Results 131 to 140 of about 628,146 (183)

Generation of a transgenic mouse with lung-specific overexpression of the human interleukin-1 receptor antagonist protein.

American Journal of Respiratory Cell and Molecular Biology, 1998
The purpose of the studies described here was to test the hypothesis that overexpression of the human interleukin-1 receptor antagonist (IL-1ra) in the distal airway epithelia of mice would result in amelioration of the inflammatory effects of IL-1alpha.
R. Wilmott, J. Kitzmiller, M. Fiedler, J. Stark   +3 more
semanticscholar   +3 more sources

Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β

European Journal of Immunology, 1991
AbstractTransforming growth factor‐β1 (TGF‐β1) mediates many immunosuppressive effects on immune cells and can inhibit the production of tumor necrosis factor and interleukin 1 (IL 1). However, TGF‐β1 can stimulate the production of IL6 and platelet‐derived growth factor, indicating that TGF‐β1 initiates complex effects on the production of cytokines ...
M. Turner, D. Chantry, P. Katsikis, A. Berge, F. Brennan, M. Feldmann   +5 more
semanticscholar   +4 more sources

Secondary structure and topology of interleukin-1 receptor antagonist protein determined by heteronuclear three-dimensional NMR spectroscopy.

Biochemistry, 1992
Interleukin-1 (IL-1) proteins, such as IL-1 beta, play a key role in immune and inflammatory responses. Interaction of these cytokines with the IL-1 receptor induces a variety of biological changes in neurologic, metabolic, hematologic, and ...
B. Stockman, T. Scahill, M. Roy, E. Ulrich, N. Strakalaitis, D. P. Brunner, A. Yem, M. R. Deibel   +7 more
semanticscholar   +4 more sources

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

Nature, 1990
A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced. A complementary DNA coding for IRAP was cloned and sequenced. The mature translation product of the cDNA has been expressed in Escherichia coli and was an active competitive inhibitor of the binding of ...
D. Carter, M. R. Deibel, C. J. Dunn, C. Tomich, A. Laborde, J. Slightom, A. E. Berger, Michael J. Bienkowski, F. Sun, R. McEwan, P. Harris, A. Yem, G. A. Waszak, J. Chosay, L. Sieu, M. Hardee, H. Zurcher-Neely, I. Reardon, R. Heinrikson, Scott E. Truesdell, J. Shelly, T. Eessalu, B. Taylor, D. Tracey   +23 more
semanticscholar   +4 more sources

Solution structure of human interleukin‐1 receptor antagonist protein [PDF]

FEBS Letters, 1994
Interleukin‐1 receptor antagonist protein (IRAP) is a naturally occurring inhibitor of the interleukin‐1 receptor. In contrast to IL‐1β IRAP binds to the IL‐1 receptor but does not elicit a physiological response. We have determined the solution structure of IRAP using NMR spectroscopy.
B. Stockman, T. Scahill, N. Strakalaitis, D. P. Brunner, A. Yem, M. R. Deibel   +5 more
semanticscholar   +4 more sources

Successful treatment of Erdheim-Chester disease by interleukin-1 receptor antagonist protein.

Joint Bone Spine, 2014
Erdheim-Chester disease is a rare non-langerhans systemic histiocytosis of unknown origin, associated with bone diseases and severe visceral complications. Therapies have been disappointing. A recombinant form of interleukin-1 receptor antagonist (anakinra) has been used in a few cases when usual treatment fails.
A. Courcoul, Emmanuelle Vignot, R. Chapurlat   +2 more
semanticscholar   +4 more sources

Distribution of interleukin 1 receptor antagonist protein (IRAP), interleukin 1 receptor, and interleukin 1α in normal and psoriatic skin. Decreased expression of IRAP in psoriatic lesional epidermis

British Journal of Dermatology, 1992
The distribution of interleukin 1 alpha (IL-1 alpha), type 1 interleukin 1 receptor (IL-1R), and the interleukin 1 receptor antagonist protein (IRAP), was investigated in biopsies of normal skin, and in uninvolved and lesional skin of patients with psoriasis, using specific monoclonal antibodies.
M. Kristensen, Bent Deleuran, D. Eedy, Marc Feldmann, S. Breathnach, F. Brennan   +5 more
semanticscholar   +5 more sources

Cytokine regulation of the interleukin‐1 receptor antagonist protein in U937 cells

European Journal of Immunology, 1993
AbstractA naturally occurring receptor‐level antagonist of interleukin‐1 (IRAPorIL‐1 ra) has recently been cloned. To determine what stimuli might regulate this inhibitor, cytokines were tested for their effects on the steady‐state level of IRAP mRNA in phorbol ester‐differentiated U937 cells.
A. E. Berger, D. Carter, S. Hankey, R. McEwan   +3 more
semanticscholar   +4 more sources

Treatment With an Interleukin-1 Receptor Antagonist Protein Prolongs Mouse Islet Allograft Survival

Diabetes, 1993
An interleukin-1 receptor antagonist protein was evaluated with regard to its efficacy in allogeneic and xenogeneic islet transplantation. Alloxan-induced diabetic C57BL/6 (H-2b) mice were transplanted under the kidney capsule with 500 C57BL/Ks (H-2d) mouse islets.
J. Sandberg, D. Eizirik, S. Sandler, D. Tracey, A. Andersson   +4 more
semanticscholar   +4 more sources

Cloning, heterologous expression and characterization of murine interleukin 1 receptor antagonist protein

European Journal of Immunology, 1991
AbstractA cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152‐residue protein that was 77% identical to human IL 1Ra.
M. E. Shuck, T. Eessalu, D. Tracey, M. Bienkowski   +3 more
semanticscholar   +4 more sources