Results 61 to 70 of about 60,212 (247)

Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders

Cells
Different components of the cytoskeleton are very important determinants of brain development. They orchestrate multiple cellular processes involved in all phases of cerebral cortex development.
Ksenia A. Achkasova, Pavel V. Subbotin, Vadim V. Zhukov, Anastasia E. Filat’eva, Victor S. Tarabykin, Elena V. Kondakova   +5 more
doaj   +1 more source

Neuroendocrine Carcinoma of the Skin (Merkel Cell Carcinoma): Immunocytochemical Study of a Case

The International Journal of Biological Markers, 1988
The immunocytochemical phenotype was evaluated in a case of Merkel cell carcinoma of the skin. Intermediate filaments, i.e. neurofilament, glial fibrillary acid protein, cytokeratins, keratin and panfilament as well as S-100 protein, calcitonin and ...
S. Senatore, L. Zizzi, D. D'Astore, G. Saccani Jotti, M. Gabrielli   +4 more
doaj   +1 more source

Desmin: molecular interactions and putative functions of the muscle intermediate filament protein

Brazilian Journal of Medical and Biological Research, 2004
Desmin is the intermediate filament (IF) protein occurring exclusively in muscle and endothelial cells. There are other IF proteins in muscle such as nestin, peripherin, and vimentin, besides the ubiquitous lamins, but they are not unique to muscle ...
M.L. Costa, R. Escaleira, A. Cataldo, F. Oliveira, C.S. Mermelstein   +4 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Вплив гіпертиреозу на процеси навчання та стан гліальних проміжних філаментів головного мозку щурів

Regulatory Mechanisms in Biosystems, 2014
Досліджено вплив гіпертиреозу на показники окисного стресу, стан гліальних проміжних філаментів і пам’ять. У мозку щурів із гіпертиреозом визначено достовірне зростання вмісту продуктів перекисного окиснення ліпідів і погіршення процесу запам’ятовування.
S. V. Kyrychenko, V. S. Nedzvetsky
doaj   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Intermediate Filaments in Caenorhabditis elegans

, 2004
Abstract More than 70 different genes in humans and 12 different genes in Caenorhabditis elegans encode the superfamily of intermediate filament (IF) proteins. In C. elegans , similar to humans, these proteins are expressed in a cell- and tissue-specific manner, can assemble into heteropolymers and into 5–10 nm wide filaments that account for the ...
Fridkin, A., Karabinos, A., Gruenbaum, Y.   +2 more
openaire   +4 more sources

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

Vimentin is a key regulator of cell mechanosensing through opposite actions on actomyosin and microtubule networks

Communications Biology
The cytoskeleton is a complex network of interconnected biopolymers consisting of actin filaments, microtubules, and intermediate filaments. These biopolymers work in concert to transmit cell-generated forces to the extracellular matrix required for cell
Farid Alisafaei, Kalpana Mandal, Renita Saldanha, Maxx Swoger, Haiqian Yang, Xuechen Shi, Ming Guo, Heidi Hehnly, Carlos A. Castañeda, Paul A. Janmey, Alison E. Patteson, Vivek B. Shenoy   +11 more
doaj   +1 more source