Results 21 to 30 of about 62,770 (250)
Using Fluorescence Recovery After Photobleaching data to uncover filament dynamics.
PLoS Computational Biology, 2022 Fluorescence Recovery After Photobleaching (FRAP) has been extensively used to understand molecular dynamics in cells. This technique when applied to soluble, globular molecules driven by diffusion is easily interpreted and well understood.
J C Dallon +5 more
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Cells, 2016 Intermediate filaments together with actin filaments and microtubules form the cytoskeleton, which is a complex and highly dynamic 3D network. Intermediate filaments are the major mechanical stress protectors but also affect cell growth, differentiation,
Nicole Schwarz, Rudolf E. Leube
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Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy
eLife, 2021 Keratin intermediate filaments are an essential and major component of the cytoskeleton in epithelial cells. They form a stable yet dynamic filamentous network extending from the nucleus to the cell periphery, which provides resistance to mechanical ...
Miriam S Weber +5 more
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Computational and Structural Biotechnology Journal, 2021 Cytoskeletal filaments are structures of utmost importance to biological cells and organisms due to their versatility and the significant functions they perform.
Bugra Özdemir, Ralf Reski
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Intermediate filament structure
Bioscience Reports, 1985 In a previous communication (Biosci. Rep. 3, 517–525, 1993) we described quantitative X-ray diffraction studies of α-keratin which were shown to be consistent with the presence of finite arrays of repeating units, successive arrays being set down at axial intervals of 470 Å.
R D, Fraser, T P, MacRae
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Ndel1 promotes axon regeneration via intermediate filaments. [PDF]
PLoS ONE, 2008 Failure of axons to regenerate following acute or chronic neuronal injury is attributed to both the inhibitory glial environment and deficient intrinsic ability to re-grow. However, the underlying mechanisms of the latter remain unclear.
Cory Toth +9 more
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Intermediate filaments in cardiomyopathy [PDF]
Biophysical Reviews, 2018 Intermediate filament (IF) proteins are critical regulators in health and disease. The discovery of hundreds of mutations in IF genes and posttranslational modifications has been linked to a plethora of human diseases, including, among others, cardiomyopathies, muscular dystrophies, progeria, blistering diseases of the epidermis, and neurodegenerative ...
Mary, Tsikitis +4 more
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Intermediate Filaments at the Junction of Mechanotransduction, Migration, and Development
Frontiers in Cell and Developmental Biology, 2017 Mechanically induced signal transduction has an essential role in development. Cells actively transduce and respond to mechanical signals and their internal architecture must manage the associated forces while also being dynamically responsive.
Rucha Sanghvi-Shah, Gregory F. Weber
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Helical Superstructure of Intermediate Filaments [PDF]
Physical Review Letters, 2019 Intermediate filaments are the least explored among the large cytoskeletal elements. We show here that they display conformational anomalies in narrow microfluidic channels. Their unusual behavior can be understood as the consequence of a previously undetected, large scale helically curved superstructure.
Bouzar, Lila +6 more
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History and phylogeny of intermediate filaments: Now in insects
BMC Biology, 2011 Intermediate filaments include the nuclear lamins, which are universal in metazoans, and the cytoplasmic intermediate filaments, which are much more varied and form cell type-specific networks in animal cells.
Strelkov Sergei V, Herrmann Harald
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