Results 71 to 80 of about 5,866,044 (229)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Effects of intermediate principal stress on creep closure of storage caverns in Maha Sarakham salt [PDF]
, 2017 True triaxial creep tests are performed to determine the effects of the intermediate principal stress on the timedependent behavior of the Maha Sarakham salt.
Supattra Khamrat +2 more
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Yantu gongcheng xuebaoIn conventional loess cutting slope design, the direct shear test fails to replicate the stress boundary conditions of excavation-induced unloading, leading to discrepancies in shear strength parameters and subsequent stability analysis.
WANG Zhipeng 1, 2, HU Haijun 1, ZHANG Jiachao 1, YANG Yang 3
doaj +1 more source
Evolution of mining‐induced stress in fully mechanized top‐coal caving under high horizontal stress
Energy Science & Engineering, 2020 In fully mechanized top‐coal caving (FMTC), the effects of coal caving are closely related to the degree of damage to the top‐coal which is determined by the stress state therein.
Yuming Huo +4 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
PLoS ONEThe macroscopic failure of rock masses is essentially the result of the propagation, interaction, and eventual coalescence of internal defects such as flaws under stress.
Na Wu +4 more
doaj +1 more source
Yantu gongcheng xuebao, 2018 Based on the unified solution of shear strength for unsaturated soils, a unified solution of Meyerhof’s ultimate bearing capacity for strip foundation is obtained by considering the effects of intermediate principal stress, matric suction and strength ...
ZHANG Chang-guang 1,2, YAN Qing 1, WU Li-zhou 2, CAO Xue-ye 1, ZHANG Cheng-lin 1
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source