Results 51 to 60 of about 318,868 (184)

STZ-induced hyperglycemia differentially influences mitochondrial distribution and morphology in the habenulointerpeduncular circuit

Frontiers in Cellular Neuroscience
IntroductionDiabetes is a metabolic disorder of glucose homeostasis that is a significant risk factor for neurodegenerative diseases, such as Alzheimer’s disease, as well as mood disorders, which often precede neurodegenerative conditions.
Mohammad Jodeiri Farshbaf, Mohammad Jodeiri Farshbaf, Taelor A. Matos, Taelor A. Matos, Kristi Niblo, Kristi Niblo, Yacoub Alokam, Jessica L. Ables, Jessica L. Ables, Jessica L. Ables   +9 more
doaj   +1 more source

Organization of multisynaptic inputs to the dorsal and ventral dentate gyrus: retrograde trans-synaptic tracing with rabies virus vector in the rat.

PLoS ONE, 2013
Behavioral, anatomical, and gene expression studies have shown functional dissociations between the dorsal and ventral hippocampus with regard to their involvement in spatial cognition, emotion, and stress. In this study we examined the difference of the
Shinya Ohara, Sho Sato, Ken-Ichiro Tsutsui, Menno P Witter, Toshio Iijima   +4 more
doaj   +1 more source

Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior

Scientific Reports, 2021
Calcium-dependent secretion activator 2 (CAPS2) regulates the trafficking and exocytosis of neuropeptide-containing dense-core vesicles (DCVs). CAPS2 is prominently expressed in the medial habenula (MHb), which is related to depressive behavior; however,
Hyeijung Yoo, Soo Hyun Yang, Jin Yong Kim, Esther Yang, Hyung Sun Park, Se Jeong Lee, Im Joo Rhyu, Gustavo Turecki, Hyun Woo Lee, Hyun Kim   +9 more
doaj   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Distribution of catecholamine fibers in the cochlear nucleus of horseshoe bats and mustache bats [PDF]

, 1988
The glyoxylic-acid-induced fluorescence technique was applied to demonstrate patterns of catecholaminergic innervation within the auditory brainstem of echolocating bats and the house mouse.
Kössl, M., Vater, M., Schweizer, Hermann   +2 more
core   +1 more source

Evolutionary plasticity of habenular asymmetry with a conserved efferent connectivity pattern. [PDF]

PLoS ONE, 2012
The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain.
Aldo Villalón, Mauricio Sepúlveda, Néstor Guerrero, Margarita M Meynard, Karina Palma, Miguel L Concha   +5 more
doaj   +1 more source

Afferent and efferent connections of the interpeduncular nucleus, with special reference to the circuits linking the habenula, interpeduncular nucleus, and raphe nuclei.

, 2019
A habênula é uma estrutura epitalâmica diferenciada em dois complexos nucleares, a habênula medial (MHb) e a habênula lateral (LHb). Recentemente, a MHb junto com seu alvo principal, o núcleo interpeduncular (IP), foram identificados como estruturas ...
Bueno, Débora Nunes Martins
core   +1 more source

Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal [PDF]

, 2016
This article has been corrected. See Nat Commun. 2015 July 02; 6: 7625.Increased anxiety is a prominent withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear.
Tapper, Andrew R., Pang, Xueyan, Gao, Guangping, Martin, Gilles E, Su, Qin, Zhao-Shea, Rubing, Liu, Liwang, Vallaster, Markus, Rando, Oliver J., DeGroot, Steven R., George, Olivier, Gardner, Paul D.   +11 more
core   +1 more source

The Role of Interpeduncular Nucleus Somatostatin Neurons in Alcohol Drinking in Mice [PDF]

Binge drinking (BD) induces behavioral disturbances that accelerate the progression of alcohol use disorders (AUD). Despite the high prevalence of BD and AUD, the neural circuits that regulate BD behavior are not yet fully understood. In this project, we
Kolb, Miranda
core   +7 more sources

Transcriptional Response to Chronic Long‐Access Fentanyl Self‐Administration in Rat Habenula and Amygdala

Addiction Biology, Volume 31, Issue 7, July 2026.
Chronic intravenous long‐access fentanyl self‐administration in rats produced transcriptional remodeling in the habenula and amygdala. Bulk RNA‐sequencing identified 453 habenula and 3,041 amygdala differentially expressed genes, revealing upregulation of synaptic process and ionic conductance genes in habenula, upregulation of metabolic and vesicular ...
Robin Magnard, Daianna Gonzalez‐Padilla, Ege A. Yalcinbas, Emma Chaloux‐Pinette, Nicholas J. Eagles, Michael S. Totty, Patricia H. Janak, Leonardo Collado‐Torres, Kristen R. Maynard   +8 more
wiley   +1 more source