Results 51 to 60 of about 78,472 (208)

Biological role of interleukin 1 receptor antagonist isoforms [PDF]

open access: yesAnnals of the Rheumatic Diseases, 2000
The interleukin 1 receptor antagonist (IL1Ra) family of molecules now includes one secreted isoform (sIL1Ra) and three intracellular isoforms (icIL1Ra1, 2, and 3). Extensive evidence indicates that the sole biological function of sIL1Ra seems to be to competitively inhibit IL1 binding to cell-surface receptors.
Carla J. Guthridge, William P. Arend
openaire   +3 more sources

The Clinical Significance of Interleukin-1 Receptor Antagonist +2018 Polymorphism in Rheumatoid Arthritis. [PDF]

open access: yesPLoS ONE, 2016
Interleukin-1 receptor antagonist (IL-1Ra) acts as an inhibitor of IL-1; which is one of the culprit cytokines in rheumatoid arthritis (RA). Although +2018 polymorphism of IL-1Ra has been implicated in the pathogenesis of RA, its importance remains ...
Endom Ismail   +4 more
doaj   +1 more source

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family. [PDF]

open access: yesJournal of Clinical Investigation, 1991
This review has summarized recent information derived from many laboratories on the discovery, characteristics, and properties of a new member of the IL-1 family, IL-1 receptor antagonist. In addition to information, an emphasis has been placed on unanswered questions and new concepts.
openaire   +3 more sources

Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

open access: yesJournal of Functional Foods, 2015
The immunomodulatory and epithelial barrier effects of cellulose as a dietary fibre were studied to analyse the potential for use in health promoting functional foods. Reporter assays demonstrated cellulose-mediated activation through TLR/MyD88 dependent-
Leonie M. Vogt   +4 more
doaj  

Interleukin-1B and Interleukin-1 Receptor Antagonist in Patients with Helicobacter pylori Associated Diseases [PDF]

open access: yesInternational Journal of Biomedicine, 2012
The ethnic people of the Republic of Khakassia (the Khakas) with ulcer disease show a significant T-cell activation and humoral immune response when compared with the Europoids.
Elizaveta S. Ageeva, PhD   +1 more
doaj  

A novel mutation of interleukin-1 receptor antagonist (IL1RN) in a DIRA patient from Turkey: Diagnosis and treatment

open access: yesThe Turkish Journal of Pediatrics, 2018
Autoinflammatory diseases can cause severe inflammation in bone and skin such as neonatal-onset multisystem inflammatory disease (NOMID), Majeed syndrome, interleukin-36 receptor antagonist deficiency (DITRA) and deficiency of interleukin-1 (IL-1 ...
Betül Sözeri   +4 more
doaj   +1 more source

MOLECULAR BIOLOGY ANALYSIS OF IL -1Β, IL -4, AND IL -1Β RA GENE POLYMORPHISMS IN ETHNIC BASHKIR PATIENTS WITH RHEUMATOID ARTHRITIS, LIVING IN C HELYABINSK REGION

open access: yesМедицинская иммунология, 2014
. Common polymorphisms of interleukin-1β, receptor antagonist interleukin-1, and interleukin-4 genes have been studied among the patients with rheumatoid arthritis of Bashkir origin, living in Chelyabinsk Region.
A. L. Burmistrova   +5 more
doaj   +1 more source

Cloning and Expression of Recombinant Human Interleukin 1 Receptor Antagonist in Escherichia Coli Strains, BL21 (DE3), Rosetta (DE3), and Origami (DE3)

open access: yesمجله دانشکده پزشکی اصفهان, 2019
Background: Recombinant human interleukin-1 receptor antagonist (IL-1RA) is a protein with 153 amino acids and molecular weight of 16.83 kDa. This drug protein is known as Anakinra, and has an effective application in the treatment of rheumatoid ...
Hanieh Fardgoli   +2 more
doaj   +1 more source

Mitoprotective effect of the receptor antagonist interleukin-1 in experimental cerebral stroke

open access: yesPatologìâ, 2012
Mitoprotective activity of the receptor antagonist of interleukin-1 ( RAIL-1, 7,5 mg/kg) comparing to Thiotriazoline (50 mg/kg) was studied on the model of experimental photoinduced cerebral thrombosis in rats.
E. V. Suprun
doaj   +1 more source

The safety of interleukin-1 receptor antagonist (anakinra) in the treatment of rheumatoid arthritis

open access: yesReumatismo, 2011
The safety profile of interleukin-1 receptor antagonist (anakinra) has been studied with randomised, placebo-controlled trials involving 2932 patients affected by rheumatoid arthritis.
L. Riente
doaj   +1 more source

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