Results 21 to 30 of about 242,578 (255)

Response to Treatment with an Anti-Interleukin-6 Receptor Antibody (Tocilizumab) in a Patient with Hemophagocytic Syndrome Secondary to Immune Checkpoint Inhibitors [PDF]

Case Reports in Oncological Medicine, 2021
Background. Immunotherapy represents one of the fundamental treatments in the management of some types of cancer, especially malignant melanoma. Toxicity derived from increased immune system activity can manifest in multiple organs and systems.
Alejandro Olivares-Hernández, Luis Figuero-Pérez, María A. Amores Martín, Lorena Bellido Hernández, Laura Mezquita, María del Rosario Vidal Tocino, Félix López Cadenas, Felipe Gómez-Caminero López, Roberto A. Escala-Cornejo, Juan Jesús Cruz Hernández   +9 more
openaire   +3 more sources

Psoriatic arthritis successfully treated with second-line anti-interleukin-6 treatment: a case report and review of the literature 

Journal of Medical Case Reports, 2022
Background Psoriatic arthritis treatment with antitumor necrosis factor has been shown to reduce disease activity. Nonetheless, more than 30% of patients do not achieve a sufficient response to tumor necrosis factor blockers.
Tatsuhiko Kutsuna, Kazunori Hino, Hitoshi Hasegawa, Kunihiko Watamori, Teruki Kidani, Hiroshi Imai, Hiromasa Miura   +6 more
doaj   +1 more source

Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes

Journal of Pharmacological Sciences, 2006
UTP causes interleukin (IL)-6 production via mRNA expression through P2Y2/P2Y4 receptors in human HaCaT keratinocytes. In the present study, we analyzed the mechanism of UTP-induced IL-6 production in these cells.
Daisaku Kobayashi, Satoko Ohkubo, Norimichi Nakahata   +2 more
doaj   +1 more source

A GLP-1 Analog Liraglutide Reduces Intimal Hyperplasia After Coronary Stent Implantation via Regulation of Glycemic Variability and NLRP3 Inflammasome/IL-10 Signaling in Diabetic Swine

Frontiers in Pharmacology, 2020
ObjectiveThis study aimed to explore whether treatment with the glucagon-like peptide-1 (GLP-1) analog liraglutide reduces intimal hyperplasia after coronary stent implantation via regulation of glycemic variability, the NLRP3 inflammasome, and IL-10 in ...
Jinggang Xia, Qinxue Li, Yayun Liu, Quanxin Ren, Jinhuan Gao, Yi Tian, Jubo Li, Baojie Zhang, Haichen Sun, Shuang Liu   +9 more
doaj   +1 more source

Effect of IRAK1/4 inhibitor on IL-1β, IL-6, INF-γ and TNF-α expression in breast cancer cells of several lines [PDF]

The Ukrainian Biochemical Journal, 2021
Recent studies have shown that inflammation mediated via interleukin-1 receptor-associated kinases (IRAKs) is associated with cancer cells drug resistance.
M. Rezaei, B. Shahouzehi, S. Rahemi, H. Fallah, M. Salarkarimi   +4 more
doaj   +1 more source

Two Biosensors for the Determination of Interleukin-6 in Blood Plasma by Array SPRi

Biosensors, 2022
Interleukin-6 (IL-6) is a biomarker of inflammation, the advanced stage of COVID-19, and several cancers, including ovarian cancer. Two biosensors for the determination of IL-6 in blood plasma by array SPRi have been developed.
Beata Szymanska, Zenon Lukaszewski, Lukasz Oldak, Beata Zelazowska-Rutkowska, Kinga Hermanowicz-Szamatowicz, Ewa Gorodkiewicz   +5 more
doaj   +1 more source

Practical issues in the use of levilimab, a novel interleukin-6 receptor inhibitor, in patients with rheumatoid arthritis

Clinical pharmacology and therapy, 2022
Levilimab is a monoclonal antibody targeting interleukin-6 receptors and having a potent anti-inflammatory activity. Efficacy and safety of levilimab for treatment of rheumatoid arthritis were established in multicenter, double blind, placebo-controlled clinical trials AURORA and SOLAR.
S. Moiseev, V. Logina, M. Litvinova, T. Shevtsova, N. Nosova, E. Kuznetsova, P. Novikov   +6 more
openaire   +1 more source

Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts. [PDF]

PLoS ONE, 2013
BACKGROUND: Leptin, an adipocyte-secreted hormone that centrally regulates weight control, may exert proinflammatory effects in the joint, depending on the immune response.
Wei-Hung Yang, Shan-Chi Liu, Chun-Hao Tsai, Yi-Chin Fong, Shoou-Jyi Wang, Yung-Sen Chang, Chih-Hsin Tang   +6 more
doaj   +1 more source

Heterotrimeric G Protein Gα13-Induced Induction of Cytokine mRNAs Through Two Distinct Pathways in Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2006
.: Overexpression of constitutively active (CA)-Gα13 significantly increased the expression of interleukin (IL)-1β and IL-6 mRNAs and proteins in rat cardiac fibroblasts.
Nagamatsu Yuichi, Nishida Motohiro, Onohara Naoya, Fukutomi Masashi, Maruyama Yoshiko, Kobayashi Hiroyuki, Sato Yoji, Kurose Hitoshi   +7 more
doaj   +1 more source

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein

Biomedicines, 2021
Background: Vascular endothelial cells activation and dysfunction mediate inflammation and abnormal coagulation in COVID-19 patients. Mineralocorticoid receptor (MR) signaling and its downstream target Galectin-3 (Gal-3) are known to mediate ...
Eva Jover, Lara Matilla, Mattie Garaikoetxea, Amaya Fernández-Celis, Pieter Muntendam, Frédéric Jaisser, Patrick Rossignol, Natalia López-Andrés   +7 more
doaj   +1 more source