Results 301 to 310 of about 158,089 (347)
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Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective
Biochemical and Biophysical Research Communications, 1997Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream.
Loddick, Sarah A.+5 more
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Interleukin-1 Receptor Antagonist Expression in Sarcoidosis
American Review of Respiratory Disease, 1993Sarcoidosis is a systemic granulomatous disease with a marked propensity for involvement of the pulmonary parenchyma and thoracic lymphatic system. This granulomatous process is characterized by aggregations of mononuclear cells, multinucleated giant cells, and variable degrees of fibrosis.
Joseph P. Lynch+6 more
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Interleukin-1 receptor antagonist: effectiveness against interleokin-1 fever
Canadian Journal of Physiology and Pharmacology, 1992Conscious cats were used to examine the effectiveness of the interleukin-1 receptor antagonist against the fever induced by interleukin-1 and endotoxin. Although inactive by itself, the antagonist (three 1-μg bolus injections at 10-min intervals), injected into the third ventricle, attenuated the febrile response to a subsequent ...
COCEANI, Flavio+3 more
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INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology
Annual Review of Immunology, 1998▪ Abstract The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18-kDa form ...
Carla J. Guthridge+3 more
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Interleukin‐1 receptor antagonist in the fetomaternal compartment
Acta Paediatrica, 1995Interleukin‐1 (IL‐1) is a major mediator in infections and inflammation. Interleukin‐1 receptor antagonist (IL‐1ra) opposes the actions of IL‐1. IL‐1ra is present in exceptionally high concentrations in third trimester amniotic fluid. We studied IL‐1ra in amniotic fluid, fetal serum and newborn urine.
Urpo Lappalainen+4 more
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Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist
International Reviews of Immunology, 1998IL-1 (IL-1 alpha or IL-1 beta) is the prototypic "multifunctional" cytokine. Unlike the lymphocyte and colony stimulating growth factors, IL-1 affects nearly every cell type, and often in concert with other cytokines or small mediator molecules. Although some lymphocyte and colony stimulating growth factors may be therapeutically useful, IL-1 is a ...
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Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Nature, 1990Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations ...
Patricia L. Heimdal+9 more
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Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer
Gynecologic Oncology, 1991The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. A secreted IL-1 receptor antagonist (sIL-1ra) has been described and an intracellular version (icIL-1ra) has been cloned; both antagonists block IL-1-dependent responses.
W.C. Fowler+7 more
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Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.
Alimentary Pharmacology & Therapeutics, 1996Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
Theresa T. Pizarro, Fabio Cominelli
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Febrile Seizures: Interleukin 1β and Interleukin-1 Receptor Antagonist Polymorphisms
Pediatric Neurology, 2009In order to investigate the association between IL-1beta -511 C-->T and IL-1 receptor antagonist intron 2 variable tandem repeat polymorphisms, and febrile seizures in children, 90 children (mean age, 19.7 +/- 11.2 months) diagnosed with febrile seizure and 106 healthy controls (mean age, 14.2 +/- 3.6 months) with no seizure or neurologic events were ...
Serdaroglu G.+6 more
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