Results 31 to 40 of about 158,089 (347)

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

open access: yes, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Abraham   +92 more
core   +7 more sources

Physiologic role of interleukin-1 receptor antagonist.

open access: yesArthritis research, 2000
Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both secreted and intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the arterial wall may not be adequate to effectively inhibit ...
William P. Arend, Cem Gabay
openaire   +3 more sources

Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis. [PDF]

open access: yes, 2017
BackgroundIntrauterine infection is a primary cause of preterm birth and fetal injury. The pro-inflammatory role of the fetal skin in the setting of intrauterine infection remains poorly characterized. Whether or not inflammation of the fetal skin occurs
Boonkasidecha, Suppawat   +4 more
core   +3 more sources

Interleukin-1 receptor antagonist (anakinra) for Schnitzler syndrome [PDF]

open access: yesJournal of Dermatological Treatment, 2016
Schnitzler syndrome is a rare autoinflammatory disease, which is defined by the presence of two major criteria: chronic urticaria and monoclonal immunoglobulin M (IgM) or immunoglobulin G gammopathy, in combination with at least two additional minor criteria: recurrent fever, leukocytosis and/or elevated C-reactive protein (CRP), objective signs of ...
Sönnichsen, Astrid   +11 more
openaire   +3 more sources

Association of the Interleukin-1 Receptor Antagonist Gene with Asthma [PDF]

open access: yesAmerican Journal of Respiratory and Critical Care Medicine, 2004
The interleukin-1 cluster on human chromosome 2q12-2q14 harbors various promising candidate genes for asthma and other inflammatory diseases. We conducted a systematic association study with single-nucleotide polymorphisms (SNPs) located in candidate genes situated in this cluster.
Gohlke H   +13 more
openaire   +4 more sources

Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1β and IL-1ra production in multiple sclerosis

open access: yesMediators of Inflammation, 2003
Background: Multiple sclerosis (MS) is an autoimmune disorder, with a considerable genetic influence on susceptibility and disease course. Cytokines play an important role in MS pathophysiology, and genes encoding various cytokines are logical candidates
Hans M. Schrijver   +4 more
doaj   +1 more source

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]

open access: yes, 2016
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core   +4 more sources

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist [PDF]

open access: yesNew England Journal of Medicine, 2009
Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations of IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement of skin and bone.We studied nine children from six families who had neonatal onset of ...
Deborah L. Stone   +41 more
openaire   +4 more sources

Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction [PDF]

open access: yes, 2015
Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the excessive generation or accumulation of free radicals or their oxidation products.
Cerretani D.   +6 more
core   +1 more source

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