Results 21 to 30 of about 1,083,667 (362)

Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro

Bioengineering, 2020
High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration of high doses of IL2 can be toxic, causing capillary leakage syndrome and stimulating pro ...
Daria S. Chulpanova, Valeriya V. Solovyeva, Victoria James, Svetlana S. Arkhipova, Marina O. Gomzikova, Ekaterina E. Garanina, Elvira R. Akhmetzyanova, Leysan G. Tazetdinova, Svetlana F. Khaiboullina, Albert A. Rizvanov   +9 more
doaj   +1 more source

Phase II Trial of Maintenance Treatment With IL2 and Zoledronate in Multiple Myeloma After Bone Marrow Transplantation: Biological and Clinical Results

Frontiers in Immunology, 2021
BackgroundMaintenance treatment after autologous bone marrow transplantation in multiple myeloma improves the outcome of patients. We designed a phase II clinical trial to evaluate the treatment with IL2 and zoledronate after autologous bone marrow ...
Rita Fazzi, Iacopo Petrini, Nicola Giuliani, Riccardo Morganti, Giovanni Carulli, Benedetta Dalla Palma, Laura Notarfranchi, Sara Galimberti, Gabriele Buda   +8 more
doaj   +1 more source

Differences in Inflammatory Markers between Nulliparous Women Admitted to Hospitals in Preactive vs Active Labor [PDF]

, 2015
Objective To determine whether labor-associated inflammatory markers differ between low-risk, nulliparous women in preactive vs active labor at hospital admission and over time.
Arntzen, Bailit, Banchereau, Bennett, Bennett, Bollapragada, Caughey, Donna O. McCarthy, Golightly, Gotsch, Greig, Gucer, Hamilton, Hebisch, Holm, Holmes, Impey, Jane M. Lamp, Jarocki, Jeremy L. Neal, Kumar, Lin, Loraine T. Sinnott, Mikolajczyk, Mitchell, Nancy K. Lowe, Neal, Neal, Norman, Nowak, Nowak, Opsjln, Osman, Osmers, Papatheodorou, Ragusa, Rahnama, Roh, Romero, Sennstrom, Shannon L. Gillespie, Shynlova, Thomson, Torbe, Tribe, Vitoratos, Vitoratos, Young, Yuan, Zhang, Zhang   +50 more
core   +2 more sources

An optimized cultivation method for future in vivo application of γδ T cells

Frontiers in Immunology, 2023
γδ T cells, with their properties of both the innate and acquired immune systems, are suitable candidates for cellular immunotherapy in cancer. Because of their non-major histocompatibility complex (MHC) binding T cell receptor, allogenic transfer is ...
Anna Bold, Heike Gross, Elisabeth Holzmann, Stefan Knop, Timm Hoeres, Timm Hoeres, Martin Wilhelm   +6 more
doaj   +1 more source

Expression of inflammation-related genes is associated with adipose tissue location in horses [PDF]

, 2013
Background : In humans, adipose tissue (AT) originating from different depots shows varying gene expression profiles. In horses, the risk of certain metabolic disorders may also be influenced by the impact of specific AT depots.
Bruynsteen, Lien, Ducatelle, Richard, Erkens, Tim, Harris, Patricia, Hesta, Myriam, Janssens, Geert, Peelman, Luc   +6 more
core   +2 more sources

Abscopal responses in patients with metastatic melanoma involving skin and subcutaneous tissues treated with intralesional IL2 plus BCG

Frontiers in Oncology, 2023
Cutaneous melanoma is relatively common with increasing incidence and significant mortality. While the mainstay of therapy is surgical, patients with stage III and IV disease fare poorer than those with early-stage disease and often benefit from adjuvant
Dejan Vidovic, Lucy Kathryn Helyer, Sylvia Pasternak, Carman Anthony Giacomantonio   +3 more
doaj   +1 more source

Label-free, single molecule detection of cytokines using optical microcavities [PDF]

, 2007
Interleukin-2 (IL2) is a cytokine that regulates T-cell growth and is used in cancer therapies. By sensitizing a microcavity sensor surface with anti-IL2 and monitoring the resonant frequency, single molecules of IL2 can be ...
Armani, Andrea M., Fraser, Scott E., Vahala, Kerry J.   +2 more
core   +1 more source

Interleukin-2 and leukemia [PDF]

Leukemia, 1998
Leukemia has been treated with chemotherapy for the past 40 years with only moderate success. A growing body of evidence suggests that by augmenting the immune system more effective results may be obtained. This is highlighted by T cell reinfusions resulting in durable remissions in patients with chronic myelogenous leukemia who have relapsed after an ...
M Goodman, Peter A. Cassileth, L Cabral
openaire   +3 more sources

Interleukin-2 therapy in patients with HIV infection [PDF]

, 2009
BACKGROUND Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these increases is not known.
Aagaard, B., Abrams, D., Angus, B., Aragon, E., Arnaiz, J., Babiker, A., Borup, L., Clotet, B., Collins, G., Cooper, D. A., Cordwell, B., Darbyshire, J., Dodds, W., Dragsted, U., Emery, S., Fau, A., Fleck, S., Fox, L., Gey, D., Gordin, F., Grarup, J., Grijsen, M., Hengge, U., Herrero, P., Jansson, P., Jensen, B., Jensen, K., Juncher, H., Lane, H. C., Lange, J., Langebeek, N., Lopez, P., Losso, M. H., Lundgren, J., Lundgren, J. D., Lévy, Y., Matthews, C., Mitsuyasu, R., Mollerup, D., Neaton, J. D., Pearson, M., Phillips, A., Reilev, S., Reiss, P., Routy, J. P., Tambussi, G., Tillmann, K., van der Horst, C., Varea, S., Wentworth, D.   +49 more
core   +5 more sources

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

Molecular Therapy: Oncolytics, 2017
Adoptive cell therapy holds much promise in the treatment of cancer but results in solid tumors have been modest. The notable exception is tumor-infiltrating lymphocyte (TIL) therapy of melanoma, but this approach only works with high-dose ...
Riikka Havunen, Mikko Siurala, Suvi Sorsa, Susanna Grönberg-Vähä-Koskela, Michael Behr, Siri Tähtinen, João Manuel Santos, Pauliina Karell, Juuso Rusanen, Dirk M. Nettelbeck, Anja Ehrhardt, Anna Kanerva, Akseli Hemminki   +12 more
doaj   +1 more source