Results 51 to 60 of about 225,280 (265)
US Monetary Policy and International Bond Markets [PDF]
Finance and Economics Discussion Series, 2018 This paper uses high-frequency data to analyze the effects of US monetary policy--during the conventional and unconventional policy regimes--on foreign government bonds markets in advanced and emerging market economies. The results indicate that an expansionary US monetary policy steepens the foreign yield curve--denominated in local currency--during a
Vivian Yue +2 more
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
International Journal of Concrete Structures and MaterialsThe bond characteristic of beam longitudinal rebar penetrating reinforced concrete beam-column interior joints under cyclic loading is influenced by various factors such as compressive strength of concrete, yield strength of main rebar, diameter, and ...
Min-Su Jo +6 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
International Bond Return Predictability
, 2021 We study time-varying risk premia across international bond- and equity markets by running predictive regressions of excess returns. We nd that the single factor of Cochrane and Piazzesi (2005) and global factor of Dahlquist and Hasseltoft (2013) have lost some of their predictive power in later years, but they both individually and jointly predict ...
Elnan, André Lerberg +1 more
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Scientific ReportsConcrete-filled steel tubes (CFSTs) have been increasingly utilized in engineering due to their excellent mechanical properties. Ensuring a solid bond between a steel tube and concrete is essential for optimizing their synergistic effect.
Nianchun Deng +5 more
doaj +1 more source
Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network. [PDF]
PLoS ONE, 2011 BACKGROUND: Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s).
Joakim E Swedberg +5 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source