Results 21 to 30 of about 60,212 (247)
The intermediate filament network in cultured human keratinocytes is remarkably extensible and resilient. [PDF]
PLoS ONE, 2008 The prevailing model of the mechanical function of intermediate filaments in cells assumes that these 10 nm diameter filaments make up networks that behave as entropic gels, with individual intermediate filaments never experiencing direct loading in ...
Douglas Fudge +5 more
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eLife, 2020 Actin filaments and microtubules create diverse cellular protrusions, but intermediate filaments, the strongest and most stable cytoskeletal elements, are not known to directly participate in the formation of protrusions.
Yasuko Inaba +4 more
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Capturing intermediate filament networks
eLife, 2022 Mapping intermediate filaments in three dimensions reveals that the organization of these filaments differs across cell types.
Pierre A Coulombe
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Using Fluorescence Recovery After Photobleaching data to uncover filament dynamics.
PLoS Computational Biology, 2022 Fluorescence Recovery After Photobleaching (FRAP) has been extensively used to understand molecular dynamics in cells. This technique when applied to soluble, globular molecules driven by diffusion is easily interpreted and well understood.
J C Dallon +5 more
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Cells, 2016 Intermediate filaments together with actin filaments and microtubules form the cytoskeleton, which is a complex and highly dynamic 3D network. Intermediate filaments are the major mechanical stress protectors but also affect cell growth, differentiation,
Nicole Schwarz, Rudolf E. Leube
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Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy
eLife, 2021 Keratin intermediate filaments are an essential and major component of the cytoskeleton in epithelial cells. They form a stable yet dynamic filamentous network extending from the nucleus to the cell periphery, which provides resistance to mechanical ...
Miriam S Weber +5 more
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Intermediate filaments in cardiomyopathy [PDF]
Biophysical Reviews, 2018 Intermediate filament (IF) proteins are critical regulators in health and disease. The discovery of hundreds of mutations in IF genes and posttranslational modifications has been linked to a plethora of human diseases, including, among others, cardiomyopathies, muscular dystrophies, progeria, blistering diseases of the epidermis, and neurodegenerative ...
Mary, Tsikitis +4 more
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Ndel1 promotes axon regeneration via intermediate filaments. [PDF]
PLoS ONE, 2008 Failure of axons to regenerate following acute or chronic neuronal injury is attributed to both the inhibitory glial environment and deficient intrinsic ability to re-grow. However, the underlying mechanisms of the latter remain unclear.
Cory Toth +9 more
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Computational and Structural Biotechnology Journal, 2021 Cytoskeletal filaments are structures of utmost importance to biological cells and organisms due to their versatility and the significant functions they perform.
Bugra Özdemir, Ralf Reski
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Helical Superstructure of Intermediate Filaments [PDF]
Physical Review Letters, 2019 Intermediate filaments are the least explored among the large cytoskeletal elements. We show here that they display conformational anomalies in narrow microfluidic channels. Their unusual behavior can be understood as the consequence of a previously undetected, large scale helically curved superstructure.
Bouzar, Lila +6 more
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