Phenomenal Conservatism, Reflection and Self-Defeat [PDF]
, 2016 Huemer defends phenomenal conservatism (PC) and also the further claim that belief in any rival theory is self-defeating (SD). Here I construct a dilemma for his position: either PC and SD are incompatible, or belief in PC is itself self-defeating.
Beillard, Julien
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Should We Swap Internal Foundations for Virtues?
Crítica, 2019 Internalist foundationalism was popular through much of the history of Western epistemology, but has been subjected to intense critical scrutiny in the last century.
Ram Neta
doaj +1 more source
‘Putting apes (body and language) together again’, a review article of Savage-Rumbaugh, S., Taylor, T. J., and Shanker, S. G. Apes, Language, and the Human Mind (Oxford: 1999) and Clark, A. Being There: Putting Brain, Body, and World Together Again (MIT: 1997) [PDF]
, 2003 It is argued that the account of Savage-Rumbaugh’s ape language research in Savage-Rumbaugh, Shanker and Taylor (1998. Apes, Language and the Human Mind.
Cowley, Stephen, Spurrett, David
core
Internal History versus External History [PDF]
, 2017 The aim of this paper is to generalize a pair of concepts that are widely used in the history of science, in art history and in historical linguistics – the concept of internal and external history – and to replace the often very ...
Aunger +51 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Minimalist Meaning, Internalist Interpretation
Biolinguistics, 2008 This article offers a conception of semantics, and of what makes the human language faculty distinctive, based on five theses: Meanings are instructions to build concepts; concatenation calls for conjunction of monadic concepts; grammatical relations ...
Paul M. Pietroski
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Resultant moral luck and the scope of moral responsibility. [PDF]
Philos Stud, 2023 Rolffs M.
europepmc +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source