Results 41 to 50 of about 154,827 (291)

Star Formation and Gas Phase History of the Cosmic Web

open access: yes, 2014
We present a new method of tracking and characterizing the environment in which galaxies and their associated circumgalactic medium evolve. We use a structure finding algorithm we developed to self-consistently parse and follow the evolution of poor ...
Coughlin, Jared   +4 more
core   +1 more source

An Origin of Narrow Extended Structure in the Interstellar Medium: An Interstellar Contrail Created by a Fast-moving Massive Object

open access: yesThe Astrophysical Journal, 2023
We investigate the thermal condensation caused by a massive object that passes through the interstellar medium with high velocity, and propose a mechanism for creating a filamentary gaseous object, or interstellar contrail.
Kanta Kitajima, Shu-ichiro Inutsuka
doaj   +1 more source

Mechanical properties of branched actin filaments

open access: yes, 2015
Cells moving on a two dimensional substrate generate motion by polymerizing actin filament networks inside a flat membrane protrusion. New filaments are generated by branching off existing ones, giving rise to branched network structures.
Benetatos, Panayotis   +3 more
core   +1 more source

Computational and theoretical modeling of intermediate filament networks: Structure, mechanics and disease [PDF]

open access: yes, 2016
Intermediate filaments, in addition to microtubules and actin microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells.
Buehler, Markus J, Qin, Zhao
core   +1 more source

Cytoskeleton-mediated autophagy regulation in neuroimmune contexts: molecular mechanisms and functional perspectives

open access: yesFrontiers in Immunology
This review systematically summarizes the central roles and molecular mechanisms of the cytoskeletal system—including actin filaments, microtubules (MT), intermediate filaments, and the Septin family—in the regulation of autophagy.
Xingyu Cao, Haolin Zhang, Juan Wang
doaj   +1 more source

Hundred Thousand Degree Gas in the Virgo Cluster of Galaxies [PDF]

open access: yes, 2012
The physical relationship between low-excitation gas filaments at ~10^4 K, seen in optical line emission, and diffuse X-ray emitting coronal gas at ~10^7 K in the centers of many galaxy clusters is not understood.
Abramson   +14 more
core   +2 more sources

Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles

open access: yes, 2009
We examine the mechanism of bundling of cytoskeletal actin filaments by two representative bundling proteins, fascin and espin. Small-angle X-ray studies show that increased binding from linkers drives a systematic \textit{overtwist} of actin filaments ...
B. Alberts   +6 more
core   +1 more source

Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells [PDF]

open access: yes, 2016
Background: Granulosa cell tumors (GCT) are a rare ovarian neoplasm but prognosis is poor following recurrence. Keratin intermediate filaments expressed in these tumors are a diagnostic marker, yet paradoxically, may also constitute a target for ...
Davis, John S.   +4 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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