Results 101 to 110 of about 421,581 (294)

Experimental Study on Cyclic Loading and Unloading of Remodeled Loess Using True Triaxial Testing

Buildings
True triaxial tests of cyclic loading and unloading were carried out on remodeled loess, and the effects of the anisotropic consolidation ratio (K=σ1c/σ3c), intermediate principal stress coefficient (b=σ2−σ3/σ1−σ3), and cyclic loading on the deformation ...
Dan Guo, Shuai Shao, Shengjun Shao
doaj   +1 more source

Ultimate Bearing Capacity of Strip Foundations in Unsaturated Soils considering the Intermediate Principal Stress Effect

Advances in Civil Engineering, 2020
The reasonable determination of ultimate bearing capacity is crucial to an optimal design of shallow foundations. Soils surrounding shallow foundations are commonly located above the water table and are thus in an unsaturated state.
Qing Yan, Junhai Zhao, Changguang Zhang, Jintai Wang   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Three-dimensional FDEM numerical simulation of failure processes observed in Opalinus Clay laboratory samples

Journal of Rock Mechanics and Geotechnical Engineering, 2014
This study presents the first step of a research project that aims at using a three-dimensional (3D) hybrid finite-discrete element method (FDEM) to investigate the development of an excavation damaged zone (EDZ) around tunnels in a clay shale formation ...
Omid Mahabadi, Patrick Kaifosh, Paul Marschall, Tim Vietor   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Analytical study on plastic loosening zone of weak surrounding rocks tunnel in high cold areas

River
The analysis of plastic loosening zone of tunnels with cold condition, high in situ stress, and weak stratum is the key scientific problem of tunnel construction in cold areas.
Anrun Li, Hao Li, Xiaoyun Shu, Xueyong Xu   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Novel True Triaxial Apparatus for Testing Shear Seepage in Gas-Solid Coupling Coal

Geofluids, 2018
To study the effects of shear stress on the mechanical and seepage properties of gas-bearing coal in three-dimensional stress conditions, a novel true triaxial apparatus (TTA) was developed for the rigid loading of the major principal stress σ1 and the ...
Gang Wang, Pengfei Wang, Yangyang Guo, Wenxin Li   +3 more
doaj   +1 more source