Results 61 to 70 of about 75,071 (250)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Experimental study on mechanical properties of fissured loess under true triaxial conditions
Scientific ReportsFissured loess is one of the important factors that cause geological disasters in the Loess Plateau. This paper analyzes the mechanical characteristics of fissured loess under different confining pressures and different intermediate effective principal ...
Jielong Sun +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Influence Of Intermediate Principal Stress On Solution Of Planar Stability Problems
, 2015 {"references": ["P. V. Lade \"Assessment of test data for selection of 3-D failure criterion for sand.\" Int. J. Numer. Anal. Meth. Geomech, 2006; 30:307\u2013333.", "R. O. Davis and A. P. S. Selvadurai, Plasticity and Geomechanics. Cambridge University Press, 2002, 287 p.", "H.
M. Jahanandish, M. B. Zeydabadinejad
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Geomechanics and Geophysics for Geo-Energy and Geo-ResourcesThe study of sandstone dilation characteristics under actual mining and excavation conditions promotes the safe and efficient development of underground engineering.
Wenpu Li +6 more
doaj +1 more source
Evolution of mining‐induced stress in fully mechanized top‐coal caving under high horizontal stress
Energy Science & Engineering, 2020 In fully mechanized top‐coal caving (FMTC), the effects of coal caving are closely related to the degree of damage to the top‐coal which is determined by the stress state therein.
Yuming Huo +4 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Yantu gongcheng xuebaoIn conventional loess cutting slope design, the direct shear test fails to replicate the stress boundary conditions of excavation-induced unloading, leading to discrepancies in shear strength parameters and subsequent stability analysis.
WANG Zhipeng 1, 2, HU Haijun 1, ZHANG Jiachao 1, YANG Yang 3
doaj +1 more source