Results 81 to 90 of about 23,313,489 (418)
Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures [PDF]
, 2012 The crystal structure of the interleukin-2 tyrosine kinase Src homology domain (Itk SH2) is described and it is found that unlike in studies of this domain using NMR spectroscopy, cis-trans-prolyl isomerization is not readily detected in the crystal ...
Andreotti, Amy +7 more
core +3 more sources
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1992 Parasites may employ particular strategies of eluding an immune response by taking advantage of those mechanisms that normally guarantee immunological self-tolerance. Much in the way as it occurs during the establishment of self-tolerance, live pathogens
Owen Williams +3 more
doaj +1 more source
Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
Frontiers in Medicine, 2021 Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease.
Henrique Pott-Junior +7 more
doaj +1 more source
Expression of interleukin 2 receptors on activated human B cells. [PDF]
, 1984 Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated B cells display receptors for IL-2.
Bongiovanni, KF +8 more
core
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Proinflammatory Cytokines Dynamics at Operation Site and Serum After Breast Surgery
Archives of Clinical and Experimental Surgery, 2013 Objectives: Mastectomy and axillary dissection (AD) provide a good model to study local inflammatory response and wound healing after surgery. The involved factors include pro-inflammatory cytokines. This prospective study investigated kinetic changes of
Zuhoor K. Al-Gaithy
doaj +1 more source
In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection [PDF]
, 1987 We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that in vivo application of recombinant human IL-2 (rhIL-2) can enhance the antiviral effect of a limited number of CD8+T lymphocytes, not only in ...
Koszinowski, Ulrich H. +2 more
core +3 more sources
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma.
New England Journal of Medicine, 2011 BACKGROUND Stimulating an immune response against cancer with the use of vaccines remains a challenge. We hypothesized that combining a melanoma vaccine with interleukin-2, an immune activating agent, could improve outcomes.
D. Schwartzentruber +25 more
semanticscholar +1 more source