Effects of interleukin-2 in immunostimulation and immunosuppression
Journal of Experimental Medicine, 2019 Distinctions in the nature and spatiotemporal expression of IL-2R subunits on conventional versus regulatory T cells are exploited to manipulate IL-2 immunomodulatory effects.
Jonathan G. Pol +4 more
semanticscholar +1 more source
Frontiers in Physiology, 2016 Increased pressure, associated with diving, can alter cell function through several mechanisms and has been shown to impact immune functions performed by peripheral blood mononuclear cells (PBMC) in humans.
Laura A Thompson, Tracy A. Romano
doaj +1 more source
Redistribution of DNA loop domains in human lymphocytes under blast transformation with interleukin 2 [PDF]
The Ukrainian Biochemical Journal, 2016 At higher order levels chromatin fibers in interphase nuclei are organized into loop domains. Gene regulatory elements (promoters and enhancers) are often located near the sites of loop attachments.
K. S. Afanasieva +4 more
doaj +1 more source
Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH.
Blood Advances, 2017 Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults.
A. Hayden +7 more
semanticscholar +1 more source
Production and characterisation of monoclonal antibodies specific for chicken interleukin-2 [PDF]
, 2001 Using genetic immunisation of mice, we produced antibodies against chicken interleukin-2 (ChIL-2), the first produced against a non-mammalian interleukin.
Hamblin, A, Kaiser, P, Rothwell, L
core +1 more source
Expression of inflammation-related genes is associated with adipose tissue location in horses [PDF]
, 2013 Background : In humans, adipose tissue (AT) originating from different depots shows varying gene expression profiles. In horses, the risk of certain metabolic disorders may also be influenced by the impact of specific AT depots.
Bruynsteen, Lien +6 more
core +2 more sources
Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFκB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA [PDF]
, 1999 Interleukin-1 receptor-associated kinase, IRAK, has been shown to activate NFκB in response to interleukin-1. We have explored the involvement of IRAK in regulation of the interleukin-2 gene in the murine thymoma cell line EL4.NOB-1 by examining its ...
Greene, Catherine, O’Neill, Luke
core +1 more source
Mathematical Models of the impact of IL2 modulation therapies on T cell dynamics
Frontiers in Immunology, 2013 Several reports in the literature have drawn a complex picture of the effect of treatments aiming to modulate IL2 activity in vivo. They seem to promote either immunity or tolerance, probably depending on the specific context, dose and timing of their ...
Kalet eLeon +2 more
doaj +1 more source
Interleukin-2 and leukemia [PDF]
Leukemia, 1998 Leukemia has been treated with chemotherapy for the past 40 years with only moderate success. A growing body of evidence suggests that by augmenting the immune system more effective results may be obtained. This is highlighted by T cell reinfusions resulting in durable remissions in patients with chronic myelogenous leukemia who have relapsed after an ...
M Goodman, Peter A. Cassileth, L Cabral
openaire +3 more sources
IL-4Rα Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis. [PDF]
, 2020 Dupilumab is a fully human antibody to interleukin-4 receptor α that improves the signs and symptoms of moderate to severe atopic dermatitis (AD). To determine the effects of dupilumab on Staphylococcus aureus colonization and microbial diversity on the ...
Ardeleanu, Marius +16 more
core +2 more sources