Results 61 to 70 of about 98,375,777 (262)

Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2

OncoImmunology, 2019
Immunotherapy with the anti-GD2 antibody (Ab) ch14.18/CHO in combination with interleukin 2 (IL-2) has improved survival of high-risk neuroblastoma (NB) patients.
Sascha Troschke-Meurer, Nikolai Siebert, Madlen Marx, Maxi Zumpe, Karoline Ehlert, Oliver Mutschlechner, Hans Loibner, Ruth Ladenstein, Holger N. Lode   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis.

, 2002
Host genetic factors are major determinants of susceptibility to tuberculosis, and an understanding of the molecular basis of this observation has major implications for the development of novel therapies and vaccines.
Howson, Joanna M M, Awomoyi, Agnes A, Agnes A Awomoyi (16176401), Arnaud Marchant (70401), Joanna M M Howson (3809950), Newport, M J, Keith P W J McAdam (16181906), Melanie Newport (4461202), McAdam, K P, Marchant, Arnaud, Blackwell, Jenefer M, Jenefer M Blackwell (10682454)   +11 more
core   +1 more source

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review [PDF]

, 2008
Background The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations.
Kaptoge Stephen, Kaptoge, S., Lennon, L., Danesh, J, Lucy Lennon, Gudnason, Vilmundur, Stephen Kaptoge, Higgins Julian P. T, Wensley, F, Mann, Andrea G, Rumley, A., Sarwar, N, Wood, A, Ann Rumley, Vilmundur Gudnason, Danesh, J., Angleman, Sara B, Wood, A., Gudnason, V., Danesh John, Kaptoge, S, Wensley Frances, Wood, Angela, Lowe, G.D., John Danesh, Eiriksdottir, Gudny, Rumley, Ann, Angleman Sara B, Wensley, Frances, Gudnason Vilmundur, Sara B Angleman, Whincup Peter H, Kaptoge, Stephen, Gordon D O Lowe, Lennon Lucy, Sarwar, Nadeem, Higgins, JPT, Lennon, L, Higgins, J.P.T., Andrea G Mann, Peter H Whincup, Mann, AG, Lowe, GDO, Whincup, PH, Mann Andrea G, Whincup, P.H., Julian P T Higgins, Higgins, Julian PT, Lowe, Gordon DO, Angleman, S.B., Wensley, F., Sarwar, N., Mann, A.G., Eiriksdottir, G, Higgins, JP, Danesh, John, Sarwar Nadeem, Gudnason, V, Angleman, SB, Eiriksdottir, G., Lowe Gordon D. O, Angela Wood, Frances Wensley, Lowe, GD, Whincup, Peter H, Nadeem Sarwar, Eiriksdottir Gudny, Gudny Eiriksdottir, Wood Angela, Lennon, Lucy, Rumley Ann, Rumley, A   +71 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

The combination of IL-2 nanoparticles and Palbociclib enhances the anti-tumor immune response for colon cancer therapy

Frontiers in Immunology
Immunotherapy of tumors plays a pivotal role in the current treatment of cancer. While interleukin 2 (IL-2) demonstrated its efficacy as an immunotherapeutic drug in the early days, its short blood circulation time poses challenges in maintaining ...
Di Wang, Xiaoshuang Wang, Yingyu Zhang, Le Yu, Jing An, Xiaodong Wang, Yue Huang, Xuemei Han   +7 more
doaj   +1 more source

In Vitro Interleukin-1 and 2 Production and Interleukin 2 Receptor Expression in the Rhesus Monkey [PDF]

, 1996
Anti-human monoclonal antibodies were used to detect and quantify interleukins-1 and 2 and interleukin-2 receptor expression in peripheral blood mononuclear cells from a rhesus monkey. Interleukin-1 production could be induced by phorbol esters (PMA) and
Sonnenfeld, Gerald, Schaffar, Laurance, Schmitt, Didier A., Andre, Eric, Tkaczuk, Jean, Husson, David   +5 more
core  

Begg’s funnel plot evaluated the effect of anti-interleukin-5 on FEV₁.

, 2016
Begg’s funnel plot evaluated the effect of anti-interleukin-5 on FEV1.
Ting Liu (45625), Fa-Ping Wang (3358667), Hui Mao (115181), Zhu Lan (3358673), Su-Yun Li (3358670)   +4 more
core   +1 more source

Mathematical modeling of interleukin-27 induction of anti-tumor T cells response. [PDF]

, 2014
Interleukin-12 is a pro-inflammatory cytokine which promotes Th1 and cytotoxic T lymphocyte activities, such as Interferon-[Formula: see text] secretion. For this reason Interleukin-12 could be a powerful therapeutic agent for cancer treatment.
Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman, Kang-Ling Liao, Avner Friedman, Xue-Feng Bai (333686), Bai Xue-Feng, Liao Kang-Ling, Xue-Feng Bai, Friedman Avner, Kang-Ling Liao (535938), Avner Friedman (54903)   +9 more
core   +1 more source