Results 101 to 110 of about 628,146 (183)

Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis

Cell Reports, 2020
Summary: The Hippo/Yes-associated protein (YAP) pathway has pivotal roles in innate immune responses against pathogens in macrophages. However, the role of YAP in macrophages during atherosclerosis and its mechanism of YAP activation remain unknown. Here,
Mingming Liu, Meng Yan, Huizhen Lv, Biqing Wang, Xue Lv, Hang Zhang, Song Xiang, Jie Du, Tong Liu, Yikui Tian, Xu Zhang, Fangfang Zhou, Tao Cheng, Yi Zhu, Hongfeng Jiang, Yihai Cao, Ding Ai   +16 more
doaj  

Insights into new mechanosensitive behaviors of G protein-coupled receptors [PDF]

arXiv
G protein-coupled receptors (GPCRs) represent a diverse and vital family of membrane proteins that mediate intracellular signaling in response to extracellular stimuli, playing critical roles in physiology and disease. Traditionally recognized as chemical signal transducers, GPCRs have recently been implicated in mechanotransduction, the process of ...
arxiv  

Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with the relative change in body mass index between childhood and adulthood [PDF]

, 2007
Juha Saltevo, Mauno Vanhala, Hannu Kautiainen, Markku Laakso   +3 more
openalex   +1 more source

In Silico Approach for Pro-inflammatory Protein Interleukin 1β and Interleukin-1 Receptor Antagonist Protein Docking as Potential Therapy for COVID-19 Disease

, 2022
Wahyu Widowati, Kusworini Handono, Marlina Marlina, Ika Adhani Sholihah, Diana Krisanti Jasaputra, Teresa Liliana Wargasetia, Mawar Subangkit, Ahmad Faried, Ermi Girsang, I Nyoman Ehrich Lister, Chrismis Novalinda Ginting, Ita Margaretha Nainggolan, Rizal Rizal, Hanna Sari Widya Kusuma, Linda Chiuman   +14 more
openalex   +2 more sources

The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions

Cell Reports
Summary: Neuroinflammation is a well-established risk factor for various neurological disorders and cognitive decline. However, the precise molecular mechanisms linking inflammation with neuropsychiatric symptoms remain unclear.
Hyeji Jung, Byeongchan Kim, Gyubin Jang, Hyeonho Kim, Ae-Ree Lee, Sung-Hyun Yoon, Kyung-Seo Lee, Gaeun Hyun, Younghye Kim, Jaewon Ko, Je-Wook Yu, Ji Won Um   +11 more
doaj  

Deciphering the unique dynamic activation pathway in a G protein-coupled receptor enables unveiling biased signaling and identifying cryptic allosteric sites in conformational intermediates [PDF]

arXiv
Neurotensin receptor 1 (NTSR1), a member of the Class A G protein-coupled receptor superfamily, plays an important role in modulating dopaminergic neuronal activity and eliciting opioid-independent analgesia. Recent studies suggest that promoting \{beta}-arrestin-biased signaling in NTSR1 may diminish drugs of abuse, such as psychostimulants, thereby ...
arxiv  

Transcriptional responses consistent with perturbation in dermo-epidermal homeostasis in septic sole ulceration

Journal of Dairy Science
: The aim of this study was to evaluate transcriptional changes in the sole epidermis and dermis of bovine claws with septic sole ulceration of the lateral claw.
T.L. Reeder, D.S. Zarlenga, A.L. Ziegler, R.M. Dyer   +3 more
doaj  

Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors

Cell Communication and Signaling
Background Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated.
Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer   +8 more
doaj   +1 more source

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model [PDF]

, 2018
George Thom, Mei-Mei Tian, Jon P. Hatcher, Natalia Rodrigo Melero, Matthew Burrell, Ian Gurrell, Timothy Z. Vitalis, Thomas Abraham, Wilfred A. Jefferies, Carl I. Webster, Reinhard Gabathuler   +10 more
openalex   +1 more source

Cytokine-induced interleukin-1 receptor antagonist protein expression in genetically engineered equine mesenchymal stem cells for osteoarthritis treatment [PDF]

, 2018
Simone Gabner, Reinhard Ertl, Karsten Velde, Matthias Renner, Florien Jenner, Monika Egerbacher, Juraj Hlavatý   +6 more
openalex   +1 more source