Results 71 to 80 of about 3,585 (189)
Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice
Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.ABSTRACT Anxiety disorders rank among the most prevalent mental health conditions worldwide, significantly affecting patients' lives. They are frequently comorbid with other psychiatric disorders, often exacerbating their severity. Current pharmacological treatments; selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines, remain limited in
Salma R. Abdennebi +4 more
wiley +1 more source
Developmental Requirement of Homeoprotein Otx2 for Specific Habenulo-Interpeduncular Subcircuits
, 2019 International audienceThe habenulo-interpeduncular system (HIPS) is now recognized as a critical circuit modulating aversion, reward, and social behavior. There is evidence that dysfunction of this circuit leads to psychiatric disorders.
Bethus, Ingrid +7 more
core +1 more source
Brain asymmetry is encoded at the level of axon terminal morphology
Neural Development, 2008 Background Functional lateralization is a conserved feature of the central nervous system (CNS). However, underlying left-right asymmetries within neural circuitry and the mechanisms by which they develop are poorly described.
Russell Claire +4 more
doaj +1 more source
The Brain of the African Wild Dog. VI. The Motor System
Journal of Comparative Neurology, Volume 533, Issue 7, July 2025.Neurofilament H‐immunostained coronal section through the rostral portion of the hypoglossal nucleus of the African wild dog brain. Note the presence of a distinct fascicle of protoplasmic commissural dendrites between the nuclei. This feature may be related to complex control of the tongue and vocalizations in this socially complex species.
Samson Chengetanai +6 more
wiley +1 more source
, 2014 Purpose: The habenulo-interpeduncular (HI) and mammillothalamic (MT) tracts are phylogenetically ancient. The clinical relevance of these tracts has recently received attention. In this work, we map the anatomy the developing HI and MT.
Jang, Hyung Suk +6 more
core +1 more source
Gpr149 is involved in energy homeostasis in the male mouse [PDF]
PeerJGPR149 is an orphan receptor about which little is known. Accordingly, in the present study, we mapped the tissue expression of Gpr149 in mice using three complementary approaches: quantitative PCR, in situ hybridization, and a newly generated Gpr149-Cre
Steven Wyler +5 more
doaj +2 more sources
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 45, Issue 2, June 2025.Recent advances challenge the traditional view of serotonin as a uniform neuromodulatory system, revealing the functional diversity of serotonin neurons in raphe nuclei, including the dorsal (DRN) and median raphe nuclei (MRN). This review highlights how distinct serotonergic subpopulations exert opposing effects on emotional regulation, necessitating ...
Yu Ohmura, Kazuki Nagayasu
wiley +1 more source
, 1992 The preceding companion study (Eckenrode et al., 1992) showed that cell suspension transplants of fetal habenula cells placed near the interpeduncular nucleus (IPN) following lesions of the fasciculus retroflexus (FR) restore the normal pattern of ...
TC Eckenrode, F Haun, M Murray
core +1 more source
Frontiers in Neuroscience, 2019 GPR139, a Gq-coupled receptor that is activated by the essential amino acids L-tryptophan and L-phenylalanine, is predominantly expressed in the brain and pituitary.
Lien Wang +7 more
doaj +1 more source