Results 81 to 90 of about 8,905 (245)

Justification [PDF]

, 2018
In the most general sense, the term“justification” refers to the act of providing reasons for the validity, legitimacy, and defensibility of (1) an action, (2) a belief, and/or (3) a social arrangement.
Susen, S.
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Metaethics in context of engineering ethical and moral systems [PDF]

, 2016
It is not clear to what the projects of creating an artificial intelligence (AI) that does ethics, is moral, or makes moral judgments amounts. In this paper we discuss some of the extant metaethical theories and debates in moral philosophy by which such ...
Frank, Lily, Klincewicz, Michal
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Epistemic internalism [PDF]

, 2010
The internalism/externalism debate is of interest in epistemology since it addresses one of the most fundamental questions in the discipline: what is the basic nature of knowledge and epistemic justification?
Madison, Brent J C
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Problem indywiduacji i internalizacji działań (The Problem of Action Individuation and Internalization) [PDF]

Analiza i Egzystencja, 2010
One of the striking features of Davidson’s account of action individuation is the internalization of actions to the domain of bodily movements. I reconstruct Davidson’s arguments for that claim as applying mainly against naïve externalism (according to ...
Katarzyna Paprzycka
doaj  

RATIONALITY: NORMAL MENTAL FUNCTIONING OR PSYCHOLOGICAL COHERENCE?

Problemos, 2012
A version of the rationalist internalist argument, employing a pro tanto reading of the term “normative reason”, is often criticized due to its conception of rationality.
Ieva Vasilionytė
doaj   +1 more source

Immorality and Irrationality [PDF]

, 2019
Does immorality necessarily involve irrationality? The question is often taken to be among the deepest in moral philosophy. But apparently deep questions sometimes admit of deflationary answers.
Brunero J., Darwall S., Finlay S., Fogal D., Harman G., Kelly T., McDowell J., Rosenthal C., Scanlon T., Scanlon T., Schroeter F., Smith M., Smith M., Wallace R.J., Wedgwood R., Williamson T., Worsnip A., Worsnip A.   +17 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Hierarchy Theory of Evolution and the Extended Evolutionary Synthesis: Some Epistemic Bridges, Some Conceptual Rifts [PDF]

, 2018
Contemporary evolutionary biology comprises a plural landscape of multiple co-existent conceptual frameworks and strenuous voices that disagree on the nature and scope of evolutionary theory.
A Etxeberria, A Fuentes, A Parravicini, A Vianello, A Wagner, AC Love, Alejandro Fábregas-Tejeda, AV Badyaev, B Bocxlaer Van, BS Lieberman, BS Lieberman, D Noble, D Sepkoski, D Sloan-Wilson, DD Turner, DJ Depew, DJ Futuyma, DJ Nicholson, DL Hull, DM Walsh, DR Piperno, DT Campbell, E Danchin, E Jablonka, E Jablonka, E Jablonka, E Mayr, E Mayr, E Serrelli, E Szathmáry, EI Svensson, ES Vrba, ES Vrba, ES Vrba, F Suman, F Vergara-Silva, FJ Odling-Smee, FJ Odling-Smee, Francisco Vergara-Silva, GB Müller, GB Müller, GG Simpson, GJ Cooper, GP Wagner, GP Wagner, I Tëmkin, I Tëmkin, I Tëmkin, J Beatty, J Griesemer, J Griesemer, J Odling-Smee, J Odling-Smee, JJ Welch, JW Pepper, K Laland, K Laland, K Stotz, KN Laland, KN Laland, KN Laland, KN Laland, M Bertolaso, M Blute, M Lynch, M Martínez, M Nei, M Pavličev, M Pigliucci, M Pigliucci, MD Laubichler, MJ Denton, MW Kirschner, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, P Alberch, P Bateson, P Godfrey-Smith, PJ Bowler, R Amundson, R Amundson, R Riedl, R Sansom, RG Delisle, RG Winther, S Caianiello, S Okasha, S Okasha, S Oyama, S Sultan, SF Gilbert, SJ Gould, SJ Gould, T Ingold, T Ingold, T Pievani, T Pievani, T Pievani, T Pievani, TA Grantham, TS Kemp, TS Kemp, U Dieckmann, W Miller III, W Miller III, WB Provine, WD Allmon, WE Reif   +113 more
core   +1 more source