Results 11 to 20 of about 238,614 (342)

Interleukin-1 Receptor Antagonist Protects Newborn Mice Against Pulmonary Hypertension

Frontiers in Immunology, 2019
Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions.
Christine B. Bui, Christine B. Bui, Magdalena Kolodziej, Emma Lamanna, Kirstin Elgass, Arvind Sehgal, Arvind Sehgal, Ina Rudloff, Ina Rudloff, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Maurice A. G. M. Kroon, Maurice A. G. M. Kroon, Steven X. Cho, Steven X. Cho, Anton Maksimenko, Marian Cholewa, Philip J. Berger, Philip J. Berger, Morag J. Young, Jane E. Bourke, James T. Pearson, James T. Pearson, Marcel F. Nold, Marcel F. Nold, Claudia A. Nold-Petry, Claudia A. Nold-Petry   +26 more
doaj   +2 more sources

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist [PDF]

New England Journal of Medicine, 2009
Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations of IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement of skin and bone.We studied nine children from six families who had neonatal onset of ...
Deborah L. Stone, Peter K. Gregersen, Paul Babyn, Daniel C. Douek, Ulf Tedgård, Daniel L. Kastner, Dawn Chapelle, Kamal Ohson, Matthew G. Booty, Barbara Yang, Massimo Gadina, Netanya G. Sandler, Elaine F. Remmers, A. Elisabeth Hak, John A. Butman, Arian Laurence, Ivona Aksentijevich, Benjamin D. Korman, P. Martin van Hagen, Hatem El-Shanti, Chyi-Chia Richard Lee, Seth L. Masters, Maria L. Turner, Edward W. Cowen, Proton Rahman, Marc Nicholson, Xinyu Bing, Jacob D. Estes, Suvimol Hill, Polly J. Ferguson, Marjan Huizing, Elena Pope, Paul Dancey, Karyl S. Barron, Nicole Plass, R. M. Laxer, Annet van Royen-Kerkhoff, Joost Frenkel, Raphaela Goldbach-Mansky, Rayfel Schneider, Gillian I. Clarke, Tuyet-Hang Pham   +41 more
openaire   +5 more sources

Investigation of the Relationship Between IL-1Ra VNTR Variants and Psoriasis

Haseki Tıp Bülteni, 2021
Aim:Psoriasis is an inflammatory skin disease characterized by hyperproliferation of keratinocytes. The imbalance between Interleukin-1 (IL-1)/IL-1 receptor antagonist (IL-1Ra) is associated with increased pro-inflammatory cytokine production and the ...
Aysegul Basak Akadam Teker, Burak Aksan
doaj   +1 more source

IL1RN (interleukin 1 receptor antagonist) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014
Review on IL1RN, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Gómez-Flores-Ramos, L, Torres-Flores, J, Gallegos-Arreola, MP   +2 more
openaire   +2 more sources

Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns

Journal of Neuroinflammation, 2018
Background Hypothermia is increasingly tested in several neurological conditions, such as neonatal encephalopathy, stroke, traumatic brain injury, subarachnoid hemorrhage, spinal cord injury, and neurological outcomes of cardiac arrest.
Mathilde Chevin, Clémence Guiraut, Guillaume Sébire   +2 more
doaj   +1 more source

Treatment to Target Using Recombinant Interleukin‐1 Receptor Antagonist as First‐Line Monotherapy in New‐Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five‐Year Follow‐Up Study

Arthritis & Rheumatology, 2019
Systemic juvenile idiopathic arthritis (JIA) is a multifactorial autoinflammatory disease with a historically poor prognosis. With current treatment regimens, approximately half of patients still experience active disease after 1 year of therapy.
N. T. ter Haar, E. H. Pieter Dijkhuizen, J. Swart, A. Royen-Kerkhof, Ayman el Idrissi, Arjen P. Leek, W. Jager, M. C. H. Groot, S. Haitjema, D. Holzinger, D. Foell, J. Loosdregt, N. Wulffraat, S. Roock, S. Vastert   +14 more
semanticscholar   +1 more source

Regulation of energy metabolism by interleukin-1 β, but not by interleukin-6, is mediated by nitric oxide in primary cultured rat hepatocytes [PDF]

, 1996
The effects of inflammatory cytokines (interleukin-1 β, interleukin-6, and tumor necrosis factor-α) on energy metabolism were studied in primary cultured rat hepatocytes. Adenine nucleotide (ATP, ADP, and AMP) content, lactate production, the ketone body
Hiramatsu, Yoshifumi, Inoue, Kyoichi, Ito, Seiji, Kamiya, Tomoo, Kamiyama, Yasuo, Kanemaki, Toshiki, Kitade, Hiroaki, Matsui, Yoichi, Nakagawa, Manabu, Okumura, Tadayoshi, Sakitani, Kazushige   +10 more
core   +1 more source

Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

New England Journal of Medicine, 2007
BACKGROUND The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading ...
C. Larsen, M. Faulenbach, A. Vaag, A. Vølund, J. Ehses, B. Seifert, T. Mandrup-Poulsen, M. Donath   +7 more
semanticscholar   +2 more sources

Evaluation of the Interleukin-1 Receptor Antagonist and Immunoregulatory Interleukin-10 in the Middle Ear in Chronic Otitis Media With Effusion in Children With and Without Atopy [PDF]

Clinical and Experimental Otorhinolaryngology, 2016
Objectives The role of pro-inflammatory cytokines in the course of chronic otitis media with effusion (COME) has been documented. However, there are fewer studies on the action of anti-inflammatory cytokines in the middle ear. We sought determine whether
Beata Zielnik-Jurkiewicz, Wanda Stankiewicz-Szymczak   +1 more
doaj   +1 more source

Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Applied Sciences, 2022
Recent studies report that individuals with polymorphisms in the genes that encode for interleukin (IL)-1α and IL-1β (IL-1A and IL1B, respectively) and for IL-1 receptor antagonist (IL-1RN) may be more susceptible in developing peri-implantitis ...
José Maria Cardoso, Sofia Duarte, Ana Clara Ribeiro, Paulo Mascarenhas, Susana Noronha, Ricardo Castro Alves   +5 more
doaj   +1 more source