Results 91 to 100 of about 74,912 (281)

Use of DEM and elastic stability analysis to explain the influence of the intermediate principal stress on shear strength

, 2013
One interesting aspect of soil response is the sensitivity of the mechanical behaviour to the intermediate principal stress. In this study, a fundamental mechanism that explains the influence of the intermediate stress ratio (b) on soil shear strength is
O'Sullivan, C., Wadee, M.A., Hanley, K.J., Barreto, D.   +3 more
core   +1 more source

Experimental Study on Cyclic Loading and Unloading of Remodeled Loess Using True Triaxial Testing

Buildings
True triaxial tests of cyclic loading and unloading were carried out on remodeled loess, and the effects of the anisotropic consolidation ratio (K=σ1c/σ3c), intermediate principal stress coefficient (b=σ2−σ3/σ1−σ3), and cyclic loading on the deformation ...
Dan Guo, Shuai Shao, Shengjun Shao
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

INFLUENCE OF THE VARIATION OF THE INTERMEDIATE PRINCIPAL STRESS ON THE MECHANICAL PROPERTIES OF CLAYS

, 1964
The results of experimental study of deformations, pore-water pressures and shearingstrengths of normally-consolidated clays in three-dimensional stress space are presented.Triaxial tests of cubical specimen (6 cm in height, 2 cm in thickness and 3.5 cm ...
柴田, 徹, 軽部, 大蔵
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA

, 2017
The actin and intermediate filament cytoskeletons contribute to numerous cellular processes, including morphogenesis, cytokinesis and migration. These two cytoskeletal systems associate with each other, but the underlying mechanisms of this interaction ...
Eriksson, John E., Jiu, Yaming, Peränen, Johan, Lappalainen, Pekka, Schaible, Niccole, Cheng, Fang, Krishnan, Ramaswamy   +6 more
core   +1 more source

Analytical study on plastic loosening zone of weak surrounding rocks tunnel in high cold areas

River
The analysis of plastic loosening zone of tunnels with cold condition, high in situ stress, and weak stratum is the key scientific problem of tunnel construction in cold areas.
Anrun Li, Hao Li, Xiaoyun Shu, Xueyong Xu   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source