Results 91 to 100 of about 628,146 (183)

Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrPC), Interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution [PDF]

, 2013
Lilian Calderón‐Garcidueñas, Janet V. Cross, Maricela Franco-Lira, Mariana Aragón-Flores, Michael Kavanaugh, Ricardo Torres‐Jardón, Chih‐Kai Chao, Charles Thompson, Jing Chang, Hongtu Zhu, Amedeo D’Angiulli   +10 more
openalex   +3 more sources

Immunological mechanisms and immunoregulatory strategies in intervertebral disc degeneration [PDF]

arXiv
Intervertebral discs are avascular and maintain immune privilege. However, during intervertebral disc degeneration (IDD), this barrier is disrupted, leading to extensive immune cell infiltration and localized inflammation. In degenerated discs, macrophages, T lymphocytes, neutrophils, and granulocytic myeloid-derived suppressor cells (G-MDSCs) are key ...
arxiv  

Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist. [PDF]

, 1993
Edouard Vannier, C A Dinarello
openalex   +1 more source

Predicting Novel Functional Roles of Designed Small Biomolecules: An ML Approach Utilizing PubChem Compound and Substance Identifiers (CID-SID ML model) [PDF]

arXiv
Significance and Object: The proposed methodology aims to provide time- and cost-effective approach for the early stage in drug discovery. The machine learning models developed in this study used only the identification numbers provided by PubChem.
arxiv  

Systemic Delivery of the Interleukin-1 Receptor Antagonist Protein Using a New Strategy of Direct Adenoviral-Mediated Gene Transfer to Skeletal Muscle Capillary Endothelium in the Isolated Rat Hindlimb [PDF]

, 1996
Theodore H. Welling, Beverly L. Davidson, Jennifer A. Zelenock, James C. Stanley, David Gordon, Blake J. Roessler, Louis M. Messina   +6 more
openalex   +1 more source

From atomic to global connectivity in the structure of the SARS-CoV2-Human ACE2 receptor complex [PDF]

arXiv
We investigate connectivity properties of the SARS-CoV2 spike protein-human ACE2-receptor complex employing a protein side chain-based network method that allows us to span a range from atomic to global protein scales. We analyze network topology in terms of clusters and cliques obtained from averaging over snapshots of MD simulations (from D.E.
arxiv  

Mitosis, Cytoskeleton Regulation, and Drug Resistance in Receptor Triple Negative Breast Cancer [PDF]

arXiv
During cell division, the receptor triple-negative MDA-MB-231 mitotic spindles are the largest in comparison to other BC cell lines. Many of the MDA-MB-231 spindles exhibit rapid lateral twisting during metaphase, which remains unaffected by knockdown of the oncogene Myc and treatment with inhibitors of the serine/threonine-protein kinase B-Raf and the
arxiv  

Muscle Protein Breakdown During Endotoxemia in Rats and After Treatment With Interleukin-1 Receptor Antagonist (IL-1 ra)

, 1992
O Zamir, Per-Olof Hasselgren, William J. O’Brien, Robert C. Thompson, Josef E. Fischer   +4 more
openalex   +2 more sources

Leptin activates the promoter of the interleukin-1 receptor antagonist through p42/44 mitogen-activated protein kinase and a composite nuclear factor kappaB/PU.1 binding site [PDF]

, 2003
Magali G. Dreyer, Cristiana E. Juge-Aubry, Cem Gabay, U. Lang, Françoise Rohner‐Jeanrenaud, Jean‐Michel Dayer, Christoph A. Meier   +6 more
openalex   +1 more source

Higher levels of IL-1ra, IL-6, IL-8, MCP-1, MIP-3α, MIP-3β, and fractalkine are associated with 90-day mortality in 132 non-immunomodulated hospitalized patients with COVID-19.

PLoS ONE
IntroductionImmune dysregulation with an excessive release of cytokines has been identified as a key driver in the development of severe COVID-19. The aim of this study was to evaluate the initial cytokine profile associated with 90-day mortality and ...
Liv Rabøl Andersen, Bettina Hindsberger, Simone Bastrup Israelsen, Lise Pedersen, Pal Bela Szecsi, Thomas Benfield   +5 more
doaj   +1 more source