Results 61 to 70 of about 14,940,727 (341)

Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis

Osteoarthritis and Cartilage, 2015
Summary Objective To determine whether altered IL8 methylation status is associated with increased expression of IL8 in human osteoarthritic (OA) chondrocytes.
A. Takahashi, M. D. de Andrés, K. Hashimoto, E. Itoi, R. Oreffo   +4 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Sepsis beim Hund: Interleukin-6 als prognostischer Parameter [PDF]

, 2007
Wie auch in der Humanmedizin stellen Sepsis und SIRS den behandelnden Arzt in der Veterinärmedizin vor eine große Herausforderung. Eine optimale therapeutische Intervention setzt besonders die Früherkennung dieser Erkrankungen und damit auch die ...
Rau, Stefanie Maria
core   +1 more source

Inhibition of Neutrophil Functions and Antibacterial Effects of Tarragon (Artemisia dracunculus L.) Infusion—Phytochemical Characterization

Frontiers in Pharmacology, 2020
The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry ...
Magdalena Majdan, Magdalena Majdan, Anna K. Kiss, Rafał Hałasa, Sebastian Granica, Ewa Osińska, Monika E. Czerwińska   +6 more
doaj   +1 more source

Soybean Extracts (Glycine Max) with Curcuma, Boswellia, Pinus and Urtica Are Able to Improve Quality of Life in Patients Affected by CP/CPPS: Is the Pro-Inflammatory Cytokine IL-8 Level Decreasing the Physiopathological Link?

Uro, 2022
The present study evaluates the efficacy of a combination of soyabean extracts associated with Curcuma Longa, Boswellia, Pinus pinaster and Urtica dioica (PROSTAFLOG®) in patients affected by CP/CPPS, through the evaluation of interleukin-8 (IL-8) plasma
Tommaso Cai, Umberto Anceschi, Irene Tamanini, Paolo Verze, Alessandro Palmieri   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Correlation between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgical trauma [PDF]

Саратовский научно-медицинский журнал, 2013
Aim: to evaluate the correlations between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgery. Material and methods.
Korsakov I.N., Voskanyan S.E., Naydenov E.V., Timashkov D.A., Chervov A.Yu., Volkov A.A., Bolshakov M.S.   +6 more
doaj  

Interleukin-18 enhances the production of interleukin-8 by eosinophils [PDF]

European Journal of Immunology, 2001
Interleukin-18 (IL-18), a proinflammatory cytokine, leads to IFN-gamma production by NK or T cells, induces Th1 differentiation and suppresses IgE synthesis by B cells when acting on responding cells together with IL-12. IL-18 also exhibits biological activities related to allergic inflammation such as histamine or IL-4 release from basophils and ...
W, Wang, T, Tanaka, H, Okamura, M, Sugita, S, Higa, T, Kishimoto, M, Suemura   +6 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source