Results 21 to 30 of about 69,016,899 (249)

Club cell-derived brain-derived neurotrophic factor regulates murine airway mechanics and mucin production in response to IL-13 in a sex-dependent manner

Frontiers in Physiology
IntroductionBrain-derived neurotrophic factor (BDNF) is a neural plasticity molecule that is increasingly recognized for its role in airway pathophysiology, including diseases like asthma.
Amy Fagan, Mariana Sponchiado, Luz Mata, Shanil Amin, J. Ignacio Aguirre, Sreekala Prabhakaran, Leah R. Reznikov   +6 more
doaj   +1 more source

Tick-Borne Encephalitis Specific Lymphocyte Response after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Humoral Immunity after Vaccination

Vaccines, 2021
The aim of this prospective study was to assess lymphocyte proliferative and cytokine response prior to and following tick-borne encephalitis (TBE) immunization among patients after allogeneic hematopoietic stem cell transplantation (HSCT).
Nicole Harrison, Katharina Grabmeier-Pfistershammer, Alexandra Graf, Doris Trapin, Peter Tauber, Judith H. Aberle, Karin Stiasny, Ralf Schmidt, Hildegard Greinix, Werner Rabitsch, Michael Ramharter, Heinz Burgmann, Winfried F. Pickl, Christina Bahrs   +13 more
doaj   +1 more source

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor [PDF]

, 2011
Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen.
Saralili Dipa Robertson, Sofat, N, Nidhi Sofat, Wait, R, Robertson, SD, Robin Wait   +5 more
core   +1 more source

Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency [PDF]

, 1994
Human interleukin-4 possesses two distinct sites for receptor activation. A signaHing site, comprising residues near the C-terminus on helix D, determines the efficacy of interleukin-4 signal transduction without affecting the binding to the interleukin ...
Reusch, P., Shen, B. J., Sebald, Walter, Tony, H. P.   +3 more
core   +1 more source

In vitro initial immune response against Leishmania amazonensis infection is characterized by an increased production of IL-10 and IL-13

Brazilian Journal of Infectious Diseases
The initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production.
Zirlane Castelo B Coêlho, Maria Jania Teixeira, Erika Freitas Mota, Mércia Sindeaux Frutuoso, João Santana da Silva, Aldina Barral, Manoel Barral-Netto, Margarida Maria L Pompeu   +7 more
doaj   +1 more source

Searching for Noninvasive Predictors of the Diagnosis and Monitoring of Eosinophilic Esophagitis—The Importance of Biomarkers of the Inflammatory Reaction Involving Eosinophils

Biomolecules, 2021
Background: Invasive and costly endoscopic diagnosis is obligatory for the diagnosis and monitoring of eosinophilic esophagitis (EoE). This study aims to evaluate the usefulness of serum biomarkers involved in eosinophil-mediated inflammation in the ...
Joanna Sarbinowska, Benita Wiatrak, Dorota Waśko-Czopnik   +2 more
doaj   +1 more source

Anti-aminoacyl-tRNA synthetase-interacting multifunctional protein-1 antibody improves airway inflammation in mice with house dust mite induced asthma

World Allergy Organization Journal
Background: Several biologics have been developed and used to treat severe asthma. However, commercialized biologics have limitations in treating T2-low asthma because their main target is the T2 inflammation marker. Therefore, there is an unmet need for
Sung-Ryeol Kim, MD, Yun Jung Um, MSc, Sook In Chung, PhD, Kyoung Yong Jeong, PhD, Hye Jung Park, MD, Kyung Hee Park, MD, Jung-Won Park, MD, Sang Gyu Park, PhD, Jae-Hyun Lee, MD   +8 more
doaj   +1 more source

Lack of association between interleukin 13, interleukin 4 receptor alpha, andMS4A2 gene polymorphisms and asthma in adult Saudis

Journal of Nature and Science of Medicine, 2020
Objectives: Several genes, including interleukin-13 (IL13), MS4A2, and IL 4 receptor alpha (IL4Rα), have been shown to associate with the inflammatory process in asthma.
Eman A Al Abdulsalam, Mohamed S Al-Hajjaj, Mohammad S Alanazi, Arjumand S Warsy   +3 more
doaj   +1 more source

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction

, 2009
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies, Holgate, Stephen T, Isabelle Kirby, Ida Karin Nordgren, Tavassoli, Ali, Davies, Donna E, Holloway, John W, Andrews, Allison-Lynn, Stephen T. Holgate, Nordgren, Ida Karin, John W. Holloway, Kirby, Isabelle, Allison-Lynn Andrews, Ali Tavassoli   +13 more
core   +1 more source

Th17 Lymphocytes in Respiratory Syncytial Virus Infection

Viruses, 2013
Infection by respiratory syncytial virus (RSV) affects approximately 33 million infants annually worldwide and is a major cause of hospitalizations. Helper T lymphocytes (Th) play a central role in the immune response during such infections.
Rizgar A. Mageed, Ali S. Jawad, Mohammed Al-Bogami, Nasra Al-Adhoubi, Jonas Bystrom   +4 more
doaj   +1 more source