Results 201 to 210 of about 58,497 (228)
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Current Opinion in Cell Biology, 1989
It is likely that future studies involving a molecular biology approach, similar to those described in [7,27,28], will yield fruitful information regarding properties and cellular roles of IF. At this point, our knowledge of the properties and expression of IF remains in stark contrast to our lack of understanding of their biological functions.
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It is likely that future studies involving a molecular biology approach, similar to those described in [7,27,28], will yield fruitful information regarding properties and cellular roles of IF. At this point, our knowledge of the properties and expression of IF remains in stark contrast to our lack of understanding of their biological functions.
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Neuronal Intermediate Filaments
Current Opinion in Cell Biology, 1990Neuronal intermediate filaments (IFs) are 10–12-nm filaments that are expressed in the nervous system. IF proteins belong to a large gene family and the expression of different IF proteins is tissue specific. In the nervous system, different neuronal IFs are expressed in neuroepithelial stem cells, the central nervous system, and peripheral nervous ...
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Neurology, 2002
In this issue of Neurology, Kulhenbaumer et al.1 describe novel mutations of the gene responsible for giant axonal neuropathy (GAN). GAN, a recessive multisystem disorder, presents with a variable phenotype that includes tightly curled hair, CNS involvement, and a progressive sensorimotor axonal neuropathy.2 GAN is an especially instructive reminder of
David N. Herrmann, John W. Griffin
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In this issue of Neurology, Kulhenbaumer et al.1 describe novel mutations of the gene responsible for giant axonal neuropathy (GAN). GAN, a recessive multisystem disorder, presents with a variable phenotype that includes tightly curled hair, CNS involvement, and a progressive sensorimotor axonal neuropathy.2 GAN is an especially instructive reminder of
David N. Herrmann, John W. Griffin
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Assembly of intermediate filaments
BioEssays, 1993AbstractThe assembly of intermediate filaments is a fundamental property of the central rod domain of the individual subunit proteins. This rod domain, with its high propensity for α‐helix formation, is the common and identifying feature of this family of proteins. Assembly occurs in vitro in the absence of other proteins or exogenous sources of energy;
Shoeman, R., Traub, P.
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Functions of intermediate filaments
Cell Motility, 1989Intermediate filaments (IFs) are the most enigmatic component of the eukaryotic cytoskeleton. IFs are often a major component of the cell and are most prominent in the cells of vertebrates. Ultrastructurally similar cytoplasmic filaments have been found in many metazoan phylla and some protists and homologous proteins form the nuclear lamina, a fibrous
M W, Klymkowsky +2 more
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Intermediate filaments in disease
Current Opinion in Cell Biology, 1995Intermediate filaments are major structural proteins encoded by a large multigene family. Their tissue-specific expression makes them important in studies of development, differentiation and pathology. Most intermediate filaments are keratins; recent discoveries of keratin mutations in a range of genetic skin disorders have clarified their role as ...
W H, McLean, E B, Lane
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Intermediate Filament Associated Proteins
2005Intermediate filament associated proteins (IFAPs) coordinate interactions between intermediate filaments (IFs) and other cytoskeletal elements and organelles, including membrane-associated junctions such as desmosomes and hemidesmosomes in epithelial cells, costameres in striated muscle, and intercalated discs in cardiac muscle.
Kathleen J, Green +3 more
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Intermediate filament molecular biology
Current Biology, 1992Epidermal keratin intermediate filaments appear to have a structural function. The functions of other intermediate filaments are being elucidated using a combination of molecular genetic methods, including the expression of dominant negative mutant proteins and gene targeting.
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Intermediate filament-related myopathies
Pediatric Neurology, 2001The dynamic and critical role of intermediate filaments in muscle is highlighted by myopathies characterized by aberrant accumulation of intermediate filaments. In some affected patients, mutations in genes encoding intermediate filaments that are expressed in muscle have been confirmed.
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Cytoskeletal Intermediate Filaments: Practical Applications of Intermediate Filament Analysis
Ultrastructural Pathology, 1987J W, Bolen, M A, McNutt
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