Results 51 to 60 of about 4,759,037 (353)

Epidemiological Patterns of Diabetes Mellitus in The United States of America: An Observational Multicenter Analysis From 1990 to 2024

ASIDE Internal Medicine
Introduction: Diabetes mellitus represents a significant public health challenge, however, the current trends in its epidemiology remain incompletely characterized. This study aimed to analyze epidemiological changes and demographic patterns in diabetes
Ahmed Y Azzam, Luis Medina Mora, Mahmoud M. Morsy, Muhammed Amir Essibayi, David J. Altschul, Mahmoud Nassar   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Demographic Factors of Colorectal Cancer Patients with Paralytic Ileus Among Adults in the United States: A Retrospective Study for Mortality Trends

ASIDE Internal Medicine
Background: Paralytic ileus is a serious postoperative complication among individuals with colorectal cancer (CRC). Although mortality trends for CRC and paralytic ileus have been described separately, long-term national patterns involving both ...
Waheed Qaisi, Mirna Hussein, Pakeezah Tabasum, Mohamed Wagdy, Nidal Mutawodeh, Abdallah Abdallah , Mohammed Mereb, Youssef Heikal   +7 more
doaj   +1 more source

Physician Empathy in Public and Private Internal Medicine Residency Training Programs in Pasig City [PDF]

, 2020
Melody Hope L Lee Yu, Rafael Carlos C Aniceto, Dave Ryan A Dela Cruz, Mary Stephanie M Dofitas, Kenneth Brian M Fernando, Joseph Anthony Lachica   +5 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Disparities and Trends in Polycythemia Vera–Related Mortality in U.S. Adults Aged ≥45 Years from 1999 to 2023

ASIDE Internal Medicine
Background: Polycythemia vera (PV) is a rare myeloproliferative neoplasm characterized by excessive red blood cell production, leading to increased risk of thrombosis and other complications.
Alyaa Ahmed Ibrahim, Mohamed Fawzi Hemida, Mirna Hussein, Maryam Saghir, Mohammad Rayyan Faisal, FNU Kritika, Krish Patel, Amro Ali, Eshal Saghir, Mahmoud Tablawy, Abdelrhman H. Mohamed, Amr Arafa   +11 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

HIV in Egypt: from Silent Emergence to Concentrated Epidemic - A Narrative Review of Past, Present and Future

ASIDE Internal Medicine
Introduction: Human immunodeficiency virus (HIV) continues to represent one of the most significant public health challenges, with Egypt facing a rapidly and silently growing epidemic masked by its low-prevalence classification.
Asem Mohsen, Mostafa Alfishawy
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Human Readers versus AI-Based Systems in ASPECTS Scoring for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis with Region-Specific Guidance

ASIDE Internal Medicine
Introduction: The Alberta Stroke Program Early CT Score (ASPECTS) is widely used to evaluate early ischemic changes and guide thrombectomy decisions in acute stroke patients.
Ahmed Y Azzam, Ibrahim Hadadi, Leen M. Al-Shahrani, Ummkulthum A. Shanqeeti, Noor A. Alqurqush, Mohammed A. Alsehli, Rudaynah S. Alali, Rahaf S. Tammar, Mahmoud M. Morsy, Muhammed Amir Essibayi   +9 more
doaj   +1 more source