Results 31 to 40 of about 23,313,489 (418)
The Interleukin 2 Receptor [PDF]
Annual Review of Cell and Developmental Biology, 1988 Publisher Summary Although it was assumed initially that the various activities found in conditioned media were solely produced by lymphocytes, this idea was broadened subsequently to allow for activities that are produced by nonlymphoid cells, and the term cytokine is now sometimes used.
openaire +3 more sources
Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy [PDF]
, 2017 The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and ...
Fremont, Daved H +6 more
core +2 more sources
OncoImmunology, 2019 Immunotherapy with the anti-GD2 antibody (Ab) ch14.18/CHO in combination with interleukin 2 (IL-2) has improved survival of high-risk neuroblastoma (NB) patients.
Sascha Troschke-Meurer +8 more
doaj +1 more source
Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine IL-6 are related to synovitis and pain in end-stage knee osteoarthritis patients [PDF]
Pain. 2017 Jul;158(7):1254-1263, 2019 Little is known about local and systemic biomarkers in relation to synovitis and pain in end-stage osteoarthritis (OA) patients. We investigated the associations between the novel extracellular matrix biomarker, C1M, and local and systemic interleukin 6 (IL-6) with synovitis and pain.
arxiv +1 more source
Label-free, single molecule detection of cytokines using optical microcavities [PDF]
, 2007 Interleukin-2 (IL2) is a cytokine that regulates T-cell growth and is used in cancer therapies. By sensitizing a microcavity sensor surface with anti-IL2 and monitoring the resonant frequency, single molecules of IL2 can be ...
Armani, Andrea M. +2 more
core +1 more source
Bioengineering, 2020 High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration of high doses of IL2 can be toxic, causing capillary leakage syndrome and stimulating pro ...
Daria S. Chulpanova +9 more
doaj +1 more source
Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension [PDF]
, 2010 BACKGROUND: Inflammation is a feature of pulmonary arterial hypertension (PAH), and increased circulating levels of cytokines are reported in patients with PAH.
Barker, Lucy +13 more
core +1 more source
Frontiers in Pediatrics, 2020 Patients with high-risk neuroblastoma treated with continuous long-term infusion of anti-GD2 antibody dinutuximab beta (DB) in combination with IL-2 show an acceptable safety profile. Here, we compared treatment tolerance with and without IL-2.
Filiz Cicek +7 more
doaj +1 more source
Evaluating the Use of Generalized Dynamic Weighted Ordinary Least Squares for Individualized HIV Treatment Strategies [PDF]
arXiv, 2021 Dynamic treatment regimes (DTR) are a statistical paradigm in precision medicine which aim to optimize patient outcomes by individualizing treatments. At its simplest, a DTR may require only a single decision to be made; this special case is called an individualized treatment rule (ITR) and is often used to maximize short-term rewards.
arxiv
Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.
New England Journal of Medicine, 2010 BACKGROUND Preclinical and preliminary clinical data indicate that ch14.18, a monoclonal antibody against the tumor-associated disialoganglioside GD2, has activity against neuroblastoma and that such activity is enhanced when ch14.18 is combined with ...
A. Yu +19 more
semanticscholar +1 more source