Results 261 to 270 of about 899,292 (304)
Some of the next articles are maybe not open access.
Current Opinion in Pulmonary Medicine, 2003
Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of the allergic response. Initial studies in animal models of disease provided compelling evidence that IL-13, independent from other Th2 cytokines, was necessary and sufficient to induce all features of allergic asthma.
Marsha, Wills-Karp, Monica, Chiaramonte
openaire +2 more sources
Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of the allergic response. Initial studies in animal models of disease provided compelling evidence that IL-13, independent from other Th2 cytokines, was necessary and sufficient to induce all features of allergic asthma.
Marsha, Wills-Karp, Monica, Chiaramonte
openaire +2 more sources
Current Protocols in Immunology, 2001
AbstractThis unit describes two protocols that can be used to quantitate interleukin‐13 (IL‐13). The enzyme‐linked immunosorbent assay (ELISA) has the advantage of being highly specific for human IL‐13 and does not recognize other cytokines present in the sample.
Angus, Lauder, Andrew N J, McKenzie
openaire +2 more sources
AbstractThis unit describes two protocols that can be used to quantitate interleukin‐13 (IL‐13). The enzyme‐linked immunosorbent assay (ELISA) has the advantage of being highly specific for human IL‐13 and does not recognize other cytokines present in the sample.
Angus, Lauder, Andrew N J, McKenzie
openaire +2 more sources
[Interleukin 13 and interleukin 13 receptor involvement in systemic sclerosis].
La Revue de medecine interne, 2007Interleukin 13 is an immunoregulatory cytokine predominantly secreted by activated Th2 cells. It has similar functions with interleukin 4 and they share a common receptor. However, unlike interleukin 4, l'interleukin 13 does not appear to be important in the initial differentiation of CD4 T into Th2-type cells, but rather appears to be necessary in the
Granel, B., Chevillard, C., Dessein, A.
openaire +2 more sources
Interleukin-4 and Interleukin-13 Signaling Connections Maps
Science, 2003Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy.
Ann E, Kelly-Welch +3 more
openaire +2 more sources
Interleukin-13 in asthma pathogenesis
Current Allergy and Asthma Reports, 2004Summary: Bronchial asthma is a complex disorder that is thought to arise as a result of aberrant T‐lymphocyte responses to noninfectious environmental antigens. In particular, the symptoms of asthma are closely associated with the presence of activated T‐helper 2 cell (Th2) cytokine‐producing cells [interleukin (IL)‐4, IL‐5, IL‐9, and IL‐13] in the ...
openaire +3 more sources
1995
Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
openaire +1 more source
Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
openaire +1 more source
Role of Interleukin-13 in Asthma
Current Allergy and Asthma Reports, 2013Interleukin-13 is a pleiotropic TH2 cytokine that has been shown to be central to the pathogenesis of asthma. Some of the most prominent of the effects of IL-13 include increases in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness, and switching of B cell antibody production from IgM to IgE.
openaire +2 more sources
Journal of Receptors and Signal Transduction, 1999
Synovial fibroblasts expressed transcripts for IL-4R alpha, and IL-13R alpha 1 and IL-13R alpha 2. Using weighted nonlinear computer modeling of the data from equilibrium binding studies, a 2 bindings sites model fitted the data best. After occupation of the shared high affinity receptors by the non-signaling, double mutant IL-4(121)R-->D, 124Y-->D (RY-
R A, Lutz, N, Feng, R, Moser
openaire +2 more sources
Synovial fibroblasts expressed transcripts for IL-4R alpha, and IL-13R alpha 1 and IL-13R alpha 2. Using weighted nonlinear computer modeling of the data from equilibrium binding studies, a 2 bindings sites model fitted the data best. After occupation of the shared high affinity receptors by the non-signaling, double mutant IL-4(121)R-->D, 124Y-->D (RY-
R A, Lutz, N, Feng, R, Moser
openaire +2 more sources
Immunoregulatory Roles of Interleukin-13 in Cattle
Journal of Interferon & Cytokine Research, 1999Interleukin-13 (IL-13) is produced predominantly by helper T lymphocytes of the Th2 phenotype and mediates its effects on several immune cells, including B lymphocytes and macrophages, stimulating their proliferation, differentiation, and effector functions.
W L, Trigona +3 more
openaire +2 more sources
Transgenic Modeling of Interleukin-13 in the Lung
Chest, 2003Interleukin (IL)-13 is a key cytokine in asthma pathogenesis. We used constitutive and inducible overexpression transgenic mice to characterize the mechanisms by which IL-13 causes phenotypic alterations in the lung. These studies demonstrated that chemokine receptor-2, transforming growth factor-beta(1), and IL-11 play an important role in the ...
Jack A, Elias +7 more
openaire +2 more sources