Results 301 to 310 of about 167,720 (353)
Some of the next articles are maybe not open access.
Febrile Seizures: Interleukin 1β and Interleukin-1 Receptor Antagonist Polymorphisms
Pediatric Neurology, 2009In order to investigate the association between IL-1beta -511 C-->T and IL-1 receptor antagonist intron 2 variable tandem repeat polymorphisms, and febrile seizures in children, 90 children (mean age, 19.7 +/- 11.2 months) diagnosed with febrile seizure and 106 healthy controls (mean age, 14.2 +/- 3.6 months) with no seizure or neurologic events were ...
Serdaroglu G. +6 more
openaire +3 more sources
lnterleukin-1 Receptor Antagonist
Critical Reviews™ in Immunology, 1995The interleukin-1 receptor antagonist (IL-1ra) is unusual in that it is the only known naturally occurring, cytokine receptor antagonist with no apparent agonist function. Over the last 5 years, since the cloning of the IL-1ra cDNA sequence, there has been intensive research on the genetics, regulation, and potential therapeutic value of this protein ...
openaire +3 more sources
Interleukin-1 Receptor Antagonist
1993IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14.
openaire +2 more sources
Interleukin-1 Receptor Antagonist Expression in Sarcoidosis
American Review of Respiratory Disease, 1993Sarcoidosis is a systemic granulomatous disease with a marked propensity for involvement of the pulmonary parenchyma and thoracic lymphatic system. This granulomatous process is characterized by aggregations of mononuclear cells, multinucleated giant cells, and variable degrees of fibrosis.
M W, Rolfe +6 more
openaire +2 more sources
INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology
Annual Review of Immunology, 1998▪ Abstract The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18-kDa form ...
W P, Arend +3 more
openaire +2 more sources
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Nature, 1990Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations ...
C H, Hannum +9 more
openaire +2 more sources
Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1991The recent purification and characterization of an interleukin 1-receptor antagonist (IL-1ra) has provided an additional means of elucidating the mechanisms involved in the responses initiated by IL-1. Central administration of IL-1 to rabbits results in a characteristic febrile response and in increased non-rapid-eye-movement sleep (NREMS).
M R, Opp, J M, Krueger
openaire +2 more sources
Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.
Alimentary Pharmacology & Therapeutics, 1996Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
F, Cominelli, T T, Pizarro
openaire +2 more sources
Interleukin‐6 and interleukin‐1 receptor antagonist in acute stroke
Annals of Neurology, 1995AbstractElevated plasma levels of interleukin‐6 (IL‐6), a key regulator of the acute phase response that includes increased fibrinogen synthesis, have recently been detected in patients with acute stroke. Nevertheless, the role of the acute phase response in stroke has been controversial, with some studies suggesting that preexisting infection accounts
N B, Beamer +4 more
openaire +2 more sources
Interleukin-1 receptor antagonist
2000Interleukin-1 (IL-1) is a proinflammatory cytokine produced by a wide variety of cell types with an equally pleiotropic range of activities including the induction of fever, hypotension, adhesion molecule expression, neutrophilia, cartilage destruction, prostanoid production, and induction of the expression of a number of other cytokines. Two forms of
openaire +1 more source