Results 51 to 60 of about 74,912 (281)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Triaxial stress and failure modes in hydrothermal mineral systems [PDF]
, 2023 Rock mechanics experiments show that the magnitude of the intermediate principal stress significantly affects rock failure. Since triaxial stress states (no principal stress is zero) are ubiquitous in the crust, and polyaxial axial states (all three ...
Blenkinsop, T. G., T. G. Blenkinsop
core +1 more source
Effect of large particle content on strength and failure mode of binary granular mixture in shear under plane strain condition [PDF]
E3S Web of ConferencesThe strength and failure modes of binary granular mixture composed of two different sized particles, such as gravel and sand, vary depending on the content of gravel (large particle content).
Taue Masato +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Evolution of mining‐induced stress in fully mechanized top‐coal caving under high horizontal stress
Energy Science & Engineering, 2020 In fully mechanized top‐coal caving (FMTC), the effects of coal caving are closely related to the degree of damage to the top‐coal which is determined by the stress state therein.
Yuming Huo +4 more
doaj +1 more source
Advances in Civil Engineering, 2021 The TRW-3000 true triaxial rock testing machine was used to conduct loading and unloading tests of sandstone under different σ2, and the true triaxial lateral unloading mechanics and energy characteristics of sandstone under different σ2 were studied ...
Yingjie Zhang +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source