Results 91 to 100 of about 5,866,044 (229)
工程科学与技术, 2021 Subjected to complex loads, such as wave, earthquake and traffic loads, the corresponding stress states of the foundation soil are complicated. The simultaneous variations of the deviatoric stress and principal stress direction occur in practical ...
Yuke WANG +5 more
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2013 One interesting aspect of soil response is the sensitivity of the mechanical behaviour to the intermediate principal stress. In this study, a fundamental mechanism that explains the influence of the intermediate stress ratio (b) on soil shear strength is
O'Sullivan, C. +3 more
core +1 more source
Effects of Inherent Fabric Anisotropy and Intermediate Principal Stress on Constitutive Behavior of Uncemented and Cemented Sands [PDF]
, 2016 Sand response changes with intensity of cementation bonds between sand grains, magnitude of intermediate principal stress and with fabric anisotropy. First a critical state bounding surface plasticity model is presented in this paper.
Mojtaba Rahimi +3 more
core +1 more source
KSCE Journal of Civil Engineering, 2019 Rockfill material is widely used for construction of high rockfill dam, which undergoes significant particle breakage and three-dimensional stress path induced by the water pressure, earthquake, etc. The dilatancy equation, defined as the function of the dilatancy dg and the stress ratio η, is regarded as the foundation of elastoplastic constitutive ...
Wanli Guo, Li Chen
openaire +1 more source
Experimental Study on Cyclic Loading and Unloading of Remodeled Loess Using True Triaxial Testing
BuildingsTrue triaxial tests of cyclic loading and unloading were carried out on remodeled loess, and the effects of the anisotropic consolidation ratio (K=σ1c/σ3c), intermediate principal stress coefficient (b=σ2−σ3/σ1−σ3), and cyclic loading on the deformation ...
Dan Guo, Shuai Shao, Shengjun Shao
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2010 Estimating passive earth pressure accurately is very important when designing retaining wall. Based on the unified strength theory and plane strain assumption, an analytical solution has been developed to determine the passive lateral earth pressure ...
Jian Zhang +4 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source