Results 51 to 60 of about 5,866,044 (229)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Influence of the intermediate principal stress on the stress–strain–strength behaviour of a completely decomposed granite soil

, 2012
The most widely encountered soil type in Hong Kong is completely decomposed granite (CDG). In this paper, the influence of the intermediate principal stress through b-values on the stress–strain–strength behaviour of a recompacted CDG soil is ...
M. KUMRUZZAMAN, J.-H. YIN
core   +1 more source

Effects of principal stress rotation and drainage on the resilient stiffness of railway foundations

, 2013
Railway foundations play an integral role in controlling the stability of the overlying track structure and the maintenance of the overall track geometry.
Mamou, A.
core   +1 more source

Mechanical characteristics of plane strain unloading conditions with different initial states

Yantu gongcheng xuebao
For the plane strain unloading issues in loess engineering, the lateral unloading plain strain tests on the loess with various initial states (intact, remolded and saturated) under different confining pressures and water contents are carried out by using
ZHANG Yu 1, 2, ZHAO Yang 1, LIU Keji 1, YE Sheng 1, LIU Jin 1, 2, DING Xiao 1, ZHANG Meng 1, QU Yonglong 1
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Numerical simulation on the simultaneous stress interference of parallel multiple hydraulic fractures

Energy Exploration & Exploitation, 2021
During horizontal well staged fracturing, there is stress interference between multiple transverse fractures in the same perforation cluster. Theoretical analysis and numerical calculation methods are applied in this study.
Weiyong Lu, Changchun He
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Proposed Algorithm to Compute the Stress-Strain Plastic Region and Displacement of a Deep-Lying Tunnel Considering Intermediate Stress and Strain-Softening Behavior

, 2021
Past studies on deep-lying tunnels under the assumption of plane strain have generally neglected the influence of intermediate principal stress even though this affects the surrounding rocks in the plastic zone.
Xiangtian Zheng, Caihua Shen, Jinwang Li, Xiufeng He   +3 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source