Results 81 to 90 of about 14,940,727 (341)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease

Brazilian Journal of Medical and Biological Research, 2001
Sickle cell disease has a worldwide distribution and is a public health problem in Brazil. Although vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease, there are still several steps of its pathogenesis which are ...
M.S. Gonçalves, I.L. Queiroz, S.A. Cardoso, A. Zanetti, A.C. Strapazoni, E. Adorno, A. Albuquerque, A. Sant'Ana, M.G. dos Reis, A. Barral, M. Barral Netto   +10 more
doaj   +1 more source

Helicobacter pylori and interleukin-8 in gastric cancer.

World Journal of Gastroenterology, 2013
Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H.
Ko-Eun Lee, Khoi Ngoc Pham, Yong Xia, J. Park, Y. Joo, Kyung Keun Kim, Seok-Yong Choi, Young D. Jung   +7 more
semanticscholar   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Cadmium decreases human gingival fibroblast viability and induces pro-inflammatory response associated with Akt and MAPK pathway activation

Frontiers in Toxicology
Smoking and particulate matter 2.5 (PM2.5) expose millions to cadmium (Cd), a toxic heavy metal linked to pro-inflammatory responses, oxidative stress, and disease pathogenesis.
Tipparat Parakaw, Sirada Srihirun, Nathawut Sibmooh, Nisarat Ruangsawasdi, Phisit Khemawoot, Pornpun Vivithanaporn   +5 more
doaj   +1 more source

Determination of Cytokine Levels in Joint Fluid as an Alternative Option for Examination of Internal Temporomandibular Joint Disorders

Česká Stomatologie a Praktické Zubní Lékařství, 2011
Cytokines are extracellular peptides that mediate the strong stimulatory or inhibitory effects on most biological cells. Originally they were considered as candidates for supporting processes of the immune response. It is now clear that they are involved
P. Tvrdý, P. Heinz, L. Hrdina, A. Galandáková, J. Pazdera   +4 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Mechanism of LDH and IL-8 involved in pancreatic cancer pain and the correlation of pain degree [PDF]

Journal of Medical Biochemistry
Background: This research aimed to observe the mechanism of lactate dehydrogenase (LDH) and interleukin 8 (IL8) in pancreatic cancer pain and their correlation with pain degree.
Zhou Zhiming, Guo Zongfeng, Lu Xiaomin, Xu Xiaoqing   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Cxcl8 (Interleukin-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response

Journal of Immunology, 2013
Neutrophils play a pivotal role in the innate immune response. The small cytokine CXCL8 (also known as IL-8) is known to be one of the most potent chemoattractant molecules that, among several other functions, is responsible for guiding neutrophils ...
S. de Oliveira, C. Reyes-Aldasoro, S. Candel, S. Renshaw, V. Mulero, Â. Calado   +5 more
semanticscholar   +1 more source