Results 301 to 310 of about 158,089 (347)

Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

Biochemical and Biophysical Research Communications, 1997
Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream.
Loddick, Sarah A., Wong, Ma Li, Bongiorno, Peter B., Gold, Philip W., Licinio, Julio, Rothwell, Nancy J.   +5 more
openaire   +4 more sources

Interleukin-1 Receptor Antagonist Expression in Sarcoidosis

American Review of Respiratory Disease, 1993
Sarcoidosis is a systemic granulomatous disease with a marked propensity for involvement of the pulmonary parenchyma and thoracic lymphatic system. This granulomatous process is characterized by aggregations of mononuclear cells, multinucleated giant cells, and variable degrees of fibrosis.
Joseph P. Lynch, Theodore J. Standiford, Andrew R. Gilbert, Steven L. Kunkel, Mark W. Rolfe, Marie D. Burdick, Robert M. Strieter   +6 more
openaire   +2 more sources

Interleukin-1 receptor antagonist: effectiveness against interleokin-1 fever

Canadian Journal of Physiology and Pharmacology, 1992
Conscious cats were used to examine the effectiveness of the interleukin-1 receptor antagonist against the fever induced by interleukin-1 and endotoxin. Although inactive by itself, the antagonist (three 1-μg bolus injections at 10-min intervals), injected into the third ventricle, attenuated the febrile response to a subsequent ...
COCEANI, Flavio, LEES J, REDFORD J, BISHAI I.   +3 more
openaire   +4 more sources

INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology

Annual Review of Immunology, 1998
▪ Abstract  The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18-kDa form ...
Carla J. Guthridge, William P. Arend, Cem Gabay, Mark Malyak   +3 more
openaire   +3 more sources

Interleukin‐1 receptor antagonist in the fetomaternal compartment

Acta Paediatrica, 1995
Interleukin‐1 (IL‐1) is a major mediator in infections and inflammation. Interleukin‐1 receptor antagonist (IL‐1ra) opposes the actions of IL‐1. IL‐1ra is present in exceptionally high concentrations in third trimester amniotic fluid. We studied IL‐1ra in amniotic fluid, fetal serum and newborn urine.
Urpo Lappalainen, Kristina Bry, Feizal Waffarn, K Teramo, Mikko Hallman   +4 more
openaire   +3 more sources

Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

International Reviews of Immunology, 1998
IL-1 (IL-1 alpha or IL-1 beta) is the prototypic "multifunctional" cytokine. Unlike the lymphocyte and colony stimulating growth factors, IL-1 affects nearly every cell type, and often in concert with other cytokines or small mediator molecules. Although some lymphocyte and colony stimulating growth factors may be therapeutically useful, IL-1 is a ...
openaire   +2 more sources

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

Nature, 1990
Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations ...
Patricia L. Heimdal, Andreas Sommer, Lyman G Armes, Hannum Charles H, Joslin Fenneke G, Stephen P. Eisenberg, Robert C. Thompson, William P. Arend, Carol J. Wilcox, David Dripps   +9 more
openaire   +3 more sources

Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer

Gynecologic Oncology, 1991
The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. A secreted IL-1 receptor antagonist (sIL-1ra) has been described and an intracellular version (icIL-1ra) has been cloned; both antagonists block IL-1-dependent responses.
W.C. Fowler, W.C. Fowler, Glenn J. Jaffe, Glenn J. Jaffe, Stephen Haskill, Stephen Haskill, Linda Van Le, Linda Van Le   +7 more
openaire   +3 more sources

Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.

Alimentary Pharmacology & Therapeutics, 1996
Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
Theresa T. Pizarro, Fabio Cominelli
openaire   +2 more sources

Febrile Seizures: Interleukin 1β and Interleukin-1 Receptor Antagonist Polymorphisms

Pediatric Neurology, 2009
In order to investigate the association between IL-1beta -511 C-->T and IL-1 receptor antagonist intron 2 variable tandem repeat polymorphisms, and febrile seizures in children, 90 children (mean age, 19.7 +/- 11.2 months) diagnosed with febrile seizure and 106 healthy controls (mean age, 14.2 +/- 3.6 months) with no seizure or neurologic events were ...
Serdaroglu G., Alpman A., Tosun A., Pehlivan S., Özkınay F., Tekgül H., Gökben S.   +6 more
openaire   +4 more sources