Results 61 to 70 of about 541,619 (302)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

IL-23 (Interleukin-23)-Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke. [PDF]

, 2018
Inflammatory mechanisms can exacerbate ischemic tissue damage and worsen clinical outcome in patients with stroke. Both ?? and ?? T cells are established mediators of tissue damage in stroke, and the role of dendritic cells (DCs) in inducing the early ...
Gelderblom, Mathias;Gallizioli, Mattia;Ludewig, Peter;Thom, Vivien;Arunachalam, Priyadharshini;Rissiek, Björn;Bernreuther, Christian;Glatzel, Markus;Korn, Thomas;Arumugam, Thiruma Valavan;Sedlacik, Jan;Gerloff, Christian;Tolosa, Eva;Planas, Anna M;Magnus, Tim
core   +2 more sources

Evaluation of Interleukin-17 and Interleukin-23 in Pterygium: Immunohistochemistry Study

Asia-Pacific Journal of Ophthalmology, 2017
To compare the interleukin-17 (IL-17) and interleukin-23 (IL-23) positive cell counts between pterygium and normal conjunctiva.A case-control study.This study received ethical approval (NMRR Research ID 23957) and informed consent was obtained from all participants.
Kiew Ing, Tiong, Aida Zairani, Mohd Zahidin, S Kala A/P, Sumugam, Joseph, Uchang, Hazlita Dato', Mohd Isa   +4 more
openaire   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

New therapeutic targets for the management of moderate-severe psoriasis

Journal of IMIDs, 2022
The field of moderate-severe psoriasis is experiencing a real therapeutic revolution in recent years with the appearance of new molecules that present more selective pathophysiological targets.
José C. Ruiz-Carrascosa, Angela Ayén-Rodriguez, José M. Llamas-Molina, Ricardo Ruiz-Villaverde   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Uncovering how interleukin-5 and interleukin-23 shape human immune defense against Salmonella enterica Typhi

Journal of Microbiology and Infectious Diseases
Background: Salmonella enterica serotype Typhi remains a major global health concern, particularly in regions with limited resources. Interleukins such as interleukin-5 and interleukin-23 are thought to play pivotal roles in shaping the host's ...
Ruaa Kareem Surhan, Aqeel A. Al-Sadawi, Ali Reyadh Medhat, Ahmed Al Obaidi   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Interleukin-23 and interleukin-17: Importance in pathogenesis and therapy of psoriasis

Dermatology Online Journal, 2012
Emerging data in mice and humans reveals a critical contribution of Th17-associated cytokines, particularly interleukin-(IL)-23 and IL-17, in the pathogenesis of psoriasis. The IL-23/Th17 pathway is a therapeutic target for biologic agents and systemic therapies in psoriasis treatment.
Mudigonda, Parvathi, Mudigonda, Tejaswi, Feneran, Ashley N, Alamdari, Habibollah S, Sandoval, Laura, Feldman, Steven R   +5 more
openaire   +4 more sources