Results 11 to 20 of about 60,212 (247)
Intermediate Filaments at the Junction of Mechanotransduction, Migration, and Development
Frontiers in Cell and Developmental Biology, 2017 Mechanically induced signal transduction has an essential role in development. Cells actively transduce and respond to mechanical signals and their internal architecture must manage the associated forces while also being dynamically responsive.
Rucha Sanghvi-Shah, Gregory F. Weber
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Lens intermediate filaments [PDF]
Experimental Eye Research, 2009 The ocular lens assembles two separate intermediate filament systems sequentially with differentiation. Canonical 8-11 nm IFs composed of Vimentin are assembled in lens epithelial cells and younger fiber cells, while the fiber cell-specific beaded filaments are switched on as fiber cell elongation initiates.
Paul G Fitzgerald
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Intermediate filaments: Integration of cell mechanical properties during migration [PDF]
Frontiers in Cell and Developmental Biology, 2022 Cell migration is a vital and dynamic process required for the development of multicellular organisms and for immune system responses, tissue renewal and wound healing in adults.
Elvira Infante +1 more
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Role of Intermediate Filaments in Blood–Brain Barrier in Health and Disease [PDF]
Cells, 2021 The blood–brain barrier (BBB) is a highly selective cellular monolayer unique to the microvasculature of the central nervous system (CNS), and it mediates the communication of the CNS with the rest of the body by regulating the passage of molecules into ...
Ece Bayir, Aylin Sendemir
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Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics [PDF]
Cells, 2021 Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins.
Emma J. van Bodegraven +1 more
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Intermediate Filaments in Cellular Mechanoresponsiveness: Mediating Cytoskeletal Crosstalk From Membrane to Nucleus and Back [PDF]
Frontiers in Cell and Developmental Biology, 2022 The mammalian cytoskeleton forms a mechanical continuum that spans across the cell, connecting the cell surface to the nucleus via transmembrane protein complexes in the plasma and nuclear membranes. It transmits extracellular forces to the cell interior,
Anne-Betty Ndiaye +2 more
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Editorial: Intermediate filaments structure, function, and clinical significance [PDF]
Frontiers in Cell and Developmental Biology, 2022 Dolores Pérez-Sala, Ming Guo
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Current Biology, 2021 Cell morphology, architecture and dynamics primarily rely on intracellular cytoskeletal networks, which in metazoans are mainly composed of actin microfilaments, microtubules and intermediate filaments (IFs). The diameter size of 10 nm - intermediate between the diameters of actin microfilaments and microtubules - initially gave IFs their name. However,
Dutour-Provenzano, Gaëlle +1 more
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Frontiers in Cardiovascular Medicine, 2023 BackgroundPostoperative delirium (POD) presents as a serious neuropsychiatric syndrome in patients undergoing off-pump coronary artery bypass grafting (OPCABG) surgery. This is correlated with higher mortality, cognitive decline, and increased costs. The
Ying Ma +7 more
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Is Desmin Propensity to Aggregate Part of its Protective Function?
Cells, 2020 Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF).
Sonia R. Singh +4 more
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