The Interleukin 2 Receptor [PDF]
Annual Review of Cell and Developmental Biology, 1988 Publisher Summary Although it was assumed initially that the various activities found in conditioned media were solely produced by lymphocytes, this idea was broadened subsequently to allow for activities that are produced by nonlymphoid cells, and the term cytokine is now sometimes used.
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Production and characterisation of monoclonal antibodies specific for chicken interleukin-2 [PDF]
, 2001 Using genetic immunisation of mice, we produced antibodies against chicken interleukin-2 (ChIL-2), the first produced against a non-mammalian interleukin.
Hamblin, A, Kaiser, P, Rothwell, L
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Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. [PDF]
, 2012 BackgroundIschemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation.
Dodd-o, Jeffrey M +5 more
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The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]
, 2008 The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda +61 more
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Comparison of LPS-stimulated release of cytokines in punch versus transwell tissue culture systems of human gestational membranes [PDF]
, 2010 Background Cytokine signaling within the amnionic, chorionic and decidual extraplacental gestational membranes plays an important role in membrane rupture and the timing of birth.
Loch-Caruso, Rita, Miller, Mark F.
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The hepatic sympathetic nerve plays a critical role in preventing Fas induced liver injury in mice [PDF]
, 2005 Background: Although previous studies have shown that the hepatic sympathetic nerve controls various physiological functions in the liver, the role of this nerve in liver injury has yet to be clarified.Aims: The purpose of this study was to elucidate the
Chida, Y, Kubo, C, Sudo, N, Takaki, A
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Spontaneous Expression of Interleukin-2 In Vivo in Specific Tissues of Young Mice [PDF]
, 1998 In situ hybridization and immunohistochemistry were used to determine the spectrum of tissues in which interleukin-2 (IL-2) mRNA and protein are found in healthy, normal young mice.
Rothenberg, Ellen V. +1 more
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A modified assay for measuring thymocyte co-stimulatory activity
Memorias do Instituto Oswaldo Cruz, 1993 The observation that murine thymocytes increase their proliferation to interleukin 1 (IL-1) in the presence of phytohemagglutinin (PHA) when pre-incubated with interleukin 2 (IL-2) allowed the introduction of a modified assay for the measurement of IL-1 ...
Sergio R. Dalmau +2 more
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Journal of Veterinary Internal Medicine, 2020 Background Dogs are often adminstered >1 immunosuppressive medication when treating immune‐mediated diseases, and determining whether these different medications affect IL‐2 expression would be useful when performing pharmacodynamic monitoring during ...
Todd M. Archer +10 more
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The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis
Journal of Translational Autoimmunity, 2021 The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R)
Daphne Peerlings +2 more
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