Results 41 to 50 of about 242,578 (255)

Clinical Outcomes in Patients with Rheumatoid Arthritis After Switching Between Interleukin-6-Receptor Inhibitors and Janus Kinase Inhibitors: Findings from an Observational Study

Rheumatology and Therapy, 2023
This observational study evaluated response in patients with rheumatoid arthritis (RA) who switched from an interleukin-6 receptor inhibitor (IL-6Ri) to a Janus kinase inhibitor (JAKi) and vice versa.Adult patients with RA, who initiated IL-6Ri or JAKi (following discontinuation of JAKi or IL-6Ri, respectively) during/after December 2012 and had a 6 ...
Anisha B. Dua, Kerri Ford, Stefano Fiore, Dimitrios A. Pappas, Jud C. Janak, Taylor Blachley, Carla Roberts-Toler, Kelechi Emeanuru, Joel M. Kremer, Alan Kivitz   +9 more
openaire   +3 more sources

Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production

Frontiers in Pharmacology, 2020
In the chronic phase following ischemic stroke, glial scars can prevent axonal regeneration and the intensification of inflammation. The protective effect of inhibition of glycogen synthase kinase-3β (GSK3β) or receptor-interacting protein 1 kinase ...
Jin Liu, Yong-Ming Zhu, Yi Guo, Liang Lin, Zhan-Xiang Wang, Feng Gu, Xin-Yi Dong, Ming Zhou, Yi-Fan Wang, Hui-Ling Zhang   +9 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Efficacy and safety of levilimab in the treatment of patients with rheumatoid arthritis [PDF]

Терапевтический архив
Aim. Evaluation in real clinical practice of the effectiveness and safety of levilimab therapy in patients with highly and moderately active rheumatoid arthritis (RA). Materials and methods.
Elena V. Bolotova, Evgeniya V. Yakovleva, Ekaterina K. Ilinykh, Тatiana A. Rassovskaya   +3 more
doaj   +1 more source

BIOCHEMICAL PATHWAYS OF METABOLIC DISORDERS IN PSORIASIS

Juvenis Scientia, 2021
The development of metabolic disorders occurs in psoriasis: insulin resistance, systemic inflammation, atherosclerosis, oxidative stress and obesity. The paper presents pathological biochemical pathways of metabolic disorders development which is caused ...
O. V. Samburskaya, S. Yu Kalinchenko, N. V. Batkaeva   +2 more
doaj   +1 more source

FRI0604 Successful treatment of arthritis induced by checkpoint inhibitors with anti–interleukin-6 receptor antibody: a case series [PDF]

Annals of the Rheumatic Diseases, 2017
Background Immune checkpoint inhibitors (CPIs) have significantly improved outcomes for patients with various cancers. However, CPIs are associated with immune-related adverse events (irAEs). Two to three percent of patients receiving a CPI develop arthritis.
ST Kim, A Diab, M Uemura, S Garcia, P Hwu, J Tayar   +5 more
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Evaluation of the efficacy and safety of levilimab in the treatment of patients with rheumatoid arthritis in real practice

Терапевтический архив
Aim. To evaluate the efficacy and safety of levilimab (LVL) in patients with rheumatoid arthritis (RA) in real clinical practice. Materials and methods.
Elvina R. Myasoutova, Alina R. Iuskaeva, Liana S. Kostakova, Elena V. Sukhorukova, Rifkat Z. Abdrakipov, Diana I. Abdulganieva, Nikita M. Taratorkin   +6 more
doaj   +1 more source

Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma

Haematologica, 2010
Background The deregulation of several transcription factors contribute to the aggressive course of mantle cell lymphoma. This study focuses on survival signals emanating from the tumor environment and involving the signal transducer and activator of ...
Fanny Baran-Marszak, Mohand Boukhiar, Stéphanie Harel, Christelle Laguillier, Claudine Roger, Remy Gressin, Antoine Martin, Remi Fagard, Nadine Varin-Blank, Florence Ajchenbaum-Cymbalista, Dominique Ledoux   +10 more
doaj   +1 more source