Results 91 to 100 of about 8,905 (245)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Is De Dicto motivation manifestly a no-go?
Rivista Internazionale di Filosofia e PsicologiaThe aim of this paper is to challenge Michael Smith’s influential “fetishism charge” against motivational externalism – the view that moral judgments motivate only in the presence of a distinct conative state.
Irene Bosco
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Wittgenstein on Knowledge (1949-1951) [PDF]
, 2003 In this paper, I want to characterize Wittgenstein"s epistemology, namely his contextualism, presented in his notes published under the title On Certainty.
Bouchard, Yves
core
Reasons and Theories of Sensory Affect [PDF]
, 2018 Some sensory experiences are pleasant, some unpleasant. This is a truism. But understanding what makes these experiences pleasant and unpleasant is not an easy job. Various difficulties and puzzles arise as soon as we start theorizing.
Aydede, Murat, Fulkerson, Matthew
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
‘Putting apes (body and language) together again’, a review article of Savage-Rumbaugh, S., Taylor, T. J., and Shanker, S. G. Apes, Language, and the Human Mind (Oxford: 1999) and Clark, A. Being There: Putting Brain, Body, and World Together Again (MIT: 1997) [PDF]
, 2003 It is argued that the account of Savage-Rumbaugh’s ape language research in Savage-Rumbaugh, Shanker and Taylor (1998. Apes, Language and the Human Mind.
Cowley, Stephen, Spurrett, David
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Resultant moral luck and the scope of moral responsibility. [PDF]
Philos Stud, 2023 Rolffs M.
europepmc +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source