Results 21 to 30 of about 580,329 (259)
Association of interleukin-13 gene variants with susceptibility to brucellosis [PDF]
Trends in Pharmaceutical Sciences, 2016 Brucella is an intracellular Gram-negative bacterium. Previous reports showed that gene polymorphisms of cytokines can affect resistance or susceptibility to Brucella infection.
Sayed-Jalal-Aladin Ashraf-Mansuri +5 more
doaj +3 more sources
Viruses, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
John Foerster, Aleksandra Molęda
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Pharmaceutical Biology, 2020 Context Airway remodelling is one of the most refractory problems in asthma. According to the critical roles of oxidative stress and inflammation in airway remodelling, it is supposed that ascorbic acid and calcitriol have beneficial effects.
Farzaneh Kianian +5 more
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Neuroimmunology of the Interleukins 13 and 4 [PDF]
Brain Sciences, 2016 The cytokines interleukin 13 and 4 share a common heterodimeric receptor and are important modulators of peripheral allergic reactions. Produced primarily by T-helper type 2 lymphocytes, they are typically considered as anti-inflammatory cytokines because they can downregulate the synthesis of T-helper type 1 pro-inflammatory cytokines.
Simone Mori, Pamela Maher, Bruno Conti
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Cytokine profile associated with human chronic schistosomiasis mansoni
Memorias do Instituto Oswaldo Cruz, 2004 This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients.
Andréa Magalhães +9 more
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Interleukin-4 receptor alpha gene variants and allergic disease
Respiratory Research, 2000 The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual.
Hall Ian P
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The Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma
Frontiers in Pharmacology, 2019 Approximately 5–10% of asthmatic patients worldwide suffer from severe asthma. Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in chronic airways inflammation.
Giancarlo Marone +14 more
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BMC Pregnancy and Childbirth, 2023 Background Preeclampsia is the main cause of preterm parturition and maternal–fetal complications. T helper 1 and T helper 2 cytokines balance is a requirement in normal pregnancy and aberrant in this immunologic balance, play an important role in the ...
Sara Parhoudeh +5 more
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Frontiers in Immunology, 2023 BackgroundThe efficacy of dupilumab as biological treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) depends on its ability to inhibit the pathophysiologic mechanisms involved in type 2 inflammation.ObjectiveTo assess in a ...
Corrado Pelaia +22 more
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Frontiers in PhysiologyIntroductionBrain-derived neurotrophic factor (BDNF) is a neural plasticity molecule that is increasingly recognized for its role in airway pathophysiology, including diseases like asthma.
Amy Fagan +6 more
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