Results 71 to 80 of about 2,256,279 (307)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Effect of variability of human bone morphometric parameters on the uncertainty of internal bone marrow doses due to ⁹⁰Sr

Радиационная гигиена
Computational phantoms are used to calculate the doses of internal exposure of active bone marrow. The computational phantoms of ICRP were created for a reference man with anatomical characteristics typical of an average individual.
E. A. Shishkina, P. A. Sharagin, E. I. Tolstykh   +2 more
doaj   +1 more source

Credit Risk Assessment Considering Variations in Exposure: Application to Commitment Lines [PDF]

With the worldwide financial market confUsion caused by the subprime mortgage problem and the increase in credit line contracts with relaxed covenants, there are cases where financial institutions are facing demands to provide additional credit to ...
Shigeaki Fujiwara
core   +3 more sources

Perceptual Calibration of F0 Production: Evidence from Feedback Perturbation [PDF]

, 2000
Hearing one’s own speech is important for language learning and maintenance of accurate articulation. For example, people with postlinguistically acquired deafness often show a gradual deterioration of many aspects of speech production.
Jones, Jeffery A., Munhall, Kevin
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

MAJOR OUTCOMES OF THE WORK PERFORMED BY ST. PETERSBURG RESEARCH INSTITUTE OF RADIATION HYGIENE AFTER PROFESSOR P. V. RAMZAEV ON THE IMPLEMENTATION OF THE FEDERAL TARGETED PROGRAM “MITIGATION OF THE RADIATION ACCIDENTS’CONSEQUENCES UNTIL 2015” AND OF THE “JOINT ACTIVITIES PROGRAM ON MITIGATION OF THE CHERNOBYL DISASTER WITHIN THE UNION STATE FOR THE PERIOD UNTIL 2016“

Радиационная гигиена, 2016
The article presents major results of the work performed by St. Petersburg Research Institute of Radiation Hygiene after Professor P. V. Ramzaev on public contracts signed within the implementation of the Federal targeted program “ Mitigation of the ...
A. N. Barkovskiy, G. Ya. Bruk, A. A. Bratilova, O. S. Kravtsova   +3 more
doaj  

Conversion from the frequency of chromosome translocations in T-lymphocytes to the bone marrow dose in the long-term period after internal 89,90 Sr exposure

Радиационная гигиена
Cytogenetic Fluorescence In Situ Hybridization studies, that allow assessing the frequency of stable chromosome  aberrations  in  circulating  T  lymphocytes,  are  commonly  used  in  retrospective  dosimetry  in  cases of uniform whole-body exposure ...
E. I. Tolstykh
doaj   +1 more source

Dose formation and hematologic effects with prolonged internal exposure of rats by isotope 131I [PDF]

Ядерна фізика та енергетика, 2014
Processes in single dose formation and long-term domestic revenue 131I in rats was investigated. Original method of estimating absorbed doses in hemacyte for makrodozimetric indicators was proposed. Dose factors for hemacyte and the dynamics of the blood-
E. A. Sova, I. P. Drozd
doaj  

Sun exposure drives Antarctic cryptoendolithic community structure and composition [PDF]

, 2019
The harsh environmental conditions of the ice-free regions of Continental Antarctica are considered one of the closest Martian analogues on Earth. There, rocks play a pivotal role as substratum for life and endolithism represents a primary habitat for ...
Coleine, Claudia, Onofri, Silvano, Selbmann, Laura, Stajich, Jason E, Zucconi, Laura   +4 more
core