Results 201 to 210 of about 60,212 (247)
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Intermediate filaments and stress
Experimental Cell Research, 2007Before we can explain why so many closely related intermediate filament genes have evolved in vertebrates, while maintaining such dramatically tissue specific expression, we need to understand their function. The best evidence for intermediate filament function comes from observing the consequences of mutation and mis-expression, primarily in human ...
Milos, Pekny, E Birgitte, Lane
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Neuronal Intermediate Filaments
Annual Review of Neuroscience, 1996Neurofilaments (NFs) are the most abundant structural components in large-diameter myelinated axons. Assembled as obligate heteropolymers requiring NF-L and substoichiometric amounts of NF-M and/or NF-H, NF investment into axons is essential for establishment of axonal caliber, itself a key determinant of conduction velocity.
M K, Lee, D W, Cleveland
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Intermediate Filaments in Meningiomas
Journal of Neuropathology and Experimental Neurology, 1985The presence of intermediate filaments (IF) (diameter 10 nm) is a characteristic electron microscopic finding in the cytoplasm of meningioma cells. To identify these IF, immunohistochemical staining for cytokeratins and vimentin and two-dimensional (2-D) gel electrophoresis followed by immunoblot analysis were applied to a group of 16 meningiomas ...
W C, Halliday +3 more
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Intermediate filaments in disease
Current Opinion in Cell Biology, 1995Intermediate filaments are major structural proteins encoded by a large multigene family. Their tissue-specific expression makes them important in studies of development, differentiation and pathology. Most intermediate filaments are keratins; recent discoveries of keratin mutations in a range of genetic skin disorders have clarified their role as ...
W H, McLean, E B, Lane
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Intermediate filament structure
Current Opinion in Cell Biology, 1992In the past year, several new developments concerning the structure of intermediate filament proteins and their assembly into intact intermediate filaments have been made: the coiled-coil structure of a rod domain has been elucidated; the basis of the chain interaction and its role in intermediate filament assembly has been specified; the organization ...
D A, Parry, P M, Steinert
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Intermediate filaments at a glance
Journal of Cell Science, 2001Eukaryotic cells feature two ubiquitous fibrous cytoskeletal polymers in their cytoplasm: F-actin and microtubules. A third fibrous polymer, intermediate filaments (IFs), appeared more recently in evolution ([Fuchs and Cleveland, 1998][1]; [Erber et al., 1998][2]).
P A, Coulombe +3 more
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Current Opinion in Cell Biology, 1989
It is likely that future studies involving a molecular biology approach, similar to those described in [7,27,28], will yield fruitful information regarding properties and cellular roles of IF. At this point, our knowledge of the properties and expression of IF remains in stark contrast to our lack of understanding of their biological functions.
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It is likely that future studies involving a molecular biology approach, similar to those described in [7,27,28], will yield fruitful information regarding properties and cellular roles of IF. At this point, our knowledge of the properties and expression of IF remains in stark contrast to our lack of understanding of their biological functions.
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Neuronal Intermediate Filaments
Current Opinion in Cell Biology, 1990Neuronal intermediate filaments (IFs) are 10–12-nm filaments that are expressed in the nervous system. IF proteins belong to a large gene family and the expression of different IF proteins is tissue specific. In the nervous system, different neuronal IFs are expressed in neuroepithelial stem cells, the central nervous system, and peripheral nervous ...
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Intermediate filament dynamics
Current Opinion in Cell Biology, 1992The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place.
J E, Eriksson, P, Opal, R D, Goldman
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Isolation of Intermediate Filaments
Current Protocols in Cell Biology, 2006AbstractIntermediate filaments (IFs) are found in most eukaryotic cells and are made up of various IF proteins. IFs are highly insoluble in conventional extraction buffers and are therefore commonly purified under denaturing condition. Purified IF proteins can be reassembled into filaments by dialysis.
Conrad L, Leung, Ronald K H, Liem
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