danesh J. Collaborators Assimes TL, Wennberg P, Rimm EB, Preuss M, Qi L, Ripatti S, Stefanadis C, Smith AV, Ben Shlomo Y, Rasheed A, Ridker PM, Goodall AH, Karlsson, Magnus,, Kuusisto J, Tikkanen E, Rose LM, Perola M, Dupuis J, Armitage J, Mukamal KJ, Wilson JF, Nordestgaard BG, Hu FB, Jula A, Cheng KK, Reich D, Thorsteinsdóttir U, Thompson PL, Quertermous T, Nieminen MS, Illig T, Lind L, Gallacher J, Tivesten Å, Basu S, Mellström D, Stringham HM, Winkelmann BR, Silveira A, Tivesten, Åsa,, O'Donnell CJ, Whincup PH, Arveiler D, Morris RW, Guralnik JM, Sinisalo J, Maiwald S, Scharnagl H, Jansson JH, van der Schouw YT, Jansson JO, Tuomainen TP, Chasman DI, Freitag DF, Hengstenberg C, Tracy RP, Peden JF, Dehghan A, Fontes JD, Lam TH, Gigante B, Sivapalaratnam S, Hall AS, Harris TB, Lund University., Laakso M, Wilde AA, Nahrstaedt J, Deloukas P, Dagenais GR, Sarwar N, Qu L, Hofman A, Benjamin EJ, Loley C, Kastelein JJ, Rumley A, Heckbert SR, Koenig IR, Beilby JP, Clarke R, Bezzina CR, Amouyel P, Howard BV, Kaptoge S, de Bakker PI, Willenborg C, Shungin D, Schunkert H, Wassertheil Smoller S, Gillum RF, Barroso I, Mellström, Dan,, Gao P, Di Angelantonio E, Tuomilehto J, Cantin B, Shaffer JA, Jansson, John-Olov,, Ingelsson E, Männistö S, Knowles JW, Wilhelmsen L, Singleton AB, Koenig W, Chambers JC, Das D, Davidson KW, Psaty BM, Willeit J, Willeit P, Hlatky MA, Hankinson SE, Schreiber S, Wiggins KL, Panagiotakos DB, Dekker LR, Salonen JT, Manson JE, Thomas GN, Watkins H, Lokki ML, Pai J, Ljunggren Ö, McQuillan BM, Buring J., Adamovic, Svetlana,, Go AS, Gorman DN, Boehnke M, Bis JC, Witteman JC, Adamovic S, Sheikh N, Havulinna AS, Thorleifsson G, Reilly MP, Folsom AR, Sanna S, Fraser R, Meisinger C, Karlsson MK, Kauhanen J, Li M, van Duijn CM, Cambien F, Samani NJ, Davey Smith G, Assimes TL, de Faire U, Meade TW, van der Schoot CE, Verschuren WM, Ohlsson, Claes,, Motazacker M, Allin KH, Sabater Lleal M, Smith NL, Danesh J, Jackson A, Kurl S, Tanck M, Shea SJ, Yin X, Kooner JS, Collins R, Zhang W, Steri M, Thorand B, Saleheen D, CUCCA, Francesco, Gudnason V, Harari O, Melzer D, Onat A, Best LG, Tybjærg Hansen A, Nelson CP, Onland Moret NC, Franks PW, Rosengren A, Karlsson M, Erdmann J, Basart H, Wannamethee SG, Salomaa V, Ouwehand WH, Trip MD, Woodward M, Rendon A, Parish S, Balmforth AJ, Braund PS, Stefansson K, Abecasis GR, Ohlsson C, Sundström J, Hveem K, Hólm H, Ferrucci L, Syvänen AC, Hallmans G, Hopewell JC, Lowe G, Pitsavos C, Kiechl S, Farrall M, Thorgeirsson G, Hamsten A, Rader DJ, Boer JM, Franks, Paul,, Jiang CC, Chrysohoou C, Hung J, Bandinelli S, Schlessinger D, März W, Uda M, Cushman M, Wilson AG, Thompson JR, Qasim A, Sarwar, N;Butterworth, AS;Freitag, DF;Gregson, J;Willeit, P;Gorman, DN;Gao, P;Saleheen, D;Rendon, A;Nelson, CP;Braund, PS;Hall, AS;Chasman, DI;Tybjærg-Hansen, A;Chambers, JC;Benjamin, EJ;Franks, PW;Clarke, R;Wilde, AA;Trip, MD;Steri, M;Witteman, JC;Qi, L;van der Schoot, CE;de Faire, U;Erdmann, J;Stringham, HM;Koenig, W;Rader, DJ;Melzer, D;Reich, D;Psaty, BM;Kleber, ME;Panagiotakos, DB;Willeit, J;Wennberg, P;Woodward, M;Adamovic, S;Rimm, EB;Meade, TW;Gillum, RF;Shaffer, JA;Hofman, A;Onat, A;Sundström, J;Wassertheil-Smoller, S;Mellström, D;Gallacher, J;Cushman, M;Tracy, RP;Kauhanen, J;Karlsson, M;Salonen, JT;Wilhelmsen, L;Amouyel, P;Cantin, B;Best, LG;Ben-Shlomo, Y;Manson, JE;Davey-Smith, G;de Bakker, PI;O'Donnell, CJ;Wilson, JF;Wilson, AG;Assimes, TL;Jansson, JO;Ohlsson, C;Tivesten, Å;Ljunggren, Ö;Reilly, MP;Hamsten, A;Ingelsson, E;Cambien, F;Hung, J;Thomas, GN;Boehnke, M;Schunkert, H;Asselbergs, FW;Kastelein, JJ;Gudnason, V;Salomaa, V;Harris, TB;Kooner, JS;Allin, KH;Nordestgaard, BG;Hopewell, JC;Goodall, AH;R, Campbell H, Wild S, Kooner AS +489 morecore +1 more sourceThe Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma
Frontiers in Pharmacology, 2019 Approximately 5–10% of asthmatic patients worldwide suffer from severe asthma. Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in chronic airways inflammation.Giancarlo Marone, Giancarlo Marone, Francescopaolo Granata, Francescopaolo Granata, Valentina Pucino, Antonio Pecoraro, Enrico Heffler, Enrico Heffler, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Guy W. Scadding, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi +14 moredoaj +1 more sourceReal-life effects of dupilumab in patients with severe type 2 asthma, according to atopic trait and presence of chronic rhinosinusitis with nasal polyps
Frontiers in Immunology, 2023 BackgroundThe efficacy of dupilumab as biological treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) depends on its ability to inhibit the pathophysiologic mechanisms involved in type 2 inflammation.ObjectiveTo assess in a ...Corrado Pelaia, Alida Benfante, Maria Teresa Busceti, Maria Filomena Caiaffa, Raffaele Campisi, Giovanna Elisiana Carpagnano, Nunzio Crimi, Maria D’Amato, Maria Pia Foschino Barbaro, Angelantonio Maglio, Elena Minenna, Santi Nolasco, Giuseppe Paglino, Francesco Papia, Girolamo Pelaia, Andrea Portacci, Luisa Ricciardi, Nicola Scichilone, Giulia Scioscia, Massimo Triggiani, Giuseppe Valenti, Alessandro Vatrella, Claudia Crimi +22 moredoaj +1 more source
