Results 101 to 110 of about 5,866,044 (229)

Importance of the intermediate principal stress on failure and localization behavior in high porosity rocks [PDF]

, 2014
The localization criterion developed by Rudnicki and Rice(1975), whereas intended for low porosity rocks has been found to be applicable to many other types of materials, including high porosity rocks such as sandstone.
Ingraham, Mathew
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

INFLUENCE OF THE VARIATION OF THE INTERMEDIATE PRINCIPAL STRESS ON THE MECHANICAL PROPERTIES OF CLAYS

, 1964
The results of experimental study of deformations, pore-water pressures and shearingstrengths of normally-consolidated clays in three-dimensional stress space are presented.Triaxial tests of cubical specimen (6 cm in height, 2 cm in thickness and 3.5 cm ...
柴田, 徹, 軽部, 大蔵
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

The response of polymethyl methacrylate (PMMA) subjected to large strains, high strain rates, high pressures, a range in temperatures, and variations in the intermediate principal stress

, 2016
This article presents the response of polymethyl methacrylate (PMMA) subjected to large strains, high strain rates, high pressures, a range in temperatures, and variations in the intermediate principal stress. Laboratory data from the literature, and new
D. Casem, J. Bradley, A. Dwivedi, T.J. Holmquist   +3 more
core   +1 more source

Analytical study on plastic loosening zone of weak surrounding rocks tunnel in high cold areas

River
The analysis of plastic loosening zone of tunnels with cold condition, high in situ stress, and weak stratum is the key scientific problem of tunnel construction in cold areas.
Anrun Li, Hao Li, Xiaoyun Shu, Xueyong Xu   +3 more
doaj   +1 more source

Comparison and analysis for prediction accuracy of true triaxial rock strength criterion

Frontiers in Earth Science
To verify the predictive accuracy of existing strength criteria on true triaxial strength experimental data, understand the characteristics of different strength criteria, and provide a basis for selecting strength criteria for engineering applications ...
Shiwei He, Hong Cheng, Lin Cheng, Feiyu Yuan, Mingming Zhang   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Comparative analysis and application of a new stability model for the tunnel face with Mogi-coulomb criterion

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
Tunnel face stability is a fundamental concern in underground construction, essential for safe and efficient project completion. Traditional models offer various approaches to tunnel face stability analysis; however, they often lack integrating of ...
Junchao Chen, Zhenglu Che, Qilong Song, Wenyuan Song, Xinghong Jiang, Kai Xu   +5 more
doaj   +1 more source