Results 61 to 70 of about 5,866,044 (229)

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers [PDF]

, 2015
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive.
Lehtimaki, Jaakko, Eriksson, John E., Jiu, Yaming, Yaming Jiu, Xiaonan Liu, Jäälinoja, Harri, Cheng, Fang, John E. Eriksson, Jaakko Lehtimäki, Fang Cheng, Liu, Xiaonan, Varjosalo, Markku, Markku Varjosalo, Lappalainen, Pekka, Tojkander, Sari, Harri Jäälinoja, Pekka Lappalainen, Sari Tojkander   +17 more
core   +1 more source

Effect of large particle content on strength and failure mode of binary granular mixture in shear under plane strain condition [PDF]

E3S Web of Conferences
The strength and failure modes of binary granular mixture composed of two different sized particles, such as gravel and sand, vary depending on the content of gravel (large particle content).
Taue Masato, Nakata Yukio, Kajiyama Shintaro   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Experimental study on mechanical properties of fissured loess under true triaxial conditions

Scientific Reports
Fissured loess is one of the important factors that cause geological disasters in the Loess Plateau. This paper analyzes the mechanical characteristics of fissured loess under different confining pressures and different intermediate effective principal ...
Jielong Sun, Rui Chen, Xingyu Qin, Bing Lou, Yu Wang, Wenbo Li   +5 more
doaj   +1 more source

Three-directional permeability evolution characteristics of cyan sandstone under true triaxial conditions

Journal of Rock Mechanics and Geotechnical Engineering
Investigating the triaxial permeability evolution of rocks under in situ stress conditions is a critical challenge for the safe construction of deep, water-rich underground projects.
Yili Lou, Chenghua Shi, Keyue Zheng, Liang Wang, Chaojun Jia, Wei Yi   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Unified Solution for Surrounding Rock of Roadway Considering Seepage, Dilatancy, Strain-Softening and Intermediate Principal Stress

, 2022
The analytic solution for surrounding rock of roadway is of significance for stability analysis and roadway support. However, analytical solution for surrounding rock of roadway which took influences of water seepage, strain softening, dilatancy and ...
Fei Huang, Zehua Jiang, Jintao Zhao, Shuqing Li, Zhigang Yuan   +4 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Dilation and energy evolution mechanisms of sandstone under true-triaxial mining unloading conditions

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
The study of sandstone dilation characteristics under actual mining and excavation conditions promotes the safe and efficient development of underground engineering.
Wenpu Li, Ze Wang, Guorui Feng, Huan Zhang, Jiahui Du, Hao Li, Minke Duan   +6 more
doaj   +1 more source