Results 31 to 40 of about 22,989,400 (391)

Administration of fusion cytokines induces tumor regression and systemic antitumor immunity

MedComm, 2021
It is difficult to improve the curative effects of cancer immunotherapy on solid tumors. Cytokines, as powerful immune regulators, show potential in activating host antitumor immunity.
Jinyu Zhang, Xuan Zhao
doaj   +1 more source

Interleukin-2 therapy in patients with HIV infection [PDF]

, 2009
BACKGROUND Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these increases is not known.
Aagaard, B., Abrams, D., Angus, B., Aragon, E., Arnaiz, J., Babiker, A., Borup, L., Clotet, B., Collins, G., Cooper, D. A., Cordwell, B., Darbyshire, J., Dodds, W., Dragsted, U., Emery, S., Fau, A., Fleck, S., Fox, L., Gey, D., Gordin, F., Grarup, J., Grijsen, M., Hengge, U., Herrero, P., Jansson, P., Jensen, B., Jensen, K., Juncher, H., Lane, H. C., Lange, J., Langebeek, N., Lopez, P., Losso, M. H., Lundgren, J., Lundgren, J. D., Lévy, Y., Matthews, C., Mitsuyasu, R., Mollerup, D., Neaton, J. D., Pearson, M., Phillips, A., Reilev, S., Reiss, P., Routy, J. P., Tambussi, G., Tillmann, K., van der Horst, C., Varea, S., Wentworth, D.   +49 more
core   +5 more sources

Autologous cancer cell vaccination, adoptive T‐cell transfer, and interleukin‐2 administration results in long‐term survival for companion dogs with osteosarcoma

Journal of Veterinary Internal Medicine, 2020
Background Osteosarcoma (OSA) in dogs is an aggressive bone tumor with frequent chemotherapy failure and translational relevance for human health. Hypothesis/Objectives We hypothesized that dogs with OSA could be treated safely by ex vivo activated T ...
Brian K. Flesner, Gary W. Wood, Pamela Gayheart‐Walsten, F. Lynn Sonderegger, Carolyn J. Henry, Deborah J. Tate, Sandra M. Bechtel, Lindsay L. Donnelly, Gayle C. Johnson, Dae Young Kim, Tammie A. Wahaus, Jeffrey N. Bryan, Noe Reyes   +12 more
doaj   +1 more source

Spontaneous Expression of Interleukin-2 In Vivo in Specific Tissues of Young Mice [PDF]

, 1998
In situ hybridization and immunohistochemistry were used to determine the spectrum of tissues in which interleukin-2 (IL-2) mRNA and protein are found in healthy, normal young mice.
Rothenberg, Ellen V., Yang-Snyder, Julia A.   +1 more
core   +4 more sources

Placental-mediated increased cytokine response to lipopolysaccharides: a potential mechanism for enhanced inflammation susceptibility of the preterm fetus. [PDF]

, 2012
BackgroundCerebral palsy is a nonprogressive motor impairment syndrome that has no effective cure. The etiology of most cases of cerebral palsy remains unknown; however, recent epidemiologic data have demonstrated an association between fetal neurologic ...
Belkacemi, Louiza, Beloosesky, Ron, Boles, Julie L, Desai, Mina, Ross, Michael G   +4 more
core   +1 more source

Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]

, 2008
Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C., Ceuppens, J., De Buck, F., Delforge, M., Kasran, A., Meyns, B., Sergeant, P., Van Duppen, V., Van Hemelrijck, J., Wouters, Patrick   +9 more
core   +2 more sources

Production and characterisation of monoclonal antibodies specific for chicken interleukin-2 [PDF]

, 2001
Using genetic immunisation of mice, we produced antibodies against chicken interleukin-2 (ChIL-2), the first produced against a non-mammalian interleukin.
Hamblin, A, Kaiser, P, Rothwell, L
core   +1 more source

Recovery of T‐cell function in healthy dogs following cessation of oral cyclosporine administration

Veterinary Medicine and Science, 2020
Cyclosporine is a potent immunosuppressive agent used to treat immune‐mediated disorders in dogs. Secondary infections sometimes necessitate withdrawal of cyclosporine, but it is not known how long it takes for the immune system to recover after ...
Lakshmi Narayanan, Charlee Mulligan, Lisa Durso, Brittany Thames, John Thomason, Claire Fellman, Andrew Mackin, Robert Wills, Todd Archer   +8 more
doaj   +1 more source

Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.

New England Journal of Medicine, 2010
BACKGROUND Preclinical and preliminary clinical data indicate that ch14.18, a monoclonal antibody against the tumor-associated disialoganglioside GD2, has activity against neuroblastoma and that such activity is enhanced when ch14.18 is combined with ...
A. Yu, A. Gilman, M. Ozkaynak, W. London, S. Kreissman, Helen X Chen, Malcolm A. Smith, B. Anderson, J. Villablanca, K. Matthay, H. Shimada, S. Grupp, R. Seeger, C. Reynolds, A. Buxton, R. Reisfeld, S. Gillies, S. Cohn, J. Maris, P. Sondel   +19 more
semanticscholar   +1 more source

Redistribution of DNA loop domains in human lymphocytes under blast transformation with interleukin 2 [PDF]

The Ukrainian Biochemical Journal, 2016
At higher order levels chromatin fibers in interphase nuclei are organized into loop domains. Gene regulatory elements (promoters and enhancers) are often located near the sites of loop attachments.
K. S. Afanasieva, M. I. Chopei, A. V. Lozovik, S. R. Rushkovsky, A. V. Sivolob   +4 more
doaj   +1 more source