Results 91 to 100 of about 14,940,727 (341)

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance.

Cardiovascular Diabetology, 2003
Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (
Szelachowska Malgorzata, Dzienis-Straczkowska Stella, Nikolajuk Agnieszka, Kowalska Irina, Straczkowski Marek, Kinalska Ida   +5 more
doaj   +1 more source

Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche

Cancer Research, 2013
Glioblastoma multiforme (GBM) contains a subpopulation of cancer stem-like cells (CSCs) believed to underlie tumorigenesis and therapeutic resistance. Recent studies have localized CSCs in this disease adjacent to endothelial cells (ECs) in what has been
D. Infanger, Youjin Cho, Brina S. Lopez, S. Mohanan, S. C. Liu, Demirkan B Gursel, J. Boockvar, C. Fischbach   +7 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Metformin’s therapeutic potential in adenomyosis: insights from interleukin 8 level

Italian Journal of Medicine
Adenomyosis is a gynecological disorder characterized by the invasion of endometrial tissue into the myometrium, leading to chronic inflammation and pelvic pain. Interleukin 8 (IL-8) plays a key role in inflammation and pain sensitization in adenomyosis.
Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid   +5 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Carbonic anhydrase 8 regulates basophil activation and interleukin 4 production

Frontiers in Immunology
Carbonic anhydrase (Car) enzymes are a family of metalloenzymes that are traditionally known for their ability to regulate pH and CO2 homeostasis. However, emerging studies now demonstrate that Car family members exhibit lineage-specific expression ...
Jianya Peng, Jianya Peng, Jianya Peng, Chandler B. Sy, Chandler B. Sy, Siyuan Zhao, Arman Sawhney, Arman Sawhney, Vanessa Espinosa, Vanessa Espinosa, Marissa N. Schroeter, Marissa N. Schroeter, Marissa N. Schroeter, John J. Ponessa, John J. Ponessa, John J. Ponessa, Krupa Chavan, Krupa Chavan, Alexander D. Lemenze, Amariliz Rivera, Amariliz Rivera, Tibor Rohacs, Mark C. Siracusa, Mark C. Siracusa   +23 more
doaj   +1 more source

Chemical constituents of tobacco smoke induce the production of interleukin-8 in human bronchial epithelium, 16HBE cells

, 2016
Introduction Interleukin-8 (IL-8) functions as a major chemoattractant and plays pivotal roles in the initiation and development of chronic obstructive pulmonary disease (COPD), and tobacco smoke is a most risk factor contributing to the development of ...
Guojun Zhou, Chengyun Xu, Fangfang Huang, Chunyun Shi, Xiaokai Wu, Yajun Hu, Ximei Wu, Xinbo Lu, Weiqiang Xiao   +8 more
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source