Integrated miRNA-/mRNA-Seq of the Habenulo-Interpeduncular Circuit During Acute Nicotine Withdrawal
Scientific Reports, 2020 Tobacco use is the leading preventable cause of mortality in the world. The limited number of smoking cessation aids currently available are minimally effective, highlighting the need for novel therapeutic interventions.
Alison P. Casserly +7 more
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GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals
eLife, 2021 The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel tetramerization
Pradeep Bhandari +12 more
doaj +1 more source
Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms. [PDF]
Curr Biol, 2013 SummaryBackgroundChronic exposure to nicotine elicits physical dependence in smokers, yet the mechanism and neuroanatomical bases for withdrawal symptoms are unclear. As in humans, rodents undergo physical withdrawal symptoms after cessation from chronic
Zhao-Shea R +4 more
europepmc +2 more sources
Frontiers in Neuroanatomy, 2022 This study reports for the first time the distribution and morphological characterization of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d; a reliable marker of nitric oxide synthase activity) positive elements in the central nervous ...
Manuel A. Pombal +3 more
doaj +1 more source
Mapping of neurokinin-like immunoreactivity in the human brainstem
BMC Neuroscience, 2003 Background Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.
Narvaez Jose +10 more
doaj +1 more source
SEXUAL DIMORPHISM OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) IMMUNOREACTIVITY IN THE RAT INTERPEDUNCULAR NUCLEUS [PDF]
, 2001 The intensity of immunostaining for the glial fibrillary acidic protein (GFAP) is outstandingly high in the interpeduncular nucleus. This nucleus was compared in males and females for its GFAP immunoreaction.
Szalay, F. +3 more
core +1 more source
Griseum centrale, a homologue of the periaqueductal gray in the lamprey
IBRO Reports, 2017 Fear, a response to threatening stimuli and important for survival, is a behavior found throughout the animal kingdom. One critical structure involved in the expression of fear-related behavior is the periaqueductal gray (PAG) in mammals, and in the ...
Ian Olson +3 more
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Understanding the habenula: A major node in circuits regulating emotion and motivation
Pharmacological Research, 2023 Over the last decade, the understanding of the habenula has rapidly advanced from being an understudied brain area with the Latin name ‘habena” meaning “little rein”, to being considered a “major rein” in the control of key monoaminergic brain centers ...
Jessica L. Ables +2 more
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The interpeduncular nucleus regulates nicotineʼs effects on free-field activity
, 1995 PARTIAL lesions were made with kainic acid in the interpeduncular nucleus of the ventral midbrain of the rat. Compared with sham-operated controls, lesions significantly (p < 0.25) blunted the early (< 60min) free- field locomotor hypoactivity caused by ...
Gollapudi, Lakshmi, Hentall, Ian
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Cholinergic and non-cholinergic forebrain projections to the interpeduncular nucleus
, 1985 A combined fluorescent retrograde tracing and acetylcholinesterase (AChE) histochemical technique was used for the study of some forebrain projections to the interpeduncular nucleus (IPN).
Albanese, Alberto
core +1 more source