Results 51 to 60 of about 806,096 (311)

Evaluation of Meropenem Extended Versus Intermittent Infusion Dosing Protocol in Critically Ill Patients

Journal of Intensive Care Medicine, 2018
Extended infusion (EI) administration of β-lactams can improve target attainment in critically ill patients with altered pharmacokinetics/pharmacodynamics.
N. Ahmed, S. Jen, Diana Altshuler, J. Papadopoulos, V. Pham, Yanina Dubrovskaya   +5 more
semanticscholar   +1 more source

A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract [PDF]

, 2016
Background: Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with ...
E. Soulis, F. Y. Coxon, J. S. Graham, K. Boyd, L. R. Wall, M. Highley, M. M. Eatock, P. Bützberger-Zimmerli, S. Harden, T. R. J. Evans, T. S. Maughan   +10 more
core   +1 more source

The intermittent bolus infusions of rapid infusion system caused hypothermia during liver transplantation [PDF]

Korean Journal of Anesthesiology, 2013
CC Hypothermia is frequently encountered during major operations despite many efforts to prevent this complication. Numer ous reports have identified the adverse effects of hypo thermia including coagulopathy, acidosis, alterations in response to pharmacological agents, detrimental cardiac arrhythmias, and a mortality rate of near 100% for cases with a
Gaab-Soo Kim, Justin Sangwook Ko, Jae Myung Yu, Ha Yeon Kim   +3 more
openaire   +3 more sources

Comparative Study of Continuous Pralidoxime Infusion versus Intermittent Dosing: Application of High-Performance Liquid Chromatography Method on Serum of Organophosphate Poisoned Patients [PDF]

Asia Pacific Journal of Medical Toxicology, 2013
Background: The effective therapeutic dose of pralidoxime methylsulphate for organophosphate (OP) poisoning is necessary to be clarified. This study was designed to comparatively assess the blood level of pralidoxime (BPL) and clinical outcomes in OP ...
Girish Thunga, Sureshwar Pandey, Sreedharan Nair, Rama Mylapuri, Sudha Vidyasagar, Vijayanarayana Kunhikatta, Bhrugu Pariti, Masoom Priyadarshini   +7 more
doaj  

A fresh look at paralytics in the critically ill: real promise and real concern. [PDF]

, 2012
Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails.
Kenyon, Nicholas J, Price, David, Stollenwerk, Nicholas   +2 more
core   +2 more sources

Bolus versus continuous infusion of nitroglycerin for the treatment of acute hypertensive heart failure

International Journal of the Cardiovascular Academy, 2022
Background: The use of intravenous nitroglycerin by intermittent bolus doses in hypertensive acute heart failure patients (AHF) is still unclear. Aim and Objectives: This study aimed to determine intermittent bolus nitroglycerin's effect on the use of ...
Mahmoud Shawky Abdelmoneum, Mohammed I Eitta, Khaled A Elrabat, Ahmed Mahmoud Bendary   +3 more
doaj   +1 more source

Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics

Pharmacy
Cephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effective antibiotic ...
Abbie L. Blunier, R. Jake Crocker, Rachel Foster, Stephanie S. May, Caroline E. Powers, P. Brandon Bookstaver   +5 more
doaj   +1 more source

Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial.

JAMA Internal Medicine, 2020
Importance Few high-quality studies have clarified whether hypertonic saline is best administered as slow continuous infusion (SCI) therapy or rapid intermittent bolus (RIB) therapy for symptomatic severe hyponatremia.
S. H. Baek, Y. Jo, Soyeon Ahn, K. Medina-Liabres, Y. Oh, Jung Bok Lee, Sejoong Kim   +6 more
semanticscholar   +1 more source

Antibacterial Activity and Optimal Treatment of Ceftazidime-Avibactam and Aztreonam-Avibactam Against Bloodstream Infections Caused by Carbapenem-Resistant Klebsiella pneumoniae

Frontiers in Pharmacology, 2021
Objectives: This work was to investigate the activity and optimal treatments of ceftazidime-avibactam (CZA) and aztreonam-avibactam (AZA) against bloodstream infections caused by carbapenem resistant Klebsiella pneumoniae (BSIs-CRKP).Methods: A total of ...
Wei Yu, Yunbo Chen, Ping Shen, Jinru Ji, Chaoqun Ying, Zhiying Liu, Luying Xiong, Yunqing Qiu, Yonghong Xiao   +8 more
doaj   +1 more source

Prolonged versus intermittent β-lactam antibiotics intravenous infusion strategy in sepsis or septic shock patients: a systematic review with meta-analysis and trial sequential analysis of randomized trials

Journal of Intensive Care, 2020
Background The prolonged β-lactam infusion strategy has emerged as the standard treatment for sepsis or septic shock despite its unknown efficacy. This study aimed to assess the efficacy of prolonged versus intermittent β-lactam antibiotics infusion on ...
Yutaka Kondo, K. Ota, Haruki Imura, Naoki Hara, N. Shime   +4 more
semanticscholar   +1 more source