Results 21 to 30 of about 387,985 (305)

Guselkumab, tildrakizumab, and risankizumab in a real-world setting: drug survival and effectiveness in the treatment of psoriasis and psoriatic arthritis

Journal of Dermatological Treatment, 2023
Background Clinical trials have shown promising results for interleukin-23 inhibitors in the treatment of psoriasis. The drugs have been used in clinical practice since 2017.
Cathrine Dawn Büttner Elgaard, Lars Iversen, Kasper Fjellhaugen Hjuler   +2 more
doaj   +1 more source

Overcoming steroid resistance in T cell acute lymphoblastic leukemia [PDF]

, 2016
In a Perspective, Pieter Van Vlierberghe and Steven Goossens discuss Meijerink and colleagues' findings on steroid resistance in pediatric T cell acute lymphoblastic ...
Goossens, Steven, Van Vlierberghe, Pieter   +1 more
core   +3 more sources

AUTOINFLAMMATORY DISEASES IN RHEUMATOLOGY: RUSSIAN EXPERIENCE

Научно-практическая ревматология, 2016
Autoinflammatory diseases (AIDs) are characterized by periodic, sometimes self-limiting attacks that appear as fever and clinical symptoms resembling rheumatic ones, in the absence of autoimmune or infectious diseases.
S. O. Salugina, E. S. Fedorov, N. N. Kuzmina, E. A. Kamenets, E. Yu. Zakharova   +4 more
doaj   +1 more source

IL-1β Inhibition in Cardiovascular Complications Associated to Diabetes Mellitus

Frontiers in Pharmacology, 2017
Diabetes mellitus (DM) is a chronic disease that affects nowadays millions of people worldwide. In adults, type 2 diabetes mellitus (T2DM) accounts for the majority of all diagnosed cases of diabetes.
Concepción Peiró, Concepción Peiró, Óscar Lorenzo, Óscar Lorenzo, Raffaele Carraro, Raffaele Carraro, Raffaele Carraro, Carlos F. Sánchez-Ferrer, Carlos F. Sánchez-Ferrer   +8 more
doaj   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber, Boer, Chung, Decker, Gabrilove, Gonzalez, Goodnough, Gotoh, Haq, Jain, Jain, Jonk, Kaptein, Kirito, Kirito, Kirito, Lim, Millot, Miyazaki, Mulcahy, Ng, Schuringa, Schuringa, Schuringa, Smithgall, Socolovsky, Teglund, Tilbrook, Turkson, Watowich, Wen, Wen, Woetmann, Yokogami, Youssoufian, Yu, Zhang   +36 more
core   +1 more source

Immunomodulatory drug therapy for the disease caused by SARS-CoV-2 infection (COVID-19)

Alʹmanah Kliničeskoj Mediciny, 2020
This systematic review focuses on the state-of-the-art pharmacotherapy of immune disorders in the novel coronavirus infection (COVID-19), leading to a cytokine storm and uncontrolled inflammatory response that causes severe tissue damage and multiple ...
D. E. Karateev, E. L. Luchikhina
doaj   +1 more source

Emerging targets in human lymphoma: targeting the MYD88 mutation [PDF]

, 2016
B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link ...
Horikawa, Keisuke, Jeelall, Yogesh S., Wang, James Q.   +2 more
core   +1 more source

Comparative analysis of IL-1β blood serum concentration, neutrophil-to-lymphocytes ratio in peripheral blood, and the levels of PD-L1 expression in malignant tissues of the patients with various solid tumors

Медицинская иммунология, 2021
The action of checkpoint inhibitors is based on activation of T cell antitumor immunity, and, therefore, the search for markers of lymphocyte functional activity before starting the therapy is highly relevant.
R. V. Orlova, N. V. Zhukova, A. M. Malkova, E. A. Kaledina, A. R. Gubal, V. V. Sharoiko   +5 more
doaj   +1 more source

Constitutive cytoplasmic localization of p21Waf1/Cip1 affects the apoptotic process in monocytic leukaemia [PDF]

, 2003
In the present study, we analysed the expression and localization of p21Waf1/Cip1 in normal and malignant haematopoietic cells. We demonstrate that in normal monocytic cells, protein kinase C (PKC)-induced p21 gene activation, which is nuclear factor-κB (
A de Thonel, A Rambaldi, A Suzuki, A Suzuki, A Suzuki, A Suzuki, AS Baldwin Jr, CD Bloomfield, D Toullec, E Kobayashi, E Schreiber, H Ichijo, HY Chang, J Chen, J Chen, J Lin, JE Thompson, JJ Schuringa, JM Bennett, JM Herbert, JM Lai, K Kuno, K Kuno, KN Pennington, KU Birkenkamp, KU Birkenkamp, KU Birkenkamp, L Koenderman, L Rossig, LM Tuyt, M Asada, M Asada, M Mizuki, M Nakanishi, ML Guzman, MT Scott, MV Blagosklonny, MW Mayo, PJ Fialkow, RA Steinman, TS Finco, Y Arvidsson, Y Li, Y Luo, Y Miyazaki   +44 more
core   +3 more sources

A clinical case of adult-onset Still's disease resistant to therapy with tumor necrosis factor-alpha inhibitors and interleukin-6 inhibitors

Современная ревматология, 2019
The basis of the clinical picture of adult-onset Still's disease is a triad of symptoms, includingfever, arthralgia/arthritis, and characteristic rash called «Still rash».
R. R. Samigullina, E. A. Vasilenko, V. I. Mazurov   +2 more
doaj   +1 more source