Results 191 to 200 of about 161,275 (301)

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3. [PDF]

Stem Cell Res Ther
Song J, Han Y, Chen Y, Cheng L, Xiao J, Li A, Kong D, Jiang Y, Zheng C.   +8 more
europepmc   +1 more source

The Role of Interleukin-1-Receptor-Antagonist in Bladder Cancer Cell Migration and Invasion. [PDF]

Int J Mol Sci, 2021
Schneider L, Liu J, Zhang C, Azoitei A, Meessen S, Zheng X, Cremer C, Gorzelanny C, Kempe-Gonzales S, Brunner C, Wezel F, Bolenz C, Gunes C, John A.   +13 more
europepmc   +1 more source

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

Interleukin 1 Receptor Antagonist (IL-1ra) Production and Expression Dynamics in Mammary Glands After Lipopolysaccharide Infusion. [PDF]

Anim Sci J
Marufah NL, Nii T, Suzuki N, Jaisue J, Isobe N.   +4 more
europepmc   +1 more source

IL-1 receptor antagonist attenuates proinflammatory responses to rhinovirus in airway epithelium. [PDF]

J Allergy Clin Immunol, 2023
Schworer SA, Chason KD, Chen G, Chen J, Zhou H, Burbank AJ, Kesic MJ, Hernandez ML.   +7 more
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Adenosine deaminase and interleukin-1 receptor antagonist genetic polymorphisms among obese children with versus without metabolic dysfunction-associated fatty liver disease. [PDF]

Clin Exp Pediatr
Sakhr HM, Hassan MH, Taha AM, Bakri AH.
europepmc   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study. [PDF]

Br J Anaesth
EPIFEVER-2 investigators.
europepmc   +1 more source