Results 61 to 70 of about 74,912 (281)

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

, 2015
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive.
Lehtimaki, Jaakko, Eriksson, John E., Jiu, Yaming, Yaming Jiu, Xiaonan Liu, Jäälinoja, Harri, Cheng, Fang, John E. Eriksson, Jaakko Lehtimäki, Fang Cheng, Liu, Xiaonan, Varjosalo, Markku, Markku Varjosalo, Lappalainen, Pekka, Tojkander, Sari, Harri Jäälinoja, Pekka Lappalainen, Sari Tojkander   +17 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Experimental study on mechanical properties of fissured loess under true triaxial conditions

Scientific Reports
Fissured loess is one of the important factors that cause geological disasters in the Loess Plateau. This paper analyzes the mechanical characteristics of fissured loess under different confining pressures and different intermediate effective principal ...
Jielong Sun, Rui Chen, Xingyu Qin, Bing Lou, Yu Wang, Wenbo Li   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of principal stress rotation and drainage on the resilient stiffness of railway foundations

, 2013
Railway foundations play an integral role in controlling the stability of the overlying track structure and the maintenance of the overall track geometry.
Mamou, A.
core  

A Proposed Algorithm to Compute the Stress-Strain Plastic Region and Displacement of a Deep-Lying Tunnel Considering Intermediate Stress and Strain-Softening Behavior

, 2021
Past studies on deep-lying tunnels under the assumption of plane strain have generally neglected the influence of intermediate principal stress even though this affects the surrounding rocks in the plastic zone.
Xiangtian Zheng, Caihua Shen, Jinwang Li, Xiufeng He   +3 more
core   +1 more source

Dilation and energy evolution mechanisms of sandstone under true-triaxial mining unloading conditions

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
The study of sandstone dilation characteristics under actual mining and excavation conditions promotes the safe and efficient development of underground engineering.
Wenpu Li, Ze Wang, Guorui Feng, Huan Zhang, Jiahui Du, Hao Li, Minke Duan   +6 more
doaj   +1 more source

Stability analysis and parameter optimization experiment of loess cutting slopes based on unloading path

Yantu gongcheng xuebao
In conventional loess cutting slope design, the direct shear test fails to replicate the stress boundary conditions of excavation-induced unloading, leading to discrepancies in shear strength parameters and subsequent stability analysis.
WANG Zhipeng 1, 2, HU Haijun 1, ZHANG Jiachao 1, YANG Yang 3
doaj   +1 more source

Unified solution of Meyerhof’s ultimate bearing capacity for strip foundation resting on unsaturated soils

Yantu gongcheng xuebao, 2018
Based on the unified solution of shear strength for unsaturated soils, a unified solution of Meyerhof’s ultimate bearing capacity for strip foundation is obtained by considering the effects of intermediate principal stress, matric suction and strength ...
ZHANG Chang-guang 1,2, YAN Qing 1, WU Li-zhou 2, CAO Xue-ye 1, ZHANG Cheng-lin 1
doaj   +1 more source