Results 11 to 20 of about 728,843 (299)

Interleukin‐33 in allergy [PDF]

Allergy, 2012
AbstractInterleukin‐33 (IL‐33) is a member of the IL‐1 cytokine family, which includes IL‐1 and IL‐18, and is considered to be important for host defense against nematodes by inducing Th2 cytokine production via the IL‐33 receptor. IL‐33 receptor is a heterodimer of IL‐1 receptor‐like 1 (IL‐1RL1; also called ST2, T1, Der4, and fit‐1) and IL‐1 receptor ...
Tatsukuni, Ohno, Hideaki, Morita, Ken, Arae, Kenji, Matsumoto, Susumu, Nakae   +4 more
openaire   +2 more sources

Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments

Journal of Neuroinflammation, 2020
Background Interleukin (IL)-33 is expressed in a healthy brain and plays a pivotal role in several neuropathologies, as protective or contributing to the development of cerebral diseases associated with cognitive impairments.
Flora Reverchon, Vidian de Concini, Vanessa Larrigaldie, Sulayman Benmerzoug, Sylvain Briault, Dieudonnée Togbé, Bernhard Ryffel, Valérie F. J. Quesniaux, Arnaud Menuet   +8 more
doaj   +1 more source

Interleukin-33 in the human placenta [PDF]

The Journal of Maternal-Fetal & Neonatal Medicine, 2012
Interleukin-33 (IL-33) is the newest member of the IL-1 cytokine family, a group of key regulators of inflammation. The purpose of this study was to determine whether IL-33 is expressed in the human placenta and to investigate its expression in the context of acute and chronic chorioamnionitis.Placental tissues were obtained from five groups of ...
Vanessa, Topping, Roberto, Romero, Nandor Gabor, Than, Adi L, Tarca, Zhonghui, Xu, Sun Young, Kim, Bing, Wang, Lami, Yeo, Chong Jai, Kim, Sonia S, Hassan, Jung-Sun, Kim   +10 more
openaire   +2 more sources

Interleukin-33 modulates inflammation in endometriosis [PDF]

Scientific Reports, 2017
AbstractEndometriosis is a debilitating condition that is categorized by the abnormal growth of endometrial tissue outside the uterus. Although the pathogenesis of this disease remains unknown, it is well established that endometriosis patients exhibit immune dysfunction.
Miller, Jessica E., Monsanto, Stephany P., Ahn, Soo Hyun, Khalaj, Kasra, Fazleabas, Asgerally T., Young, Steven L., Lessey, Bruce A., Koti, Madhuri, Tayade, Chandrakant   +8 more
openaire   +2 more sources

Interleukin 33: a switch-hitting cytokine [PDF]

Current Opinion in Immunology, 2014
For many years IL-33 has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Interestingly, IL-33 has now emerged as a cytokine with a plethora of pleiotropic properties. Depending on the immune cells targeted by IL-33, it is reported to not only promote Th2 immunity, but also to induce T helper type 1 (Th1 ...
Daniel O, Villarreal, David B, Weiner
openaire   +2 more sources

Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins [PDF]

, 1993
The human serine proteases granzymes A and B are expressed in cytotoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. Recombinant granzyme A and granzyme B proteins were produced in bacteria, purified and then used to raise ...
Borst, Jannie, Brakenhoff, Just P.J., Hack, C. Erik, Kamp, Angela M., Kummer, J. Alain, Radosevic, K., Radosevic, Katarina, van Katwijk, Marcel, van Leeuwen, Anne Marie, Verweij, Cornelis L.   +9 more
core   +7 more sources

Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system [PDF]

, 2016
Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer’s disease.
Allan, Debbie, Barnett, Susan C., Elliott, Christina, Fairlie-Clarke, Karen J., Jiang, Hui-Rong, Lassmann, Hans, Linnington, Christopher, Schuh, Cornelia   +7 more
core   +2 more sources

Identification of Constitutively Active Interleukin 33 (IL-33) Splice Variant [PDF]

Journal of Biological Chemistry, 2011
IL-33/IL-1F11 is a new member of the IL-1 family ligand and provokes T helper-type immune responses. IL-33 is the ligand of ST2 and IL-1 receptor accessory protein (IL-1RAcP) that triggers nuclear factor-κ light chain enhancer of activated B cells (NF-κB) and MAPK signaling.
Jaewoo, Hong, Suyoung, Bae, Hyunjhung, Jhun, Siyoung, Lee, Jida, Choi, Taebong, Kang, Areum, Kwak, Kwangwon, Hong, Eunsom, Kim, Seunghyun, Jo, Soohyun, Kim   +10 more
openaire   +2 more sources

Comparison of Interleukin-33 serum levels in asthmatic patients with a control group and relation with the severity of the disease

International Journal of Preventive Medicine, 2017
Background: The relation between interleukin-33 (IL-33) and asthma is not precisely known yet. The present study set to compare the serum level of IL-33 in patients with asthma and controls and study the relation with the severity of disease.
Tooba Momen, Hamid Ahanchian, Mohsen Reisi, Seyedeh Azra Shamsdin, Armindokht Shahsanai, Majid Keivanfar   +5 more
doaj   +1 more source

Changes of Interleukins in Patients with Nosocomial Pneumonia Against a Background of Traumatic Brain Injury: Role in the Diagnosis and Monitoring of Disease [PDF]

, 2017
Introduction. Nosocomial pneumonia (NP) is the second leading frequency and mortality among nosocomial infections. NP is a frequent complication of severe traumatic brain injury (TBI).
Ilchenko, A. (Anastasiia)
core   +2 more sources