Results 11 to 20 of about 58,497 (228)
Role of Intermediate Filaments in Blood–Brain Barrier in Health and Disease [PDF]
Cells, 2021 The blood–brain barrier (BBB) is a highly selective cellular monolayer unique to the microvasculature of the central nervous system (CNS), and it mediates the communication of the CNS with the rest of the body by regulating the passage of molecules into ...
Ece Bayir, Aylin Sendemir
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Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics [PDF]
Cells, 2021 Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins.
Emma J. van Bodegraven +1 more
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Intermediate Filaments in Cellular Mechanoresponsiveness: Mediating Cytoskeletal Crosstalk From Membrane to Nucleus and Back [PDF]
Frontiers in Cell and Developmental Biology, 2022 The mammalian cytoskeleton forms a mechanical continuum that spans across the cell, connecting the cell surface to the nucleus via transmembrane protein complexes in the plasma and nuclear membranes. It transmits extracellular forces to the cell interior,
Anne-Betty Ndiaye +2 more
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Editorial: Intermediate filaments structure, function, and clinical significance [PDF]
Frontiers in Cell and Developmental Biology, 2022 Dolores Pérez-Sala, Ming Guo
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Current Biology, 2021 Cell morphology, architecture and dynamics primarily rely on intracellular cytoskeletal networks, which in metazoans are mainly composed of actin microfilaments, microtubules and intermediate filaments (IFs). The diameter size of 10 nm - intermediate between the diameters of actin microfilaments and microtubules - initially gave IFs their name. However,
Dutour-Provenzano, Gaëlle +1 more
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Frontiers in Cardiovascular Medicine, 2023 BackgroundPostoperative delirium (POD) presents as a serious neuropsychiatric syndrome in patients undergoing off-pump coronary artery bypass grafting (OPCABG) surgery. This is correlated with higher mortality, cognitive decline, and increased costs. The
Ying Ma +7 more
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The intermediate filament network in cultured human keratinocytes is remarkably extensible and resilient. [PDF]
PLoS ONE, 2008 The prevailing model of the mechanical function of intermediate filaments in cells assumes that these 10 nm diameter filaments make up networks that behave as entropic gels, with individual intermediate filaments never experiencing direct loading in ...
Douglas Fudge +5 more
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Is Desmin Propensity to Aggregate Part of its Protective Function?
Cells, 2020 Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF).
Sonia R. Singh +4 more
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eLife, 2020 Actin filaments and microtubules create diverse cellular protrusions, but intermediate filaments, the strongest and most stable cytoskeletal elements, are not known to directly participate in the formation of protrusions.
Yasuko Inaba +4 more
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Using Fluorescence Recovery After Photobleaching data to uncover filament dynamics.
PLoS Computational Biology, 2022 Fluorescence Recovery After Photobleaching (FRAP) has been extensively used to understand molecular dynamics in cells. This technique when applied to soluble, globular molecules driven by diffusion is easily interpreted and well understood.
J C Dallon +5 more
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