Results 91 to 100 of about 421,581 (294)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of intermediate principal stress and minimum principal stress unloading stress path and rate on energy evolution of sandstone under true triaxial compression

Meitan xuebao
In the process of deep coal mining, the unloading stress path and unloading rate of deep rock are complicated and changeable due to the influence of excavation and unloading.
Zhixi LIU, Guangming ZHAO, Xiangrui MENG, Zhihong QIN   +3 more
doaj   +1 more source

Transition Path Theory from Biased Simulations

, 2018
Transition Path Theory (TPT) provides a rigorous framework to investigate the dynamics of rare thermally activated transitions. In this theory, a central role is played by the forward committor function q^+(x), which provides the ideal reaction ...
Bartolucci, G., Faccioli, P., Orioli, S.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Melt homogenization and self-organization of chalcogenides glasses: evidence of sharp rigidity, stress and nanoscale phase separation transitions in the GexSe100-x binary

, 2011
A Raman profiling method is used to monitor growth of GexSe100-x melts and reveals a two step process of homogenization. Resulting homogeneous glasses show the non-reversing enthalpy at Tg, {\Delta}Hnr(x), to show a square-well like variation with x ...
Anderson, Angell, Azoulay, Barre, Bauchy, Bhosle, Boolchand, Boolchand, Boolchand, Boolchand, Boolchand, Boolchand, Boolchand, Boolchand, Bresser, Bridenbaugh, Brière, Chakravarty, Chen, Chen, Chen, Chubynsky, Feltz, Feng, Franzblau, Georgiev, Gjersing, Guin, He, Jackson, Jacobs, Kauzmann, Kibalchenko, Madhu, Mahadevan, Massobrio, Mauro, Micoulaut, Micoulaut, Micoulaut, Micoulaut, Micoulaut, Micoulaut, Murase, Novita, Petri, Phillips, Qu, Richet, Salmon, Selvanathan, Senapati, Sharma, Sreeram, Stolen, Thomas, Thorpe, Wang, Wang, Yonezawa   +59 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Effect of Intermediate Principal Stress on the Strength, Deformation, and Permeability of Sandstone

Energies, 2018
Although the mechanical behaviors and flow aspects of sandstone have been previously investigated, studies of the effect of the intermediate principal stress (σ2) on the strength, deformation, and permeability of sandstone are lacking. In this work,
Zhenlong Song, Minghui Li, Guangzhi Yin, Pathegama Gamage Ranjith, Dongming Zhang, Chao Liu   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The influence of out-of-plane stress on a plane strain problem in rock mechanics [PDF]

, 1987
This paper analyses the stresses and displacements in a uniformly prestressed Mohr-Coulomb continuum, caused by the excavation of an infinitely long cylindrical cavity.
Reed, M B
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source